Association between exposure to different stone aggregates from asphalt and blood coagulability: A human exposure chamber study

Nitter, Therese Bergh; Hilt, Bjørn; Svendsen, Kristin; Buhagen, Morten; Jørgensen, Rikke Bramming

doi:10.1016/j.scitotenv.2021.146309

Cited by 5 publications

(7 citation statements)

References 51 publications

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“…In our early studies, feldspar content seemed to be inversely correlated to the pro-inflammatory potential of stone and mineral particles [45][46][47]. This has also found support in a recent clinical study where human volunteers exposed to quartz diorite particles showed stronger responses in terms of systemic markers of inflammation and blood coagulability than those exposed to rhomb porphyry particles with higher content of feldspar minerals [64,65]. Furthermore, the clinical study also showed a stronger response for exhaled nitric oxide in volunteers exposed to quartz diorite than rhomb porphyry [66].…”

Section: Pro-inflammatory Responses Of Road Tunnel Pm Compared To The...supporting

confidence: 70%

Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells

et al. 2022

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Background Traffic particulate matter (PM) comprises a mixture of particles from fuel combustion and wear of road pavement, tires and brakes. In countries with low winter temperatures the relative contribution of mineral-rich PM from road abrasion may be especially high due to use of studded tires during winter season. The aim of the present study was to sample and characterize size-fractioned PM from two road tunnels paved with different stone materials in the asphalt, and to compare the pro-inflammatory potential of these fractions in human bronchial epithelial cells (HBEC3-KT) in relation to physicochemical characteristics. Methods The road tunnel PM was collected with a vacuum pump and a high-volume cascade impactor sampler. PM was sampled during winter, both during humid and dry road surface conditions, and before and after cleaning the tunnels. Samples were analysed for hydrodynamic size distribution, content of elemental carbon (EC), organic carbon (OC) and endotoxin, and the capacity for acellular generation of reactive oxygen species. Cytotoxicity and pro-inflammatory responses were assessed in HBEC3-KT cells after exposure to coarse (2.5–10 μm), fine (0.18–2.5 μm) and ultrafine PM (≤ 0.18 μm), as well as particles from the respective stone materials used in the pavement. Results The pro-inflammatory potency of the PM samples varied between road tunnels and size fractions, but showed more marked responses than for the stone materials used in asphalt of the respective tunnels. In particular, fine samples showed significant increases as low as 25 µg/mL (2.6 µg/cm2) and were more potent than coarse samples, while ultrafine samples showed more variable responses between tunnels, sampling conditions and endpoints. The most marked responses were observed for fine PM sampled during humid road surface conditions. Linear correlation analysis showed that particle-induced cytokine responses were correlated to OC levels, while no correlations were observed for other PM characteristics. Conclusions The pro-inflammatory potential of fine road tunnel PM sampled during winter season was high compared to coarse PM. The differences between the PM-induced cytokine responses were not related to stone materials in the asphalt. However, the ratio of OC to total PM mass was associated with the pro-inflammatory potential.

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Section: Pro-inflammatory Responses Of Road Tunnel Pm Compared To The...supporting

confidence: 70%

Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells

et al. 2022

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“…The dust generation and exposure chamber have been described previously (18) and are not repeated here. The concentrations of total dust (stationary samples) and respirable dust (personal samples) were measured gravimetrically using a cyclone (SKC aluminum respirable cyclone) equipped with a cassette (SKC SureSeal 3-piece 37 mm) containing polyvinyl chloride (PVC) filters (SKC PVC filter 37 mm 5.0 μm).…”

Section: Assessing Exposurementioning

confidence: 99%

“…To extend this line of inquiry, we initiated a clinical study involving short-term exposure to two stone materials, quartz diorite and rhomb porphyry, used in road pavement. Using a human exposure chamber, we have observed limited systemic inflammatory and procoagulant responses following short-term exposure to quartz diorite in 24 healthy young volunteers (17,18). In this part of the study, we aimed to determine how inhalation of these stone materials influences pulmonary inflammation, lung function, and airway reactivity.…”

mentioning

confidence: 99%

Short-term exposure to stone minerals used in asphalt affect lung function and promote pulmonary inflammation among healthy adults

