Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis

Park, Soonchan; Lee, Miji; Cho, Kyung–Ja; Kim, Sung‐Bae; Roh, Jong–Lyel; Choi, Seungho; Nam, Soon Yuhl; Kim, Sang Yoon; Song, Joon Seon

doi:10.1369/0022155418761652

Cited by 4 publications

(5 citation statements)

References 69 publications

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“…E5 also blocks degradation of EGFR proteins, perhaps by manipulation of the cytoskeleton or decreasing acidity inside of lysosomes [40]. Amplification of other growth factors, namely fibroblast growth factor receptor 1, has been implicated in pathogenesis of tonsillar SCC, but this is not limited to HPV-positive cases [60]. Additionally, E5 down regulates CD-1d and MHC to avoid identification by natural killer cells and cytotoxic T cells [45].…”

Section: Cellullar Mechanisims Of Hpv-mediated Oropharyngeal Carcinog...mentioning

confidence: 99%

It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer

McKeon

Gallant

Kim

et al. 2022

Cancers

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While the two primary risk factors for head and neck squamous cell carcinoma (HNSCC) are alcohol and tobacco, viruses account for an important and significant upward trend in HNSCC incidence. Human papillomavirus (HPV) is the causative agent for a subset of oropharyngeal squamous cell carcinoma (OPSCC)—a cancer that is impacting a rapidly growing group of typically middle-aged non-smoking white males. While HPV is a ubiquitously present (with about 1% of the population having high-risk oral HPV infection at any one time), less than 1% of those infected with high-risk strains develop OPSCC—suggesting that additional cofactors or coinfections may be required. Epstein–Barr virus (EBV) is a similarly ubiquitous virus that is strongly linked to nasopharyngeal carcinoma (NPC). Both of these viruses cause cellular transformation and chronic inflammation. While dysbiosis of the human microbiome has been associated with similar chronic inflammation and the pathogenesis of mucosal diseases (including OPSCC and NPC), a significant knowledge gap remains in understanding the role of bacterial-viral interactions in the initiation, development, and progression of head and neck cancers. In this review, we utilize the known associations of HPV with OPSCC and EBV with NPC to investigate these interactions. We thoroughly review the literature and highlight how perturbations of the pharyngeal microbiome may impact host-microbiome-tumor-viral interactions—leading to tumor growth.

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Section: Cellullar Mechanisims Of Hpv-mediated Oropharyngeal Carcinog...mentioning

confidence: 99%

It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer

McKeon

Gallant

Kim

et al. 2022

Cancers

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“…28 The prognostic value of FGFR1 amplification in HNSCC is debatable, and recently, more studies reported that FGFR1 amplification is not related to patient overall survival. 29,30 One of the plausible explanations is that FGFR1 amplification is not associated with FGFR1 expression level. 25,30 On the other hand, FGFR1 overexpression has been observed in ~10% to 82% of HNSCC patients, 26,31,32 and there is no difference in FGFR1 expression between HPV-positive and HPV-negative HNSCC patients.…”

Section: Fgfr1 Amplification and Overexpressionmentioning

confidence: 99%

“…29,30 One of the plausible explanations is that FGFR1 amplification is not associated with FGFR1 expression level. 25,30 On the other hand, FGFR1 overexpression has been observed in ~10% to 82% of HNSCC patients, 26,31,32 and there is no difference in FGFR1 expression between HPV-positive and HPV-negative HNSCC patients. 25 However, at present, conflicting results in terms of FGFR1 expression as a prognosis biomarker have been reported.…”

Section: Fgfr1 Amplification and Overexpressionmentioning

confidence: 99%

“…In addition, FGFR1 and FGFR3 amplifications have also been observed in some rare HNSCCs, such as external auditory canal SCC 28 . The prognostic value of FGFR1 amplification in HNSCC is debatable, and recently, more studies reported that FGFR1 amplification is not related to patient overall survival 29,30 . One of the plausible explanations is that FGFR1 amplification is not associated with FGFR1 expression level 25,30 .…”

Section: Fgfr Genomic Alterations In Hnsccmentioning

confidence: 99%

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Therapeutic Targeting of FGFR Signaling in Head and Neck Cancer

Wang¹,

Anderson

2022

Cancer J

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Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most prevalent cancer worldwide, with an annual incidence of 600,000 new cases. Despite advances in surgery, chemotherapy, and radiotherapy, the overall survival for HNSCC patients has not been significantly improved over the past several decades. Fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) genomic alterations are frequently detected in HNSCC, including amplification, activating mutation, and chromosomal rearrangement. Among them, FGFR1 amplification, FGF amplifications, and FGFR3 mutations are the most prevalent. In addition, FGF/FGFR expression has also been observed in most HNSCCs. However, the prognostic value of FGF/FGFR aberrations remains unclear, especially for gene amplification and overexpression. Nonetheless, FGF/FGFR has been a promising target for HNSCC treatment, and recent preclinical studies demonstrate the potential of the combination treatment regimens involving FGFR inhibitors on HNSCC. Therefore, there are a number of FGFR inhibitors currently in clinical trials for the treatment of head and neck cancers.

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“…E5 also blocks degradation of EGFR proteins, perhaps by manipulation of the cytoskeleton or decreasing acidity inside of lysosomes [31]. Amplification of other growth factors, namely fibroblast growth factor receptor 1, has been implicated in pathogenesis of tonsillar SCC, but this is not limited to HPV-positive cases [44].…”

Section: Cellullar Mechanisims Of Hpv-mediated Oropharyngeal Carcinog...mentioning

confidence: 99%

It Takes Two to Tango; A Review of Oncogenic Virus and Host Microbiome Associated Inflammation on Head and Neck Cancer

McKeon¹,

Gallant²,

Kim³

et al. 2022

Preprint

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While the two primary risk factors for head and neck squamous cell carcinoma (HNSCC) are alcohol and tobacco, viruses account for an important and significant upward trend in HNSCC incidence. Human papillomavirus (HPV) is the causative agent for a subset of oropharyngeal squamous cell carcinoma (OPSCC)—a cancer that is impacting a rapidly growing group of typically middle-aged non-smoking white males. While HPV is a ubiquitously present virus (with about 7% of the population having oral HPV infection at any one time), only 1% of those infected develop OPSCC— suggesting that additional cofactors or coinfections may be required. Epstein-Barr virus (EBV) is a similarly ubiquitous virus that is strongly linked to nasopharyngeal carcinoma (NPC). Both of these viruses cause cellular transformation and chronic inflammation. While dysbiosis of the human microbiome has been associated with similar chronic inflammation and the pathogenesis of mucosal diseases (including OPSCC and NPC), a significant knowledge gap remains in understanding the role of bacterial-viral interactions in the initiation, development, and progression of head and neck cancers. In this review, we utilize the known associations of HPV with OPSCC and EBV with NPC to investigate these interactions. We thoroughly review the literature and highlight how perturbations of the pharyngeal microbiome may impact host-microbiome-tumor-viral interactions—leading to tumor growth.

show abstract

Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis

Cited by 4 publications

References 69 publications

It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer

It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer

Therapeutic Targeting of FGFR Signaling in Head and Neck Cancer

It Takes Two to Tango; A Review of Oncogenic Virus and Host Microbiome Associated Inflammation on Head and Neck Cancer

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