Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease

Xu, Sicheng; Kuang, Jiangying; Liu, Jin; Ma, Chunlan; Feng, Yu; Su, Zhiguang

doi:10.1038/aps.2012.69

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…General characteristics of the subjects The baseline characteristics, the biochemical features and the results of the pulmonary function tests of the subjects in this study have been reported in our previous articles [12,21,22] and are presented in supplementary Table S2. All patients had FEV1 values <80% of predicted, and thus were diagnosed with moderate to severe COPD according to the Global Initiative for Chronic Obstructive Lung Disease [23] (classification of severity: mild=FEV1≥80% of predicted; moderate=FEV1≥50% to <80% of predicted; severe=FEV1≥30% to <50% of predicted; and very severe=FEV1<30% of predicted).…”

Section: Resultsmentioning

confidence: 99%

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Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Yuan

Zhang

et al. 2016

Acta Pharmacol Sin

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Aim: Adiponectin has been implicated in the development of chronic obstructive pulmonary disease (COPD). The CDH13 gene encodes T-cadherin that is an adiponectin receptor, and genetic variants of CDH13 determine blood adiponectin levels. The aim of this study was to investigate the effects of CDH13 variants on COPD susceptibility in a Chinese population. Methods: Ten single-nucleotide polymorphisms (SNP) in CDH13 were screened using the SNaPshot method in 279 COPD patients and 367 control subjects. Association of genotypes or haplotypes constructed from these loci with COPD was analyzed in different genetic models. Results: Among the 10 SNPs tested, rs4783244 and rs12922394 exhibited significant differences in allele or genotype frequencies between COPD patients and control subjects, whereas 8 other SNPs did not. The minor allele T was associated with decreased risk of COPD in the recessive model at rs4783244 (OR=0.42, P=0.023) and in the dominant model at rs12922394 (OR=0.70, P=0.022). The genotype TT at either rs4783244 or rs12922394 was associated with a significantly low level of plasma adiponectin when compared to genotypes GG and CC (P<0.05). Haplotypes GC in block 1 (rs4783244-rs12922394) as well as GTAC and ATGT in block 3 (rs4783266-rs11640522-rs11646849-rs11860282) significantly increased the risk of COPD, whereas haplotypes TT in block 1, TG in block 2 (rs11646011-rs11640875) and ATGC in block 3 were protective against COPD. Conclusion: CDH13 genetic variants determine Chinese individuals' susceptibility to COPD and thus are efficient genetic biomarkers for early detection of COPD.

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Section: Resultsmentioning

confidence: 99%

“…The subjects in this study were recruited for our previous studies [12,21,22] . Briefly, we investigated 646 unrelated ethnic Han Chinese individuals including 279 COPD patients and 367 age-matched control individuals.…”

Section: Subjectsmentioning

confidence: 99%

Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Yuan

Zhang

et al. 2016

Acta Pharmacol Sin

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“…As described previously [23], 279 patients with COPD and 367 age-matched non-COPD control subjects were recruited for this study. The subjects in both groups were unrelated ethnic Han Chinese individuals recruited from Chengdu city or surrounding regions in the Sichuan province of western China.…”

Section: Methodsmentioning

confidence: 99%

Genetic Variations in ADIPOQ Gene Are Associated with Chronic Obstructive Pulmonary Disease