Moazami¹,

Hilt²,

Sørås³

et al. 2022

Scand J Work Environ Health

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Besides quartz and asbestos, less is known about the potential health effects of other mineral particles. This randomized, double-blind crossover study, including 24 healthy non-smoking volunteers, showed that the stone aggregate quartz diorite triggers pulmonary inflammation after short-term exposure. The stone aggregate rhomb porphyry was associated with a modest but statistically significant decline in lung function.

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“…The TSI 3410 Dust Aerosol Generator was used to force quartz diorite and rhomb porphyry into the exposure chamber, and the Aerosol Generator TSI 3400 was used to add lactose powder. Before each exposure session started, the belt speed and feed mass combination for the Dust Aerosol Generator and chamber ventilation was set so as to not exceed the Norwegian 8-h OELs for total dust (10 mg/m 3 ) and respirable dust (5 mg/m 3 ) exposure, respectively (Nitter et al, 2021). In particular, an air change rate (ACH) of 3.0/h was used during quartz diorite and rhomb porphyry exposure, and a belt speed between 10 and 11% was employed after the respirable dust fraction was recorded by the DustTrak.…”

Section: Calibration Of the Dust To Be Piped Into The Exposure Chambermentioning

confidence: 99%

“…The study involved 24 healthy, non-smoking young adults (volunteers), who were exposed to quartz diorite, rhomb porphyry, and lactose powder. Details on the exposure chamber and aerosol generation, along with the effects of the stone aggregates on lung in ammation, lung function, and blood coagulability, can be found elsewhere (Moazami et al, 2022;Nitter et al, 2022;Nitter et al, 2021). To control the exposure in the chamber, personal gravimetric samples of respirable dust and stationary gravimetric samples of total dust, thoracic dust, PM 2.5 , and respiratory dust were collected during each 4-h exposure session.…”

Section: Introductionmentioning

confidence: 99%

Comparing PM2.5, respirable dust, and total dust fractions using real-time and gravimetric samples in a human exposure chamber study

Moazami

Svendsen

Buhagen

et al. 2022

Preprint

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Using a human exposure chamber, we investigate the reliability of the DustTrak DXR monitor by comparing its results to those obtained from taking traditional gravimetric samples of two stone minerals commonly used in asphalt and lactose powder. We also discuss the possibility of using real-time monitors such as DustTrak for occupational exposure monitoring purposes. The results are based on 19 days of experiment, each day with measurements collected over 4 h. Compared to the gravimetric samples, the DustTrak overestimated the PM2.5 and respirable dust concentrations, while it underestimated the total dust concentration by a factor of nearly two. However, the ratios, being done for more than one material, between the DustTrak and the gravimetric sample readings varied daily and across the different exposure materials. Real-time sensors have the potential to excel at identifying exposure sources, evaluating the measured control efficiency, visualizing variations in exposure to motivate workers, and contributing to the identification of measures to be implemented to reduce exposure. For total dust, a correction factor of at least two should be used to bring its readings up to those for the corresponding gravimetric samples. Also, if the DustTrak is used in the initial profiling of occupational exposure, the exposure could be considered acceptable if the readings are well below the occupational exposure limit (OELs) after correction. If the DustTrak readings, after correction, is close to, or above, the accepted exposure concentrations, more thorough approaches would be required to validate the exposure.

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Association between exposure to different stone aggregates from asphalt and blood coagulability: A human exposure chamber study

Cited by 5 publications

References 51 publications

Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells

Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells

Short-term exposure to stone minerals used in asphalt affect lung function and promote pulmonary inflammation among healthy adults

Comparing PM2.5, respirable dust, and total dust fractions using real-time and gravimetric samples in a human exposure chamber study

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