Association between FSHR and ESR1 gene variants and ovarian response to gonadotropin in Egyptian women undergoing ICSI treatment

Ismael, Ahmed Haki; Abdelateef, Sara; Abdel-Lah, Moustafa Abdel-Khalik; Amor, Houda; Hammadeh, Mohamad Eid

doi:10.1016/j.repbio.2021.100499

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…FSHR :c.919G>A and FSHR :c.2039G>A were previously associated with variability in serum FSH levels and reproductive outcomes in different populations ( 11 – 13 , 15 , 30 – 34 ). These SNVs are located in the coding region of the FSHR gene and have been well characterized ( 13 ).…”

Section: Discussionmentioning

confidence: 86%

Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis

et al. 2021

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BackgroundSingle nucleotide variants (SNVs) FSHB:c.-211G>T, FSHR:c.919G>A, and FSHR:c.2039G>A were reported to be associated with the variability in FSH and LH levels, and in vitro fertilization (IVF) outcomes. In this study, we aimed to evaluate the effects of FSHB:c.-211G>T, FSHR:c.919G>A, and FSHR:c.2039G>A variants, alone and combined, on the hormonal profile and reproduction outcomes of women with endometriosis.MethodsA cross-sectional study was performed comprising 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables were compared according to the genotypes of each variant and genetic models, and the combined effects of the SNVs were evaluated using the multifactorial dimensionality reduction method.ResultsFSHB:c.-211G>T affected LH levels in women with overall endometriosis and minimal/mild disease. FSHR:c.919G>A affected FSH levels in women with overall endometriosis and the number of oocytes retrieved in those with moderate/severe endometriosis. Moreover, the FSHR:c.2039G>A affected FSH levels in women with overall endometriosis, LH levels and total amount of rFSH in those with minimal/mild disease, and number of follicles and number of oocytes retrieved in those with moderate/severe endometriosis. No effect on hormone profile or reproductive outcomes was observed when the genotypes were combined.ConclusionsVariants of the FSHB and FSHR genes separately interfered with the hormonal profiles and IVF outcomes of women with endometriosis.

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Section: Discussionmentioning

confidence: 86%

Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis

et al. 2021

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“…Islam A. and Radia B . showed that SNPs of FSH receptor impact on number of graafian follicles and this effect on the response to ovarian stimulation in infertile women (23,12).…”

Section: Discussionmentioning

confidence: 99%

Role of FSHR gene (rs6165) polymorphism in ovarian stimulation by exogenous FSH of Iraqi infertile women

Hussein

Abdulwahab

Oda

2022

ijhs

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Background: Exogenous FSH has been dispensed to induce follicular growth both when monofollicular development was required and when multifollicular growth was desired to generate multiple mature oocytes. Methods: 210 infertile women and 50 healthy women aged less than 34 years were recruited in present study, the infertile women were separated to three groups based on treatment response (poor ,moderate and high ) responder groups. Results: The outcomes indicated that poor responder group displayed higher levels of FSH and LH also lower levels of AMH,E2,AFC. Conclusion: Polymorphism of FSHR gene(rs6165) was linked to poor response to FSH treatment of Iraqi infertile women.

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Association of FSHR gene polymorphisms with poor ovarian response in patients undergoing IVF: A systematic review and meta-analysis

Hu,

Jing,

et al. 2024

Gene

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Association between FSHR and ESR1 gene variants and ovarian response to gonadotropin in Egyptian women undergoing ICSI treatment

Cited by 5 publications

References 30 publications

Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis

Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis

Role of FSHR gene (rs6165) polymorphism in ovarian stimulation by exogenous FSH of Iraqi infertile women

Association of FSHR gene polymorphisms with poor ovarian response in patients undergoing IVF: A systematic review and meta-analysis

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