et al. 2012

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BackgroundAdiponectin is reported to be related to the development of chronic obstructive pulmonary disease (COPD). Genetic variants in the gene encoding adiponectin (ADIPOQ) have been reported to be associated with adiponectin level in several genome–wide linkage and association studies. However, relatively little is known about the effects of ADIPOQ gene variants on COPD susceptibility. We determined the frequencies of single-nucleotide polymorphisms (SNPs) in ADIPOQ in a Chinese Han population and their possible association with COPD susceptibility.MethodsWe conducted a case–control study of 279 COPD patients and 367 age- and gender-distribution-matched control subjects. Seven tagging SNPs in ADIPOQ, including rs710445, rs16861205, rs822396, rs7627128, rs1501299, rs3821799 and rs1063537 were genotyped by SNaPshot. Association analysis of genotypes/alleles and haplotypes constructed from these loci with COPD was conducted under different genetic models.ResultsThe alleles or genotypes of rs1501299 distributed significantly differently in COPD patients and controls (allele: P = 0.002, OR = 1.43 and 95%CI = 1.14–1.79; genotype: P = 0.008). The allele A at rs1501299 was potentially associated with an increased risk of COPD in all dominant model analysis (P = 0.009; OR: 1.54; 95%CI: 1.11–2.13), recessive model analyses (P = 0.015; OR: 1.75; 95% CI: 1.11–2.75) and additive model analyses (P = 0.003; OR: 2.11; 95% CI: 1.29–3.47). In haplotype analysis, we observed haplotypes AAAAACT and GGACCTC had protective effects, while haplotypes AGAACTC, AGGCCTC, GGAACTC, GGACACT and GGGCCTC were significantly associated with the increased risk of COPD.ConclusionsWe conducted the first investigation of the association between the SNPs in ADIPOQ and COPD risk. Our current findings suggest that ADIPOQ may be a potential risk gene for COPD. Further studies in larger groups are warranted to confirm our results.

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“…e potential of KGF to protect epithelial and mucosal tissues was indicated by its action of reducing the severity of mucositis after chemoradiotherapy. Although the beneficial mechanism of KGF in mucositis is generally attributed to protecting the integrity of the epithelial barrier, Gardner and colleagues believed since infection was the central pathogenesis of the disease that KGF may have antibacterial effects [13,51].…”

Section: Gubenzhike Recipe Can Promote Tissue Repair In Copdmentioning

confidence: 99%

Gubenzhike Recipe Ameliorates Respiratory Mucosal Immunity in Mice with Chronic Obstructive Pulmonary Disease through Upregulation of the γδT Lymphocytes and KGF Levels

Wang

Liu

Cai

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Gubenzhike recipe, a traditional Chinese herbal compound, was assumed to have a possible beneficial effect on COPD. This study was designed to elucidate the mechanism from the perspective of respiratory mucosal immunity. Methods. COPD model was induced by exposure to cigarette smoke and LPS instillation in mice for 12 weeks. Animals were administered solution of Gubenzhike recipe by intragastric gavage daily for 4 weeks. After that, mice were sacrificed for lung function test and histological examination of lung tissues. The levels of IL-6 and IL-13 in serum, bronchoalveolar lavage fluid (BALF), and intestinal mucus were measured by ELISA. The KGF and KGFR in lung tissue were analysed by immunohistochemical staining, ELISA, and western blotting, and the mRNA expressions were assessed by PCR. γδT lymphocytes in the lungs were isolated and analysed by immunohistochemical staining and flow cytometry. Results. Gubenzhike recipe improved the structure of airway and damage of lung tissue and also the respiratory status and lung function, reduced the content of IL-6 in serum and BALF and IL-13 in BALF and intestinal mucus, increased the proportion of γδT cells in lung tissue, and promoted the secretion of KGF and KGFR (P<0.05). Conclusion. We for the first time demonstrated an experimental procedure for the isolation of γδT lymphocytes from lung tissue. This study suggested that Gubenzhike recipe could enhance the respiratory mucosal immunity which provided experimental evidence for its effects of reinforcing “wei qi” by means of strengthening vital qi, tonifying spleen and kidney, relieving cough, and reducing phlegm in TCM.

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Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease

Cited by 11 publications

References 31 publications

Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Genetic Variations in ADIPOQ Gene Are Associated with Chronic Obstructive Pulmonary Disease

Gubenzhike Recipe Ameliorates Respiratory Mucosal Immunity in Mice with Chronic Obstructive Pulmonary Disease through Upregulation of the γδT Lymphocytes and KGF Levels

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