Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

Abstract

Although the fibrinogen-to-albumin ratio (F/R ratio) has been used as an inflammation marker to predict clinical outcomes in patients with cardiovascular diseases, its association with the prognosis of patients with coronavirus disease 2019 (COVID-19) remains unclear. Electronic databases including EMBASE, MEDLINE, Google Scholar, and Cochrane Library were searched from inception to 20 June 2022. The associations of F/R ratio with poor prognosis (defined as the occurrence of mortality or severe disease) were investigated in patients with COVID-19. A total of 10 studies (seven from Turkey, two from China, one from Croatia) involving 3675 patients published between 2020 and 2022 were eligible for quantitative syntheses. Merged results revealed a higher F/R ratio in the poor prognosis group (standardized mean difference: 0.529, p < 0.001, I2 = 84.8%, eight studies) than that in the good prognosis group. In addition, a high F/R ratio was associated with an increased risk of poor prognosis (odds ratio: 2.684, I2 = 59.5%, five studies). Pooled analysis showed a sensitivity of 0.75, specificity of 0.66, and area under curve of 0.77 for poor prognosis prediction. In conclusion, this meta-analysis revealed a positive correlation between F/A ratio and poor prognostic outcomes of COVID-19. Because of the limited number of studies included, further investigations are warranted to support our findings.

Impact of parental rheumatoid arthritis on risk of autism spectrum disorders in offspring: A systematic review and meta-analysis

“…First, genetic inheritance, which is considered to be one of most important causes of ASD, is supported by several studies that found a shared genetic liability between autoimmune diseases and ASD, such as human leukocyte antigen (HLA) alleles (33)(34)(35). Interestingly, this elevated risk in offspring ASD was less obvious or non-significant on paternal side as reported in previous studies (15,17,21,29) and also in our meta-analysis. Therefore, if shared common genetic paths are the main reason for the elevated risk, such a genetic influence seemed only to inherit through the maternal side.…”

“…Consistent with the results of a previous meta-analysis that demonstrated a 39% increase in risk of ASD in offspring of mothers diagnosed with ASD compared with those without RA (18), our study showed a 25% elevated risk. Compared with that study (18), the inclusion of five more studies (15,20,21,29,30) in the present meta-analysis provided more robust evidence to support such an elevated risk. Nevertheless, most of the new studies in the current meta-analysis were conducted in the same geographic locations as the previous meta-analysis (18), including Taiwan, U.S., and Denmark with only one new country (Finland) being included in our updated study.…”

“…Our analysis demonstrated no impact of paternal RA on the risk of offspring ASD (OR = 1.104, 95% CI: 0.932 to 1.309, Funnel plot demonstrating risk of publication bias. p = 0.253, I 2 = 2.127%) (Figure 4; 15,17,21,29). The pooled result was not significantly influenced by removing certain studies on sensitivity analysis.…”

Elevated Surgical Pleth Index at the End of Surgery Is Associated with Postoperative Moderate-to-Severe Pain: A Systematic Review and Meta-Analysis

“…The statistical analysis was previously reported in our studies [ 27 , 28 ]. The conversion of sensitivity/specificity or PPV/NPV into TP/TN/FP/FN was conducted with Review Manager version 5.3.…”

Fibrinogen level in coronary artery disease people with COVID-19 patients in Iraq

“…Humans and other mammals are frequently infected with coronaviruses, which are mammals and members of the Nidovirales order and the Coronaviridae family. (Huang et al 2020) Fibrinogen is a procoagulant protein molecule that consists of two outer D domains (Huang et al, 2022), the primary synthesized of Fibrinogen is start in liver hepatic parenchymal cells as a response to IL-1 and IL-6 derived stimulation and in the intracellular of endoplasmic reticulum (ER) assembled the final form of Fibrinogen (İlker Hayıroğlu et al, 2020), The increasing of Fibrinogen level in the blood is a serious matter and pathological indication, Fibrinogen is a vital protein plays a main role in blood clotting for survival as a result of fibrinogen catabolize fraction in ( I-6-I-9) process causes reduced turbidity, prolonged thrombin times and generate thinner fibers these thin fibers collect to form Fibrin clots (Sulimai et al, 2022). It has been demonstrated the value of fibrinogen as one of parameters in disseminated intravascular coagulation (DIC) and because the close relationship between COVID-19 and DIC the dynamic changes in fibrinogen levels are remarkable in COVID-19 patients when compared between COVID-19 patients with healthy controls it showed that the level of fibrinogen and it's degradation products is higher in COVID-19 patients (İlker Hayıroğlu et al, 2020).…”