Association between Fractional Exhaled Nitric Oxide and Asthma Control

Prottasan, P.; Maneechotesuwan, Kittipong; Vichyanond, Pakit; Jirapongsananuruk, Orathai; Pacharn, Punchama; Visitsunthorn, Nualanong

doi:10.1016/j.jaci.2010.12.050

Cited by 1 publication

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“…First, it has been demonstrated that about 30% of patients with CRSwNP show elevated FeNO comparable with asthmatics, but cannot be diagnosed as asthma [ 13 ], and thus may minimize the difference in FeNO between CRSwNP patients with and without asthma. Second, in the current study the levels of FeNO may be decreased by more applications of inhaled corticosteroids in patients with CRSwNP and comorbid asthma [ 44 ]. As the level of FeNO has been shown to be modestly associated with level of blood eosinophils [ 45 ], blood eosinophil count as an independent risk factor may to some degree also represent the role of FeNO in predicting the risk of comorbid asthma in CRSwNP patients.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with comorbid asthma in patients with chronic rhinosinusitis with nasal polyps: a cross-sectional study

Wang

Shen

et al. 2022

BMC Pulm Med

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Background Although 20–60% of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have asthma, the risk factors associated with comorbid asthma are not clear. The aim of the study was to investigate the factors associated with asthma, and develop a practical scoring system to screen asthma comorbidity in CRSwNP patients. Methods This report describes a cross-sectional study with consecutive CRSwNP patients. Two cohorts of CRSwNP patients named “modelling” group and “validation” group were investigated respectively. Logistic regression analysis was performed based on demographic and clinical data collected from patients in the modelling group to determine the risk factors associated with asthma, and establish a scoring system for screening comorbid asthma. Receiver operating characteristic curve was constructed to evaluate the screening system; the optimal cut-off point was established by means of the Yoden Index. The consistency between the diagnosis of asthma by the Global Initiative for Asthma (GINA) criteria and by the screening system was assessed by Kappa value in the validation group. Results Totally 150 patients in modelling group and 78 patients in validation group were enrolled. Female gender (odds ratio [OR] = 6.4; P < 0.001), allergic rhinitis (OR = 2.9; P = 0.021), serum total (T)-immunoglobulin (Ig) E ≥ 69.0kU/L (OR = 12.0; P < 0.001), and blood eosinophil count ≥ 0.35 × 109/L (OR = 4.0; P = 0.001) were shown to be independent risk factors for asthma in patients with CRSwNP. Based on these variables, a scoring system (FAIE) ranging from 0(no risk) to 6(high risk); was developed. The area under the receiver operating characteristic curve of the system was 0.823, and the optimal cut-off value was 3 points, with sensitivity 83.8% and specificity 68.6% for screening asthma. The asthma comorbidity determined with FAIE score ≥ 3 points in the validation group, was moderately consistent with that defined by GINA (Kappa = 0.513, P < 0.001), with sensitivity 76.9% and specificity 74.4%. Conclusions Female gender, allergic rhinitis, serum T-IgE level, and blood eosinophil count are independent risk factors for asthma comorbidity in patients with CRSwNP, and the FAIE system may be practical for screening comorbid asthma in these patients.

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Section: Discussionmentioning

confidence: 99%