Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11

Szternel, Lukasz; Krintus, Magdalena; Bergmann, Katarzyna; Dereziński, Tadeusz; Sypniewska, Grażyna

doi:10.3390/nu10101359

Cited by 13 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown a close relationship between vitamin D levels and glycolipid metabolism. Most observational studies have shown that vitamin D was negatively correlated with FPG, 21,[28][29][30] TG, 24,[28][29][30][31][32][33] TC, 28,30,34,35 LDL-C 24,28,31 and positively correlated with serum HDL-C. 24,28,31,34 Szternel et al 29 showed that serum vitamin D level was negatively correlated with FPG and TC in children aged 9-11 years, and every 1 ng/mL reduction in 25(OH)D concentration was associated with a 0.013 mmol/L increase in FPG, a 0.25 mmol/L increase in TC, and a 0.015 mmol/L decrease in HDL-C.…”

Section: Relationship Between 25(oh)d Level and Glucose And Lipid Metmentioning

confidence: 99%

<p>Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China</p>

Yang

Liu

et al. 2020

DMSO

View full text Add to dashboard Cite

Objective: To investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and blood glucose and lipid levels in people over 18 years of age in Gansu, China. Subjects and Methods: A total of 1928 volunteers (958 males and 970 females) were selected. The prevalence of abnormal glucose metabolism and lipid metabolism in the vitamin D deficiency group (<20 ng/mL) and the non-vitamin D deficiency group (≥20 ng/mL) were compared. The correlations between serum 25(OH)D and blood glucose and lipid were analyzed. Results: A total of 1681 patients had 25(OH)D deficiency, with an overall prevalence of 87.2% (82.9% in males and 91.4% in females). The levels of 25(OH)D in the diabetic group and the IGT/IFG group were significantly lower than that in the normal group. The level of 25(OH)D was significantly lower in the dyslipidemia group than that in the normal group, and was significantly lower in the fasting plasma glucose (FPG) ≥5.6 mmol/L group than that in the FPG <5.6 mmol/L group (p=0.002). The 25(OH)D level in the serum triglyceride (TG) ≥1.7 mmol/L group was significantly lower than that of the TG <1.7 mmol/L group (p=0.0274). The age, heart rate, TG, TC, FPG and H 2 PG levels in the vitamin D deficiency group were significantly higher than those in the non-vitamin D deficiency group (p<0.05). The prevalence of FPG ≥5.6 mmol/L in the vitamin D deficiency group was higher than that in the non-vitamin D deficiency group (23.5% vs 16.6%, p=0.016). Multiple linear regression analysis suggested that serum 25(OH)D levels were independently correlated with gender, age, FPG, TG and heart rate (β=−0.218, −0.129, −0.075, β=−0.103, −0.058, all p<0.05). Conclusion: The incidences of dyslipidemia and dysglycemia were higher in the vitamin D deficiency group. The vitamin D level was independently and negatively correlated with FPG and TC, but not with waist circumference, BMI and blood pressure.

show abstract

Section: Relationship Between 25(oh)d Level and Glucose And Lipid Metmentioning

confidence: 99%

<p>Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China</p>

Yang

Liu

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…However, this relationship was not observed with regard to HDL cholesterol in healthy subjects. Szternel et al, (14) showed that serum vitamin D level was negatively correlated with fasting blood glucose and total cholesterol in children aged 9-11 years, and every 1 ng/mL reduction in 25(OH)D concentration was associated with a 0.013 mmol/L increase in fasting blood glucose, a 0.25 mmol/L increase in total cholesterol and a 0.015 mmol/L decrease in HDL-cholesterol.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the observational studies have shown that vitamin D was negatively correlated with fasting blood glucose (12)(13)(14), total cholesterol, triglycerides, LDL-cholesterol and positively correlated with serum HDL-cholesterol (15)(16)(17)(18). In 2017, Ford et al, reported a negative relationship between 25(OH) D and triglycerides levels in hypotriglyceridemic patients (19).…”

Section: Discussionmentioning

confidence: 99%

Alternations in serum vitamin D, calcium, phosphorus and lipid profile levels in newly diagnosed type 2 diabetic patients of North-West India

