Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations

Yılmaz, Seda Güleç; Gül, Tuğçe; Attar, Rukset; Yıldırım, Gazi; İsbır, Turgay

doi:10.4274/jtgga.2018.0002

Cited by 10 publications

(8 citation statements)

References 20 publications

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“…Despite the positive results regarding the increased risk for UFs in the selected VDR polymorphisms obtained by Shahbazi [ 15 ] and Gulec Yilmaz et al [ 33 ], our larger sample size study did not confirm these findings. The difference may have resulted from the ethnicity of the investigated populations.…”

Section: Discussioncontrasting

confidence: 90%

“…On the other hand, Anderson et al found an association between rs2228570 and reduced risk of breast cancer [ 57 ]. Finally, in his recent publication, Shahbazi found that rs2228570 was associated with UF development in Iranian women [ 15 ], which is consistent with the recent analysis performed on Turkish women [ 33 ]. Moreover, the importance of rs2228570 polymorphism has been shown in Saudi breast cancer patients [ 58 ].…”

Section: Discussionsupporting

confidence: 81%

“…Both rs731236 and rs1544410 were found to be useful predictors of genetic susceptibility for earlier surgical menopause [ 32 ]. According to Shahbazi and Gulec Yilmaz et al , certain haplotypes of rs2228570 are associated with an elevated risk for UFs in Iranian and Turkish populations, respectively [ 15 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D receptor gene polymorphisms and uterine fibroid incidence in Caucasian women

Ciebiera¹,

Wrzosek²,

Wojtyła³

et al. 2019

Arch Med Sci

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Introduction: Uterine fibroids (UFs) are benign tumors which are derived from the smooth muscle cells of the uterus. Recent studies have demonstrated that the development of UFs can be particularly related to vitamin D and its receptor. Vitamin D comprises a group of fat-soluble steroid compounds which exert powerful, pleiotropic effects all over the human body. These actions are mediated by a specific type of receptor-vitamin D receptor (VDR). Recent findings have focused on the possible role of VDR genetic variations in the development of several types of diseases, e.g. autoimmune system diseases, various cancers and infections. Material and methods: The aim of the study was to evaluate the association between rs731236, rs1544410, and rs2228570 polymorphisms in the VDR (vitamin D receptor) gene and the incidence of UFs in Caucasian women. A total of 197 patients (114 fibroid-positive and 83 controls) were included in this retrospective cohort study. VDR gene polymorphisms rs731236 (TaqI), rs1544410 (BsmI) and rs2228570 (FokI) were determined using TaqMan and Simple Probes. Results: No statistically significant differences in the occurrence of selected VDR polymorphisms were observed between UF-positive women and healthy controls. Conclusions: We found no association between rs731236, rs1544410, and rs2228570 VDR polymorphisms and UF incidence in Caucasian women. Larger sample size and multi-ethnic studies are necessary to investigate the matter further.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionsupporting

confidence: 81%

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Vitamin D receptor gene polymorphisms and uterine fibroid incidence in Caucasian women

Ciebiera¹,

Wrzosek²,

Wojtyła³

et al. 2019

Arch Med Sci

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show abstract

“…The study by Shahbazi et al supports the hypothesis that UFs are associated with the VDR rs2228570 polymorphism—correlation between VDR TT genotype and UF occurrence risk [ 121 ]. More recently (2018), Yilmaz et al demonstrated that the presence of the rs2228570 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for the development of UFs, which is consistent with the findings of Shahbazi [ 122 ]. Both studies had limitations: small sample size and closed populations and their results need to be confirmed on larger populations [ 120 ].…”

Section: Discussionsupporting

confidence: 62%

Vitamin D and Uterine Fibroids—Review of the Literature and Novel Concepts

Ciebiera

Włodarczyk

Ciebiera

et al. 2018

IJMS

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This article provides a detailed review of current knowledge on the role of vitamin D and its receptor in the biology and management of uterine fibroids (UFs). Authors present ideas for future steps in this area. A literature search was conducted in PubMed using the following key words: “uterine fibroid” and “vitamin D”. The results of the available studies, published in English from January 2002 up to April 2018, have been discussed. Vitamin D is a group of steroid compounds with a powerful impact on many parts of the human body. This vitamin is believed to regulate cell proliferation and differentiation, inhibit angiogenesis, and stimulate apoptosis. Nowadays, hypovitaminosis D is believed to be a major risk factor in the development of UFs. In many studies vitamin D appears to be a powerful factor against UFs, resulting in inhibition of tumor cell division and a significant reduction in its size, however, the exact role of this compound and its receptor in the pathophysiology of UFs is not fully understood. According to available studies, vitamin D and its analogs seem to be promising, effective, and low-cost compounds in the management of UFs and their clinical symptoms, and the anti-tumor activities of vitamin D play an important role in UF biology. The synergy between vitamin D and selected anti-UF drugs is a very interesting issue which requires further research. Further studies about the biological effect of vitamin D on UF biology are essential. Vitamin D preparations (alone or as a co-drugs) could become new tools in the fight with UFs, with the additional beneficial pleiotropic effect.

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“…Recently, several genetic mutations have been known in the vitamin D receptor (VDR). One of them, among many others, is the Fok1 single nucleotide polymorphism that has been linked to gynecological disorders as uterine leiomyoma and polycystic ovary (26,27). Hussain et al according to a study on 340 female students from the Dubai Medical University reported that the frequency of F-containing genotypes between VDR Fok1 genotypes (FF, Ff, and ff) was significantly higher among the PMS group (56.8%) than the control group (44.1%).…”

Section: Discussionmentioning

confidence: 99%

Comparison of serum level of some trace elements and vitamin D between patients with premenstrual syndrome and normal controls: A cross-sectional study

Fatemi

Allahdadian

Bahadorani

2019

IJRM

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Background: Premenstrual syndrome (PMS) is a common problem among women and is identified by reversal emotional, psychological, and physical signs during the luteal phase. These signs, however, lower down in the follicular phase. The cause of PMS isn’t very well-known up to now control group and many researchers have suggested that mineral compounds and vitamins can inhibit these symptoms. Objective: The objective of this study is to compare the serum level of some trace elements and vitamin D between normal controls and patients with PMS. Materials and Methods: 300 female students (19–21 yr old) from Falavarjan County were randomly selected and asked to complete a standard questionnaire on PMS during three menstruation cycles. The students were divided into two groups: healthy persons (control) and PMS persons, and PMS was determined on the basis of the answers to the questionnaire. Thereafter, the serum concentrations of zinc, iron, calcium, magnesium, potassium, sodium, and Vitamin D3 were measured and compared between the two groups. Results: Our results showed that the PMS prevalence was about 41.5%. The level of vitamin D decreased in both the control and PMS groups, with a significantly lower range of vitamin D (p 0.05) in the PMS group. Other factors had no significant change between the two groups. Conclusion: Vitamin D deficiency was probably one of the most important causes of unpleasant symptoms of PMS between these students. Key words: Premenstrual syndrome, Trace elements, Vitamin D.

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Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations

Cited by 10 publications

References 20 publications

Vitamin D receptor gene polymorphisms and uterine fibroid incidence in Caucasian women

Vitamin D receptor gene polymorphisms and uterine fibroid incidence in Caucasian women

Vitamin D and Uterine Fibroids—Review of the Literature and Novel Concepts

Comparison of serum level of some trace elements and vitamin D between patients with premenstrual syndrome and normal controls: A cross-sectional study

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