Association between functional polymorphisms in the flanking region of miR-143/145 and risk of papillary thyroid carcinoma

Wang, Yichao; Zhou, Shengliang; Zhao, Wanjun; Li, Zhihui; Zhu, Jingqiang; Tao, Wei; Song, Haolan

doi:10.1097/md.0000000000023560

Cited by 3 publications

(6 citation statements)

References 28 publications

(16 reference statements)

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“…The TT/CT genotypes of rs353292 were found to be associated with a higher risk of chronic kidney disease and colorectal cancer (15,16). However, there was no significant correlation between the rs353292 polymorphism and susceptibility to papillary thyroid carcinoma and conotruncal heart defects (25,26). In the present study, our results also demonstrated that the genotype frequencies of rs353292 were not significantly different between T2DM patients and controls.…”

Section: Discussionsupporting

confidence: 51%

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Kong

Duan²,

Wang³

et al. 2022

Front. Endocrinol.

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ObjectiveTo explore the association between two polymorphisms of microRNA-143 (miR-143) and the risk of type 2 diabetes mellitus (T2DM) in the northern Chinese Han population.Study DesignThis case–control study involved 326 patients with T2DM and 342 healthy controls. Two genetic variants (rs4705342 and rs353292) of miR-143 were genotyped by the polymerase chain reaction/ligase detection reaction (PCR-LDR) method. The levels of miR-143 in the serum from 52 T2DM patients and 55 healthy subjects were investigated by quantitative real-time PCR (qRT–PCR).ResultsThe CC genotype frequency of rs4705342 was significantly higher in the T2DM patients than in the healthy controls (P = 0.012). After adjusting for sex, age, and body mass index, the rs4705342 CC genotype was also related to a significantly increased risk of T2DM compared with the TT genotype (adjusted OR: 1.87; 95% CI = 1.09-3.19; P = 0.022). Stratified analyses demonstrated that T2DM patients with the rs4705342 CC genotype had significantly higher levels of low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), and glycated haemoglobin (HbA1C) than those carrying the rs4705342 TT genotype. The qRT–PCR results showed that the expression levels of miR-143 were significantly higher in the serum of cases than in the serum of controls (P < 0.001). Furthermore, the levels of miR-143 were significantly higher in the serum of T2DM patients carrying the rs4705342 CC genotype than in those carrying the TC and TT genotypes of rs4705342 (P = 0.005 and 0.003, respectively).ConclusionThe CC genotype of rs4705342 might be a risk factor for developing T2DM by increasing the expression of miRNA-143 in the northern Chinese Han population.

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Section: Discussionsupporting

confidence: 51%

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Kong

Duan²,

Wang³

et al. 2022

Front. Endocrinol.

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“…Systematic search; duplicate removal; and screening of titles, abstracts, and full text yielded eight eligible articles [ 41 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. The expression of miR-145 was significantly reduced in thyroid cancer compared with normal cells [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…Overexpression of miR-145 may reverse the EMT phenotype of thyroid cancer cells; relative levels of miR-145 in thyroid cancer tissues were significantly lower than in the corresponding normal tissues [ 46 ]. Moreover, Wang et al, testing genetic variants flanking the miR-145 gene, found significant association between rs4705342*T single nucleotide polymorphism and a higher risk of papillary thyroid carcinoma [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence

Toraih

Fawzy

Niu

et al. 2022

Cancers

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Papillary thyroid carcinomas (PTCs) account for most endocrine tumors; however, screening and diagnosing the recurrence of PTC remains a clinical challenge. Using microRNA sequencing (miR-seq) to explore miRNA expression profiles in PTC tissues and adjacent normal tissues, we aimed to determine which miRNAs may be associated with PTC recurrence and metastasis. Public databases such as TCGA and GEO were utilized for data sourcing and external validation, respectively, and miR-seq results were validated using quantitative real-time PCR (qRT-PCR). We found miR-145 to be significantly downregulated in tumor tissues and blood. Deregulation was significantly related to clinicopathological features of PTC patients including tumor size, lymph node metastasis, TNM stage, and recurrence. In silico data analysis showed that miR-145 can negatively regulate multiple genes in the TC signaling pathway and was associated with cell apoptosis, proliferation, stem cell differentiation, angiogenesis, and metastasis. Taken together, the current study suggests that miR-145 may be a biomarker for PTC recurrence. Further mechanistic studies are required to uncover its cellular roles in this regard.

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“…The association between rs4705342 and cancer risk has been examined extensively, but the results were controversial. The C allele of rs4705342 was found to play a protective role against the occurrence of papillary thyroid carcinoma (18). However, Kotarac et al (19) reported that the rs4705342 C variant was associated with an increased risk of prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…To date, several polymorphisms have been identified in the miR-143/145 cluster. Among these polymorphisms, two widely studied polymorphisms (rs4705342 and rs353292) have been reported to be correlated with the risk of tumor development and cancer progression (17)(18)(19)(20). In this study, we evaluated the effects of the two genetic variants on the risk of EOC and the prognosis of EOC patients from North China.…”

Section: Introductionmentioning

confidence: 99%

The polymorphism rs4705342 in the promoter of miR-143/145 is related to the risk of epithelial ovarian cancer and patient prognosis

et al. 2023

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ObjectiveTo evaluate the effects of two genetic variants in the promoter of the miR-143/145 cluster on the risk of epithelial ovarian cancer (EOC) and the prognosis of EOC patients.Study designGenotypes were determined by the polymerase chain reaction and ligase detection reaction method in 563 EOC patients and 576 healthy women. The expression of miR-143 and miR-145 were detected by quantitative real-time polymerase chain reaction (qRT–PCR) in fifty-two EOC tissues.ResultsThe rs4705342 CC genotype frequencies in EOC patients were higher than those in the controls (P = 0.014). Furthermore, the CC genotype of rs4705342 was associated with an advanced FIGO stage of EOC patients (P = 0.046). Patients with the rs4705342 CC genotype had shorter progression-free survival (PFS) and overall survival (OS) times than those carrying the TT genotype in multivariable analysis adjusting for clinical variables (HR = 1.30, 95% CI = 1.04-1.62, P = 0.020; HR = 1.33, 95% CI = 1.05-1.70, P = 0.020). In addition, the miR-145 levels were lower in EOC tissues with the rs4705342 CC genotype than in those with the TT genotype (P = 0.005).ConclusionThe CC genotype of rs4705342 was related to an increased risk of EOC and poor prognosis of EOC patients, and rs4705342 may serve as a molecular marker for predicting the development of EOC and the clinical outcome of EOC patients.

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Association between functional polymorphisms in the flanking region of miR-143/145 and risk of papillary thyroid carcinoma

Cited by 3 publications

References 28 publications

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence

The polymorphism rs4705342 in the promoter of miR-143/145 is related to the risk of epithelial ovarian cancer and patient prognosis

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