Association between factor V Leiden mutation and recurrent pregnancy loss in the middle east countries: a Newcastle–Ottawa meta-analysis

Hamedi, Bahareh; Feulefack, Joseph; Khan, Aiza; Sergi, Consolato

doi:10.1007/s00404-020-05610-6

Cited by 12 publications

(13 citation statements)

References 58 publications

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“…The prevalence of thrombophilia in our cohort was 33.5% (58/175) with FVL to be the most prevalent thrombophilia detected (14.3% of cases). Similar rates of FVL incidence were reported in this population of women globally [15].…”

Section: Discussionsupporting

confidence: 85%

Reproductive Failure and Thrombophilia: Not Enough Evidence for a Tight Bond

et al. 2021

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Objectives: The role of hereditary thrombophilia in reproductive failure (RF) is strongly debatable. In this retrospective single-center study, we analyzed pregnancy outcome in 175 women screened for thrombophilia after at least one event of RF. Results: The prevalence of thrombophilia in our cohort was 33.4%. Pregnancy survival curves were not different according to severity (log-rank, p = 0.302) or type of thrombophilia (log-rank, p = 0.532). In total, 81.7% of 175 subsequent pregnancies were proceeded with LMWH. Concomitant use of ASA was prescribed in 75 pregnancies according to physician choice. The primary endpoint was live birth rate (LBR) that succeeded in 152/175 next pregnancies (86.8%) and late obstetric complications (LOBC) which occurred in 17/175 next pregnancies (9.8%). In logistic regression analysis, neither the severity nor the type of thrombophilia was important for any pregnancy outcome (LBR or LOBC). Considering therapeutic interventions, the use of LMWH ± ASA was not related to LBR or LOBC. The only factor inversely related to LBR was age above the cutoff value of 35.5 years (p = 0.049). Conclusions: Incidence of thrombophilia is increased among women with RF, but the severity or type of thrombophilia is not related to pregnancy outcome.

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Section: Discussionsupporting

confidence: 85%

Reproductive Failure and Thrombophilia: Not Enough Evidence for a Tight Bond

et al. 2021

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“…Our findings are in line with the data of three meta-analyses recently published in the literature that identified a significant association between PM or FVL and RSA. [5][6][7] The main mechanisms that may predispose to placenta-mediated pregnancy complications such as RSA, are thrombosis of placental vessels and abnormal placental development. 15 Nevertheless, there is no definitive consensus on the causal nexus between IT and RSA.…”

Section: Discussionmentioning

confidence: 99%

“…5 Furthermore, two metaanalyses by Sergi et al and Hamedi et al conducted on Middle Eastern women, found a significant association between FVL and RSA (OR 1.68; 95% CI, 1.16-2.44 and OR 2.37; 95% CI, 1.50-3.75), respectively. 6,7 Two small studies -in 2011 by Klai et al 8 and in 2013 by Akdemir et al 9 -previously found no significant association between RSA and non-O blood type, the most frequently inherited prothrombotic factor. 10 Therefore, we aimed to retrospectively evaluate the prevalence of non-O blood and IT in a large cohort of Italian women with early unexplained RSA.…”

Section: Introductionmentioning

confidence: 99%

Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia

Poretto

Borella

Turatti

et al. 2022

Bleed Thromb Vascul Biol

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We retrospectively evaluated the prevalence of non-O blood type – the most frequently inherited prothrombotic factor – and inherited thrombophilia (IT) in a group of women with recurrent spontaneous abortion (RSA). All consecutive women with a history of early unexplained RSA who underwent a screening for IT between December 2008 and December 2021 were considered for enrolment. A group of healthy, age-matched women with ≥1 normal pregnancy and no adverse pregnancy outcomes acted as controls. Two hundred and seventeen women were enrolled. The adjusted odds ratio (aOR) of RSA in non-O vs. O blood type was 1.37 (95% CI, 1.04-2.78), and in women with vs. without IT was 1.26 (95% CI, 1.08-3.61); aOR of RSA in women with non-O blood type and IT was 2.52 (95% CI, 1.12-5.47). We observed a significant association between non-O blood group or IT and RSA. The concomitant presence of non-O blood group and IT further increases RSA risk.

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“…Similarly, those with PTG mutation were twice as likely to experience RPL (odds ratio = 2.08) [ 37 ]. A recent meta-analysis of 19 case-control studies from Middle Eastern countries delineated that the prevalence of FVL mutation was 12.6% in patients with RPL loss compared to 4.9% in controls, with an odds ratio of 2.37 [ 38 ]. Yet another review in 2015 involving nine studies showed a statistically significant increased carrier frequency of FVL mutation with an odds ratio of 1.68 in women with recurrent first-trimester fetal losses [ 39 ].…”

Section: Reviewmentioning

confidence: 99%

Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome

Padda¹,

Khalid²,

Mohan³

et al. 2021

Cureus

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Factor V Leiden (FVL) G1619A mutation and prothrombin gene (PTG) G20210A are the most common inherited thrombophilias. They have been associated with various obstetric complications such as venous thromboembolism, recurrent pregnancy loss, preeclampsia, abruptio placentae, and small for gestational age fetus. The prevalence of these two mutations is 3-15% in Caucasians and is assumed to be far less common in other ethnic populations. However, there have been several controversies regarding advising routine screening of these thrombophilias because of a widely variable strength of association between different ethnic groups, as well as contradictory conclusions by different studies in regards to the association. In this study, the literature was analyzed thoroughly for the effect of FVL G1619A and PTG G20210A mutations on various obstetric outcomes. A review of multiple case-control and prospective studies suggests that despite the availability of robust data on this subject the results remain inconclusive and insubstantial. Further superior quality research, preferably prospective studies, is warranted to conclusively establish this relationship and to enable practitioners to follow a definitive protocol in the screening of various populations for these mutations to achieve an improved pregnancy outcome.

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Association between factor V Leiden mutation and recurrent pregnancy loss in the middle east countries: a Newcastle–Ottawa meta-analysis

Cited by 12 publications

References 58 publications

Reproductive Failure and Thrombophilia: Not Enough Evidence for a Tight Bond

Reproductive Failure and Thrombophilia: Not Enough Evidence for a Tight Bond

Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia

Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome

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