Association between fruit and vegetable allergies and pollen-food allergy syndrome in Japanese children: a multicenter cross-sectional case series

Abstract

Background: Recently, the prevalence of food allergies during childhood is increasing, with fruits being common allergens. However, data on allergens that cause fruit and vegetable allergies and pollen-food allergy syndrome (PFAS) in childhood are relatively few. This study aimed to examine the allergens in fruit and vegetable allergies in pediatric patients and to determine the association between fruit and vegetable allergies and PFAS.Objective: This study aimed to examine the current status of fruit and vegetable allergies in Japanese children. Methods: This was a multicenter case series observational study. The participants included children aged <15 years who developed allergic symptoms after eating fruits and vegetables and subsequently received treatment in the Pediatric Department of 6 hospitals in the Osaka Prefecture in Japan during the study period from August 2016 to July 2017. Participants' information was obtained using a questionnaire, and data were obtained by performing several types of allergy tests using blood samples. Results: A total of 97 children (median age, 9 years; 56 males) were included in the study. Apple was the most common allergen, followed by peach, kiwi, cantaloupe, and watermelon. A total of 74 participants (76%) exhibited allergic symptoms due to PFAS; moreover, pathogenesis-related protein-10 (PR-10) was the most common allergen superfamily. On the contrary, in the group where neither PR-10 nor profilin was sensitized, kiwi and banana were the most common allergens, and the age of onset was lower than that in the PFAS group. Specific antibody titer was significantly associated with Birch for Bet v1 and latex for Bet v2 (r = 0.99 and r = 0.89). Conclusion:When we examine patients with fruit and vegetable allergies, we should first consider PFAS even in childhood specifically for children greater than 4 years old.

In vivo Induction of Functional Inhibitory IgG Antibodies by a Hypoallergenic Bet v 1 Variant

“…All procedures and protocols were approved by the National Animal Experiment Board of Finland in accordance with the EU Directive 2010/63/EU on the protection of animals used for scientific purposes under the license numbers ESAVI/7217/04. 10 (29). Plates were measured at a wavelength of 450 nm using an ELISA Reader Infinite 200 PRO (Tecan, Switzerland).…”

“…This clinical manifestation is described as the pollen food allergy syndrome (PFAS) ( 5 ). Apples and hazelnuts belong to the most common allergenic sources amongst plant foods eliciting birch pollen-associated PFAS symptoms ( 8 , 10 , 11 ). Here, the culprit allergens responsible for triggering PFAS are the Bet v 1-homologous pathogenesis-related protein-10 (PR-10) class proteins Mal d 1 (apple, Malus domestica ) and Cor a 1 (hazelnut, Corylus avellana ).…”

Alergeny ziół kulinarnych i warzyw ważne dla pielęgniarki lub dietetyczki

“…Kontakt alergenu z przeciwciałem E (IgE) powoduje zazwyczaj reakcje szybkie, do około 2 godzin po spoz yciu, niekiedy gwałtowne (anafilaktyczne). Mo wimy wo wczas o reakcji humoralnej typu I wg Gella i Coombsa [12]. Przymiotnik humoralne podkres la fakt, z e przeciwciała E są zawarte w surowicy, choc mogą wiązac się z komo rkami poprzez odpowiednie receptory (chwytniki).…”

“…Trzecia nauka z oznaczenia IgE dla molekuły Bet v 1 zamiast oddzielnie dla mieszanin komponent jabłka, selera, marchwi, bazylii, brzozy czy leszczyny to informacja o włas ciwos ciach kulinarnych cząsteczki Bet v1 i jej odpowiedniko w (homologo w) w pokarmach. Oto z białka z grupy PR-10, takie jak jabłkowe Mal d 1, selerowe Api g 1, marchwiowe Dau c 1, pietruszkowe Pet c 1 i bazyliowe Oci b są termolabilne [12]. Oznacza to, z e poddane ogrzewaniu tracą włas ciwos ci wywoływania objawo w uczulenia.…”

The 10th Anniversary of Asia Pacific Allergy

“…This issue contains interesting articles on banana-induced anaphylaxis from Thailand [6], and the association between fruit and vegetable allergies and pollen-food allergy in Japanese children [7]. Most patients have oral allergy syndrome.…”