Association between FKBP5 polymorphisms and depressive disorders or suicidal behavior: A systematic review and meta-analysis study

Hernández‐Díaz, Yazmín; González‐Castro, Thelma Beatriz; Tovilla-Zárate, Carlos Alfonso; Juárez‐Rojop, Isela Esther; López‐Narváez, María Lilia; Pérez-Hernández, Nonanzit; Rodríguez-Pérez, José Manuel; Genis‐Mendoza, Alma Delia

doi:10.1016/j.psychres.2018.12.066

Cited by 32 publications

(24 citation statements)

References 39 publications

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“…Interestingly, in the present study a higher number of the major C allele was found to be associated with more depressive symptoms in the sample of CHD patients, while the majority of previous studies found the minor T allele to confer risk of mood and anxiety disorders (Hernandez-Diaz et al 2019;Zannas et al 2016). However, in line with the present findings, several studies reported an association of the major alleles of FKBP5 SNPs with depression (Zobel et al 2010), suicidal events in depressed patients (Brent et al 2010), and more depressive symptoms in male adolescents in the context of victimization (VanZomeren-Dohm et al 2015).…”

Section: Discussioncontrasting

confidence: 74%

Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

et al. 2020

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Depression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a central element of the stress system, the FKBP5 gene has been shown to be associated with depression. In a prospective design, this study aims to investigate the association of FKBP5 with depressive symptoms in CHD patients. N = 268 hospitalized CHD patients were included. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS-D) at four time points (baseline, and after 1 month, 6 months, and 12 months). The functional FKBP5 single-nucleotide polymorphism (SNP) rs1360780 was selected for genotyping. Linear regression models showed that a higher number of FKBP5 C alleles was associated with more depressive symptoms in CHD patients both at baseline (p = 0.015) and at 12-months follow-up (p = 0.025) after adjustment for confounders. Further analyses revealed that this effect was driven by an interaction of FKBP5 genotype with patients' prior CHD course. Specifically, only in patients with a prior myocardial infarction or coronary revascularization, more depressive symptoms were associated with a higher number of C alleles (baseline: p = 0.046; 1-month: p = 0.026; 6-months: p = 0.028). Moreover, a higher number of C alleles was significantly related to a greater risk for dyslipidemia (p = .016). Our results point to a relevance of FKBP5 in the association of the two stress-related diseases depression and CHD.

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Section: Discussioncontrasting

confidence: 74%

Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

et al. 2020

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“…Overall, suicidality is indeed a highly complex and multifaceted phenomenon in which a large plethora of mechanisms and processes could be variable implicated, including the dysregulation of HPA activity, genetic load, epigenetics, cholesterol and triglyceride profile, specific neurocognitive and neuropsychological impaired domains, some personality traits and characters, sometimes state-dependent, and so on. 8,23,41,43,65,78,110,112,114,128,130,144,145,148,150,175,176 However, somewhat contrasting and sometimes inconclusive findings have been so far published, by enlarging the plethora of research fields yet to be furtherly deepened and investigated in the field of suicide risk amongst MDD subjects. As abovementioned, great deal of research has focused on dysfunction of the HPA axis and on alterations of main neurotransmitter system as well as a set of neuro-inflammatory modulators, even though concluding findings are still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…38 FKBP5 SNPs have been associated with an increased risk of MDD and SA. [39][40][41][42][43] Amongst the serotonin system candidate genes for SB, many genetic association studies have focused on the SLC6A4 (Solute Carrier Family 6, Member 4) gene, 44,45 located on chromosome 17 (17q11.2) which encodes for the serotonin transporter, a transmembrane presynaptic protein involved in the reuptake of the released serotonin from the synaptic cleft. 46 Moreover, the transcriptional activity of SLC6A4 gene is modulated by a 44 base-pair insertion/deletion polymorphism, commonly known as 5-HTTL-PR (serotonin transporter linked polymorphic region polymorphism-rs4795541), located upstream of the transcription start site.…”

Section: Genetic Vulnerability and Epigenetic Modulationmentioning

confidence: 99%

Understanding the Complex of Suicide in Depression: from Research to Clinics

Orsolini

Latini²,

Pompili³

et al. 2020

Psychiatry Investig

238

167

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Objective Amongst psychiatric disorders, major depressive disorder (MDD) is the most prevalent, by affecting approximately 15–17% of the population and showing a high suicide risk rate equivalent to around 15%. The present comprehensive overview aims at evaluating main research studies in the field of MDD at suicide risk, by proposing as well as a schematic suicide risk stratification and useful flow-chart for planning suicide preventive and therapeutic interventions for clinicians.Methods A broad and comprehensive overview has been here conducted by using PubMed/Medline, combining the search strategy of free text terms and exploded MESH headings for the topics of ‘Major Depressive Disorder’ and ‘Suicide’ as following: ((<i>suicide</i> [Title/Abstract]) AND (<i>major depressive disorder</i> [Title/Abstract])). All articles published in English through May 31, 2019 were summarized in a comprehensive way.Results Despite possible pathophysiological factors which may explain the complexity of suicide in MDD, scientific evidence supposed the synergic role of genetics, exogenous and endogenous stressors (i.e., interpersonal, professional, financial, as well as psychiatric disorders), epigenetic, the hypothalamic-pituitary-adrenal stress-response system, the involvement of the monoaminergic neurotransmitter systems, particularly the serotonergic ones, the lipid profile, neuro-immunological biomarkers, the Brain-derived neurotrophic factor and other neuromodulators.Conclusion The present overview reported that suicide is a highly complex and multifaceted phenomenon in which a large plethora of mechanisms could be variable implicated, particularly amongst MDD subjects. Beyond these consideration, modern psychiatry needs a better interpretation of suicide risk with a more careful assessment of suicide risk stratification and planning of clinical and treatment interventions.

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“…A Korean study of over 12 000 females showed a direct association between sleep deprivation and suicide, and there is a need for more research into the relationship (Park, Yang, & Kim, ). The role of genetics has also been studied, particularly the association with polymorphism FK506 and other genetic mutations with the emergence of suicidal thoughts and ideas (Hernández‐Diaz, González‐Castro, Tovilla‐Zárate, et al, ), but the sample sizes are not large enough to draw definitive conclusions so more research is required.…”

Section: Summary Of Findingsmentioning

confidence: 99%

Preventing suicide, promoting resilience: Is this achievable from a global perspective?

Ivbijaro

Kolkiewicz

Goldberg

et al. 2019

Asia-Pacific Psychiatry

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Suicide continues to be a major health concern globally despite many initiatives to identify risk factors and methods for suicide prevention. We have carried out a detailed narrative review of the literature from 2016 to 2019 using the headings of Personal resilience (P1), People (P2), Places (P3), Prevention (P4), Promoting collaboration (P5), and Promoting research (P6) in order to support an integrated approach to suicide prevention and the promotion of personal and population resilience. We have made 10 key recommendations on how this can be moved forward.

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Association between FKBP5 polymorphisms and depressive disorders or suicidal behavior: A systematic review and meta-analysis study

Cited by 32 publications

References 39 publications

Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

Understanding the Complex of Suicide in Depression: from Research to Clinics

Preventing suicide, promoting resilience: Is this achievable from a global perspective?

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