Association between financial toxicity and health-related quality of life of patients with gynecologic cancer

Kajimoto, Yusuke; Honda, Kazuo; Suzuki, Shiro; Mori, Masahiko; Tsubouchi, Hirofumi; Nakao, Kohshiro; Azuma, Anri; Shibutani, Takashi; Nagao, Shoji; Koyanagi, Takahiro; Kohara, Izumi; Tamaki, Shuko; Yabuki, Midori; Teng, Lida; Igarashi, Ataru

doi:10.1007/s10147-023-02294-1

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…Additionally, we found that patients' FT could predict their life quality directly, indicating that the alleviation of FT would be conductive to higher levels of QOL. This conclusion supports earlier ndings in samples of testicular cancer survivors and gynecologic cancer patients [14,44]. Such an association could be explained by the following two ways.…”

Section: Discussionsupporting

confidence: 92%

“…And each item was given on a Likert-type format with 5 options (1 = none of the time, 5 = all of the time). The total score ranges from 10 to 50, with the following stages: none (10)(11)(12)(13)(14)(15)(16)(17)(18)(19), mild (20)(21)(22)(23)(24)(25)(26)(27)(28)(29), moderate (30)(31)(32)(33)(34)(35)(36)(37)(38)(39), and severe (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50). Wu and Jiang translated it into Chinese with satisfactory internal consistency coe cient (Cronbach's α = 0.91) [38].…”

Section: Self-perceived Burden Scale (Spbs)mentioning

confidence: 99%

“…A multitude of studies have identi ed the multitudinous predictors of QOL among cancer patients. Among them, nancial toxicity (FT), de ned as the objective nancial burden and subjective nancial distress of patients with cancer because of treatments using innovative drugs and concomitant health service [12], seems to be a relatively new factor related to QOL of cancer populations [13,14]. The word " toxicity " is utilized because the nancial cost of cancer treatment can cause clinically side effects that is comparable to physical or psychological toxicities [15].…”

Section: Introductionmentioning

confidence: 99%

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Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Zhang,

Xu,

Yang

et al. 2024

Preprint

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Background Although immunotherapy has the potential to prolong the median survival time and overall survival of patients with lung cancer, it is also a driver of immune related adverse events, which may directly affect the therapeutic effect and reduce quality of life (QOL). Attention to measure QOL in lung cancer patients undergoing immunotherapy is under-explored because of the therapy’s relative novelty. And a great deal of empirical researches has indicated the important influence of financial toxicity (FT) and self-perceived burden (SPB) on QOL. However, yet no research has ever clarified the relationship among FT, SPB, and QOL simultaneously. Hence, the purpose of this study is to understand the level of QOL of lung cancer patients undergoing immunotherapy, and attempt to clarify the potential mediating roles of SPB on the relationship between FT and QOL. Methods A convenience sample of 342 lung cancer patients undergoing immunotherapy was recruited from a cancer hospital from October 2022 to April 2023 in this cross-sectional study. Participants were requested to complete the structured questionnaires: sociodemographic and clinical questionnaire, Functional Assessment of Cancer Therapy–Lung (FACT-L), Self -Perceived Burden Scale (SPBS) and COmprehensive Score for financial Toxicity (COST). Data were subjected to Pearson correlation analysis and bootstrapping analysis in the structural equation modelling. Results The total score of FACT-L was (79.90 ± 15.84) points in 322 lung cancer patients administrated with immunotherapy. FT (β = 0.37, P < 0.01) and SPB (β = -0.27, P < 0.01) had a direct effect on QOL. In addition, SPB partly mediated the association between FT and QOL, and the standardized indirect effect was 0.19, accounting for 33.9% of the total effect. Conclusions The present study revealed that lung cancer patients undergoing immunotherapy experienced a lower QOL. And higher financial burden resulted in greater self-perceived burden, thus associated with inferior QOL. It is imperative for healthcare providers to routinely assessed QOL, financial toxicity or risk and self- perceived burden for lung cancer patients undergoing immunotherapy, and assist those patients in understanding the potential financial risk of each choice and help them take more active roles in their routine clinical care.

