Association between fibrinogen level and severity of postpartum haemorrhage: secondary analysis of a prospective trial

Abstract

The fibrinogen level at PPH diagnosis is a marker of the risk of aggravation and should serve as an alert to clinicians.

Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage

“…Fibrinogen depletion in early postpartum haemorrhage (PPH) was the single variable independently associated with progression to a severe PPH [4,5]. Early detection and aggressive correction of this depletion may be crucial to effective PPH management.…”

How I treat postpartum hemorrhage

“…25 A falling platelet count in early PPH 25 or a falling Clauss fibrinogen predict progression to transfusion and invasive procedures. 41,42 Our patient's first fibrinogen level was severely reduced at 0.2 g/L, an ominous sign of the course of events. However, the result was not available within a clinically useful time frame and it was the TEG results that prompted the need for cryoprecipitate.…”

Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study

“…13,14 Clauss fibrinogen, taken early during PPH, has been suggested as a biomarker to predict progression to transfusion and invasive procedures. [15][16][17] The evidence for this is limited, because the timing of the blood tests in previous studies has varied widely; the clinical status of the women was not fully described, and one study was a post hoc analysis of data collected for other reasons. 16 These limitations reduced clinical applicability.…”