Association between exposure to ambient air pollution and occurrence of inflammatory acne in the adult population

Haddad, Claudia El; Gerbaka, N.-E.; Hallit, Souheil; Tabet, C.

doi:10.1186/s12889-021-11738-0

Cited by 17 publications

(11 citation statements)

References 24 publications

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“…The involvement of pollution is not limited to an extrinsic aging factor but can reduce the quality of life [39,40]. Pollution can exacerbate certain existing inflammatory pathologies such as acne [41][42][43]. Short-term pollutant exposure has been linked to xerosis, pruritus and exacerbation of atopic dermatitis symptoms [21].…”

Section: Discussionmentioning

confidence: 99%

The impact of airborne ultrafine particulate matter on human keratinocyte stem cells

Labarrade¹,

Meyrignac²,

Plaza³

et al. 2023

Intern J of Cosmetic Sci

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Objective: Air pollution is today fully acknowledged to be a significant public health problem. Rapid urbanization exposed us to a variety of unhealthy ambient air pollutants at high concentrations. The emergence of airborne ultrafine particles has added an additional dimension to this already complex problem of air pollution. The skin has different functions, one of them being the protection against the deleterious effect of external agents. The aim of this study is to evaluate the impact of airborne ultrafine particles (UFP) pollution on skin aging and on keratinocyte differentiation. Methods: Ex vivo human skin biopsies and cultured keratinocytes stem cells (KSC) were submitted to diesel exhaust-derived UFP. Reactive oxygen species (ROS) production was assessed with the MitoSOX™ probe. Keratinocyte stemness potential was evaluated by the immunodetection of keratin 15 (K15) and p63 (∆N isoforms). Effect of UFP on the epithelial niche maintenance was evaluated by immunodetection of Sox9. Reconstructed epidermis model was used to assess the impact of UFP on keratinocyte differentiation and aging. Results: UFP exposure induced ROS production and disturbed K15, ∆Np63 and Sox9 expression in KSC or ex vivo skin. Finally, investigations on reconstructed epidermis revealed a phenotype marked by impaired keratinocyte differentiation. Conclusion: These results indicate that UFP pollution is a potent extrinsic factor of skin aging, affecting the keratinocyte stem cell potential and the skin renewal process.

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Section: Discussionmentioning

confidence: 99%

The impact of airborne ultrafine particulate matter on human keratinocyte stem cells

Labarrade¹,

Meyrignac²,

Plaza³

et al. 2023

Intern J of Cosmetic Sci

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“…However, this set was considered to be non-exhaustive, suggesting that the outcome may still be biased due to confounding. This limitation of the study has been mentioned by the authors as a possibility of "residual confounding bias" [63].…”

Section: Confounding Biasmentioning

confidence: 95%

How artificial intelligence adopts human biases: the case of cosmetic skincare industry

Georgievskaya,

Tlyachev,

Danko

et al. 2023

AI Ethics

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The cosmetic skincare industry is a growing market that extends to different regions and customer groups. In addition to scientific advances and technological developments, state-of-the-art digital approaches, including machine learning and other artificial intelligence (AI)-based techniques, are being applied at different stages of the value chain. The objectives of these efforts include optimizing the supply chain, developing high-quality, effective and safe products and personalization at every step of the customer journey. However, the use of digital technologies comes with risks and undesirable effects. These include a lack of transparency and accountability, compromised fairness and a general deficiency in data governance, all of which are critical at every customer touchpoint. This dark side of digital transformation is recognized by both businesses and governments. In this paper, we explain the concept of bias leading to unfairness for beauty technology applications. Based on published data we identified potential sources of AI bias in the cosmetic skincare industry and/or beauty tech. They were classified by the stage of the AI lifecycle: biases related to target setting, to acquisition and annotation, to modeling, to validation and evaluation, and to deployment and monitoring. We aim to create awareness of such phenomena among readers, whether executives, managers, developers or potential end-users.

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“…Outdoor air pollution could also trigger inflammation of the skin and stimulate the occurrence of inflammatory acne lesions [ 233 ]. PAH-activated AhR may further induce skin inflammation via the heightened production of pro-inflammatory cytokines from epidermal keratinocytes such as IL-1α [ 97 , 99 ] and IL-8 [ 100 ].…”

Section: Pollution-induced Skin Pathologiesmentioning

confidence: 99%

Environmental Air Pollutants Affecting Skin Functions with Systemic Implications

Bocheva

Slominski

2023

IJMS

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The increase in air pollution worldwide represents an environmental risk factor that has global implications for the health of humans worldwide. The skin of billions of people is exposed to a mixture of harmful air pollutants, which can affect its physiology and are responsible for cutaneous damage. Some polycyclic aromatic hydrocarbons are photoreactive and could be activated by ultraviolet radiation (UVR). Therefore, such UVR exposure would enhance their deleterious effects on the skin. Air pollution also affects vitamin D synthesis by reducing UVB radiation, which is essential for the production of vitamin D3, tachysterol, and lumisterol derivatives. Ambient air pollutants, photopollution, blue-light pollution, and cigarette smoke compromise cutaneous structural integrity, can interact with human skin microbiota, and trigger or exacerbate a range of skin diseases through various mechanisms. Generally, air pollution elicits an oxidative stress response on the skin that can activate the inflammatory responses. The aryl hydrocarbon receptor (AhR) can act as a sensor for small molecules such as air pollutants and plays a crucial role in responses to (photo)pollution. On the other hand, targeting AhR/Nrf2 is emerging as a novel treatment option for air pollutants that induce or exacerbate inflammatory skin diseases. Therefore, AhR with downstream regulatory pathways would represent a crucial signaling system regulating the skin phenotype in a Yin and Yang fashion defined by the chemical nature of the activating factor and the cellular and tissue context.

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Association between exposure to ambient air pollution and occurrence of inflammatory acne in the adult population

Cited by 17 publications

References 24 publications

The impact of airborne ultrafine particulate matter on human keratinocyte stem cells

The impact of airborne ultrafine particulate matter on human keratinocyte stem cells

How artificial intelligence adopts human biases: the case of cosmetic skincare industry

Environmental Air Pollutants Affecting Skin Functions with Systemic Implications

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