Association between frailty and depression: A bidirectional Mendelian randomization study

Deng, Ming-Gang; Liu, Fang; Liang, Yuehui; Wang, Kai; Nie, Jia-Qi; Liu, Jiewei

doi:10.1126/sciadv.adi3902

Cited by 44 publications

(13 citation statements)

References 52 publications

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“…Speed et al have shown that BMI is a causal risk factor for depression, but found no significant evidence that depression causes increased BMI [ 31 ]. These findings are consistent with other studies reporting that higher BMI causally increases the risk of depression, but that the inverse relation does not hold [ 32 , 33 ]. Obesity triggers dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, causing excessive cortisol production.…”

Section: Discussionsupporting

confidence: 92%

Dietary Factors and the Risk of Depression among Women with Polycystic Ovary Syndrome

Łagowska,

Bajerska,

Pieczyńska-Zając

2024

Nutrients

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This study aimed to assess the association between dietary factors and depression in a group of polycystic ovary syndrome (PCOS) women and to evaluate potential interactions and the mediating role of BMI in this relationship. One hundred and sixteen women with PCOS were asked to complete the Dietary Habits and Nutrition Beliefs Questionnaire and the manual for developing of nutritional data (KomPAN questionnaire) and the Beck Depression Inventory. The population was divided into two groups: (1) not at risk of depression (ND), n = 61, and (2) at risk of depression (RD), n = 55. Significantly higher BMI values were observed in the RD group than in the ND group. In the RD group, the intake of vegetables and legumes was lower than in the LD group, but the consumption of sweet beverages and energy drinks was higher. Consumption of vegetables and legumes at least twice per day is known to be associated with a 62% lower probability of the risk of depression in PCOS women. Furthermore, women with overweight and obesity have a 5.82 times greater chance of depression than women with normal body weight. Our findings show that there is a significant association between certain dietary factors, BMI, and symptoms of depression in PCOS women.

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Section: Discussionsupporting

confidence: 92%

Dietary Factors and the Risk of Depression among Women with Polycystic Ovary Syndrome

Łagowska,

Bajerska,

Pieczyńska-Zając

2024

Nutrients

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“…Furthermore, the Steiger directionality test validates the effectiveness of the vast majority of forward causality. Because the methodology of MR is inherently less susceptible to the spurious reverse causality, bidirectional MR can indeed suggest that two phenotypes drive each other, and this situation does not affect the validity of forward causality 64 . Second, there is mild horizontal pleiotropy in the MR analysis results for SHBG and HDL-C (p = 0.02), which could potentially violate assumption II and III, leading to inaccurate causal estimates 40 .…”

Section: Discussionmentioning

confidence: 99%

Blood lipid levels mediating the effects of sex hormone-binding globulin on coronary heart disease: Mendelian randomization and mediation analysis

Yang,

Zhou,

Liu

et al. 2024

Sci Rep

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Observational studies indicate that serum sex hormone-binding globulin (SHBG) levels are inversely correlated with blood lipid levels and coronary heart disease (CHD) risk. Given that dyslipidemia is an established risk factor for CHD, we aim to employ Mendelian randomization (MR) in conjunction with mediation analysis to confirm the mediating role of blood lipid levels in the association between SHBG and CHD. First, we assessed the causality between serum SHBG levels and five cardiovascular diseases using univariable MR. The results revealed causality between SHBG levels and reduced risk of CHD, myocardial infarction, as well as hypertension. Specifically, the most significant reduction was observed in CHD risk, with an odds ratio of 0.73 (95% CI 0.63–0.86) for each one-standard-deviation increase in SHBG. The summary-level data of serum SHBG levels and CHD are derived from a sex-specific genome-wide association study (GWAS) conducted by UK Biobank (sample size = 368,929) and a large-scale GWAS meta-analysis (60,801 cases and 123,504 controls), respectively. Subsequently, we further investigated the mediating role of blood lipid level in the association between SHBG and CHD. Mediation analysis clarified the mediation proportions for four mediators: high cholesterol (48%), very low-density lipoprotein cholesterol (25.1%), low-density lipoprotein cholesterol (18.5%), and triglycerides (44.3%). Summary-level data for each mediator were sourced from the UK Biobank and publicly available GWAS. The above results confirm negative causality between serum SHBG levels and the risk of CHD, myocardial infarction, and hypertension, with the causal effect on reducing CHD risk largely mediated by the improvement of blood lipid profiles.

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“…Recent studies suggest a bidirectional causal relationship between frailty and depression from a genetic perspective (Deng et al, 2023).…”

Section: Backg Rou N Dmentioning

confidence: 99%

Frailty and social isolation before and during the coronavirus disease 2019 pandemic among older adults: A path analysis

Su,

Hamatani,

Yuki

et al. 2023

Journal of Advanced Nursing

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AimTo explore the prevalence of social isolation among Japanese community‐dwelling older adults before and during the COVID‐19 pandemic as well as determine how family and friend connections before and during the pandemic affected frail older adults during the pandemic.DesignA cross‐sectional study.MethodsA total of 852 community‐dwelling older adults in Hokkaido and Tokyo, Japan were surveyed conducted between April and November 2021 using convenience sampling. The Lubben social network scale‐6, frailty screening index, and geriatric depression scale were used to assess social isolation, frailty and depression, respectively. A path analysis was conducted to evaluate the effect of social isolation on frailty.ResultsParticipants had a mean age of 76.8 ± 6.6 years. Overall, 46% and 59% of participants were socially isolated before and during the COVID‐19 pandemic, respectively. Frailty was found in 19% of participants during the pandemic. Friends and family connectedness before the pandemic had no direct relationship with frailty; only friend connectedness affected frailty indirectly via depression. Family connectedness during the pandemic had a significant, negative and direct relationship with frailty.ConclusionThe findings show that connectedness with family and friends is critical for older people's physical and mental health.ImpactNurses in the community should consider these findings to reduce mental health problems and physical decline among older adults. It is important to identify older adults who are socially isolated from their families or friends and provide resources to help them build relationships within their communities.Patient or Public ContributionCommunity centre staff and community volunteers assisted in data collection. The public was not involved in data analysis, interpretation or manuscript preparation.

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Association between frailty and depression: A bidirectional Mendelian randomization study

Cited by 44 publications

References 52 publications

Dietary Factors and the Risk of Depression among Women with Polycystic Ovary Syndrome

Dietary Factors and the Risk of Depression among Women with Polycystic Ovary Syndrome

Blood lipid levels mediating the effects of sex hormone-binding globulin on coronary heart disease: Mendelian randomization and mediation analysis

Frailty and social isolation before and during the coronavirus disease 2019 pandemic among older adults: A path analysis

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