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Section: Discussionsupporting

confidence: 92%

Section: Self-perceived Burden Scale (Spbs)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Zhang,

Xu,

Yang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The COST scale, according to the developer’s definition, produces a continuous variable ranging from 0 to 44. Smaller values signify a higher degree of FT [ 26 – 28 ], resulting in the following formula for FT calculation: FT = 44 − COST. Additionally, FT was stratified into four grades based on the developer’s guidance: G0, no FT, COST ≥ 26; G1, mild FT, COST between 14 and 26; G2, moderate FT, COST > 0 and up to 14; and G3, severe FT, COST = 0 [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Factors associated with financial toxicity in patients with breast cancer in Japan: a comparison of patient and physician perspectives

et al. 2023

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Background Financial toxicity (FT) is a notable concern for patients with breast cancer worldwide. The situation regarding FT in Japan, however, has not been well explored. This study examined FT in patients with breast cancer in Japan and presented an overview of the group study’s overall findings. Methods The survey used the Questant application and primarily targeted patients with breast cancer attending research facilities and physicians who are members of the Japanese Breast Cancer Society. The Japanese version of the Comprehensive Score for FT (COST) was used to quantify patients’ FT. Multiple regression analysis was used to identify factors related to FT in patients with breast cancer in Japan and evaluate the sufficiency of information support level (ISL) for medical expenses. Results We collected 1558 responses from patients and 825 from physicians. In terms of factors affecting FT, recent payments had the highest impact, followed by stage, and related departments positively affecting FT. Conversely, factors such as income, age, and family support were found to negatively affect FT. A significant discrepancy was identified between patients and physicians in perceived information support, with patients frequently feeling unsupported and physicians believing that they have provided adequate support. Furthermore, differences in the frequency of explanations and opportunities to ask questions about medical costs across FT grades were found. The analysis also showed that physicians with a better understanding of information support needs and greater knowledge of medical costs tended to provide more support that is comprehensive. Conclusion This study emphasizes the importance of addressing FT in patients with breast cancer in Japan and highlights the need for enhanced information support, deeper understanding by physicians, and collaborative efforts among professionals to mitigate financial burden and provide personalized, tailored support for individual needs.

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“…This evaluation has given rise to the term financial toxicity, which has been used to describe the personal financial burden faced by patients receiving cancer treatment [5,6]. Previous reports suggested links among financial toxicity, higher mortality, and health-related quality of life (HRQOL) [6][7][8][9]. de Souza et al [10] developed and validated the COmprehensive Score for financial Toxicity (COST) to measure financial toxicity.…”

Section: Introductionmentioning

confidence: 99%

Financial Toxicity in Japanese Patients with Metastatic Renal Cell Carcinoma: A Cross-Sectional Study

Kimura,

Fujii,

Honda

et al. 2024

Cancers

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Information on the financial toxicity experienced by Japanese patients with metastatic renal cell carcinoma (mRCC) is lacking, even though Japan has its own unique public health insurance system. Thus, a web-based survey was conducted to evaluate the financial toxicity experienced by Japanese mRCC patients using the COmprehensive Score for financial Toxicity (COST) tool. This study enrolled Japanese patients who underwent, or were undergoing, systemic therapy for mRCC. The outcomes evaluated were the distribution of COST scores, the correlation between COST and quality of life (QOL) assessed by the Functional Assessment of Cancer Therapy-General (FACT-G) scale, and demographic factors associated with financial toxicity. The median (range) COST score was 19.0 (3.0–36.0). The Pearson correlation coefficient for COST and FACT-G total scores was 0.40. Univariate analysis revealed that not having private health insurance and lower household income per year were significantly associated with lower COST scores. Multivariate analyses showed that age < 65 years and not having private health insurance were significantly associated with lower COST scores. This study revealed that Japanese mRCC patients experience adverse financial impacts even under the universal health insurance coverage system available in Japan, and financial toxicity negatively affects their QOL.

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Association between financial toxicity and health-related quality of life of patients with gynecologic cancer

Cited by 5 publications

References 34 publications

Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Factors associated with financial toxicity in patients with breast cancer in Japan: a comparison of patient and physician perspectives

Financial Toxicity in Japanese Patients with Metastatic Renal Cell Carcinoma: A Cross-Sectional Study

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