Association between free thyroid hormones values and the lipid profile in middle-aged women with chronic symptoms

Guarnizo-Poma, Mirella; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Lázaro-Alcántara, Herbert; Urrunaga-Pastor, Diego; Benítes-Zapata, Vicente A.

doi:10.1016/j.dsx.2018.03.023

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…As observed previously, thyroid hormones THs are capable to regulate the expression of LDLR, that results in changed cellular absorption and catabolism of LDL. T3 reduces the plasma concentration of cholesterol, via promoting its hepatic intake and conversion to bile acids and via promoting fecal bile acid secretion (17).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the lipid profile level in patients with hypothyroidism

A. Nassif,

H. Mahmood

2024

J. K. Chem. Sci.

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The thyroid gland is considered one of the most important endocrine glands in the human body. It controls blood pressure, heart rate, temperature, weight, and other vital functions.The aim of this study is to evaluate the level of lipid in patients with hypothyroidism. The study was included 60 female patients with hypothyroidism and 40 healthy women, who were considered as control group, in the age group range from 22 to 44 years.The results of this study showed that subjects with hypothyroidism had significant increase in the level of lipids, as the levels of total cholesterol, triglycerides, and low-density lipoprotein were (248.0±59.3, 226.7±52.5, and 145.0±32.6) mg/dL, respectively. , compared with the control group, (189.1 ±30.5, 189.6 ±36.1, 95.8 ±22.9) mg/dL, respectively. While the level of high-density lipoprotein cholesterol and very low-density lipoprotein, there were high differences, as it reached (50.5 ± 11.6, 42.8 ± 12.1) mg /dL compared to healthy subjects, which amounted to (55.1 ± 13.7, 38.2 ± 11.2), mg/dL. We conclude from this study that hypothyroidism leads to an increase in the level of fats, due to a decreasing in metabolic processes, which is also the cause of hyperlipidemia.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the lipid profile level in patients with hypothyroidism

A. Nassif,

H. Mahmood

2024

J. K. Chem. Sci.

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“…In addition to promoting tissue differentiation, maintaining the excitability of the nervous system and promoting protein synthesis (18), thyroid hormones can also affect sugar and lipid metabolism (19), and it participates in the development of various diseases such as diabetes, coronary heart disease (20). Several reports (21)(22)(23) have explored the relationship between thyroid hormones and glucose and lipid metabolism in T2DM patients, and have provide some theoretical basis for the treatment and T2DM. it's been found in T2DM female patients with normal thyroid function, TSH is positively correlated with TC and LDL-C, but it has no significant correlation with TG and HDL-C, but in male patients, TSH and TC, TG, LDL-C and HDL-C have no obvious correlation (24).…”

Section: Discussionmentioning

confidence: 99%

The thyroid hormone levels and glucose and lipid metabolism in children with type 1 diabetes: a correlation analysis

Yuan¹,

Sun²,

Liu³

et al. 2021

Transl Pediatr

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Background: Type 1 diabetes mellitus (T1DM) is common in clinical setting, the relationship between thyroid hormone levels and glucose and lipid metabolism in patients with T1DM remains unclear. We attempted to analyze the correlation of thyroid hormone levels and blood glucose and lipid metabolism in children with normal thyroid function.Methods: Children with T1DM were selected, and 85 healthy children who underwent physical examinations in our hospital as control group. The characteristics and laboratory testing results were compared, the correlation of thyroid hormone levels with blood glucose and blood lipids was analyzed by Pearson correlation analysis. Results: A total of 167 participants were included. the low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), fasting blood glucose (FBG), and glycated hemoglobin (HbAlc) in T1DM patients were higher than those in healthy controls, while the high-density lipoprotein-cholesterol (HDL-C), thyroid stimulating hormone (TSH) and free triiodothyronine (FT3) in T1DM patients were lower than that of healthy children (all P<0.05). TSH was positively correlated with LDL-C (r=0.169, P=0.032), TC (r=0.182, P=0.017) and TG (r=0.197, P=0.008), negatively correlated with FBG (r=−0.196, P=0.023) and HbAlc (r=−0.328, P=0.002). FT3 was negatively correlated with TG (r=−0.182, P=0.011), FBG (r=−0.184, P=0.009)and HbAlc (r=−0.223, P=0.005). TG in the high TSH group and the middle TSH group is higher than that of low TSH group. However, FBG and HbAlc were lower than those in the low TSH group (all P<0.05).Compared with the low FT3 group, the TG, FBG and HbAlc decreased in the high and middle FT3 group (all P<0.05). Conclusions:The serum TSH are closely associated with FT3 and glycolipid metabolism in children with T1DM, which may be the useful indicators to assess the severity of T1DM in clinical settings to provide insights into the management of T1DM.

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“…Hyperthyroidism, like any other hormonal disturbances, if not the most, gives rise to disturbing physiological relevant parameters in both extremities [2,3] that predicted specifying the disease treatment as a complicated task. Given that hypothyroidism results in dyslipidemia [4] oxidative stress [1], and in more severity, to mental stress [5], insulin impairment [6] that uncover the OPEN ACCESS ORIGINAL RESEARCH published: 23 June 2022 Doi: https://doi:10.26505/DJM.22026271117 importance of the question; which laboratory parameters should be taken into consideration targeted to modulate the disease progression and development?. Recently, data analysis and applied distinctive statistical concepts in medical researches highlighted the dominant influence of some variables to have the key impact on the progress and development of diseases [7].…”

Section: Introductionmentioning

confidence: 99%

Association of Thyroid Hormones with Oxidative Stress Markers in Patient with Hyperthyroidism

Ahmed¹,

Maulood²,

Sabah³

et al. 2022

DJM

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Background: Biomarkers for diagnosing the occurrence and development of hyperthyroidism constitute a major worldwide clinical scrutiny. Evidence is continuing in an investigation about the most relevant biomarkers in developing the disease.Objective: To discover and correlate the most dependent biomarkers in developing hyperthyroidism in both genders.Patients and Methods: In the present study, two groups were included, the first group: forty males and females with chronic hyperthyroidism were enrolled. Serum levels of thyroid hormones, lipid profile, oxidative stress marker, blood glucose, and renal function markers were measured and compared with euthyroid subjects. Results: The present study revealed that referral biomarkers were varied between genders with a remarkable association of hyperthyroidism with serum cholesterol, triglycerides, and low-density lipoproteins in females, while nitrites and creatinine and MDA were significantly correlated in male patients. Conclusion: In this study, we found that indicating biomarkers for hyperthyroidism could be differentially changed in different genders that help in understanding the progression and development of the disease. Keywords: Hyperthyroidism, oxidative stress, malondialdehyde, creatinine, nitrite.

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Association between free thyroid hormones values and the lipid profile in middle-aged women with chronic symptoms

Abstract: We found an inverse association between the FT3 and LDL-c values in women with chronic gynaecological symptoms.

Cited by 3 publications

References 40 publications

Evaluation of the lipid profile level in patients with hypothyroidism

Evaluation of the lipid profile level in patients with hypothyroidism

The thyroid hormone levels and glucose and lipid metabolism in children with type 1 diabetes: a correlation analysis

Association of Thyroid Hormones with Oxidative Stress Markers in Patient with Hyperthyroidism

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