Singh¹,

Khubchandani²,

Singh³

2021

Biomedicine

View full text Add to dashboard Cite

Introduction and Aim: Thirty-two million Indians are suffering with diabetes mellitus worldwide and predicted that this number of diabetes to be increased to 80 million by 2030. Many reports revealed a positive relationship between diabetic patients suffering with 25 (OH) D deficiency. In developing nations like India 60% adults were found showing manifestations of vitamin D deficiency and dyslipidemia, a well-known risk factor for the development of diabetes mellitus. Therefore, we designed the study to evaluate alterations in vitamin D, calcium, and phosphorus along with complete lipid profile levels in newly diagnosed type 2 diabetic patients in North-West Indians.Materials and Methods: One hundred fifty newly diagnosed type 2 diabetic patients and equal number of healthy control subjects of both genders were recruited in the study. 5ml of blood was collected by venipuncture after 12-14 hours fasting in plain and potassium oxalate: sodium fluoride vial. Serum and plasma were separated and used for the determination of 25(OH) D levels, calcium, phosphorus and complete lipid profile levels.Results: A significantly (p < 0.001) high level of glucose was observed in newly diagnosed type 2 diabetics subjects while a significant fall (p < 0.001) was recorded in vitamin D levels in newly diagnosed type 2 diabetics in comparison to healthy control subjects. The nominal changes were seen in calcium and phosphorus levels in newly diagnosed type 2 diabetics with respect to healthy control subjects. Statistically significant increase was found in total cholesterol (p < 0.05), triglyceride (p < 0.001) and VLDL-cholesterol (p < 0.001) levels while no significant changes was observed in LDL- cholesterol and HDL- cholesterol levels in newly diagnosed type 2 diabetics with respect to healthy subjects.Conclusion: Aforementioned observations suggested that a significant decrease in vitamin D levels was associated with increased glucose and lipid levels like total cholesterol, triglycerides and VLDL-cholesterol levels could be responsible for the initiation of various diseases like diabetes mellitus, cardiovascular diseases, osteoporosis etc. Hence, new interventions should be included as a part of treatment to reduce the risk of type-2 diabetics and CVDs like atherosclerosis

show abstract

“…However, in the other study, neither IGF-1 nor 25(OH)D correlated with the circulating markers of bone turnover P1NP (N-terminal propeptide of type I procollagen) and CTX-1 (C-terminal telopeptide of type I collagen) examined in prepubertal and pubertal children with sufficient vitamin D status [16]. Even though the high occurrence of vitamin D concentrations below 20 ng/mL (50 nmo/L) in European pediatric populations evidence seems insufficient to recommend a screening for vitamin D deficiency [17,18]. It is plausible that the association between IGF-I and markers of bone metabolism vary in children with low levels of 25(OH)D. We aimed to investigate the association of serum bone turnover markers (P1NP and CTX) with low 25(OH)D levels (<20 ng/mL), compared to their interaction with IGF-1.…”

Section: Introductionmentioning

confidence: 99%

Low Serum 25-hydroxyvitamin D Level Does Not Adversely Affect Bone Turnover in Prepubertal Children

Biliński¹,

Szternel

Siódmiak

et al. 2021

Nutrients

Self Cite

View full text Add to dashboard Cite

Both vitamin D and insulin-like growth factor 1 (IGF-1) play essential roles in bone metabolism and may interact during prepubertal bone accrual. We investigated the association of low serum 25-hydroxyvitamin D (25(OH)D) (<20 ng/mL) with the circulating bone turnover markers, when compared to their interaction with IGF-1. Subjects and Methods: Serum 25(OH)D, IGF-I, P1NP (N-terminal propeptide of type I procollagen), and CTX-1 (C-terminal telopeptide of type I collagen) were measured, and the bone turnover index (BTI) was calculated in 128 healthy children, aged 9–11 years. Results: Mean 25(OH)D concentration was 21.9 ± 4.9 ng/mL, but in 30.5% of participants it was <20 ng/mL (<50 nmol/L). We observed a trend for higher P1NP (p < 0.05) and IGF-1 (p = 0.08), towards lower 25(OH)D in tertiles. Levels of P1NP in the lowest 25(OH)D tertile (<20 ng/mL) were the highest, while CTX and BTI remained unchanged. Additionally, 25(OH)D negatively correlated with IGF-1, while the correlation with P1NP was not significant. A strong positive correlation of IGF-1 with P1NP and BTI but weak with CTX was observed. Low 25(OH)D (<20 ng/mL) explained 15% of the IGF-1 variance and 6% of the P1NP variance. Conclusions: Low levels of 25(OH)D do not unfavorably alter bone turnover. It seems that serum 25(OH)D level may not be an adequate predictor of bone turnover in children.

show abstract

Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11

Cited by 13 publications

References 20 publications

<p>Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China</p>

<p>Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China</p>

Alternations in serum vitamin D, calcium, phosphorus and lipid profile levels in newly diagnosed type 2 diabetic patients of North-West India

Low Serum 25-hydroxyvitamin D Level Does Not Adversely Affect Bone Turnover in Prepubertal Children

Contact Info

Product

Resources

About