Association between exercise capacity and left ventricular geometry in overweight patients with mild systemic hypertension

Pierson, Lee M.; Bacon, Simon; Hinderliter, Alan L.; Babyak, Michael A.; Gullette, Elizabeth C. D.; Waugh, Robert; Blumenthal, James A.

doi:10.1016/j.amjcard.2004.07.126

Cited by 10 publications

(16 citation statements)

References 13 publications

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“…Thirdly, the inclusion of uncomplicated hypertensive patients reduces potential generalization of our results. However, common concomitant cardiovascular risk factors such as increased glucose level, obesity and older age would significantly influence the right-ventricular and right atrial mechanics, as well as functional capacity [38,39], and possibly their relationship. Namely, studies showed that the mutual effect of these factors is not additive but multiplicative [24,39], which is why we limited our study to uncomplicated hypertensive patients.…”

Section: Limitationsmentioning

confidence: 99%

“…However, common concomitant cardiovascular risk factors such as increased glucose level, obesity and older age would significantly influence the right-ventricular and right atrial mechanics, as well as functional capacity [38,39], and possibly their relationship. Namely, studies showed that the mutual effect of these factors is not additive but multiplicative [24,39], which is why we limited our study to uncomplicated hypertensive patients. However, our aim was to determine isolated influence of arterial hypertension on the relationship between functional capacity and the right heart deformation, and further studies will show how different combinations of cardiovascular risk factors impact this association.…”

Section: Limitationsmentioning

confidence: 99%

See 1 more Smart Citation

Is there a relationship between right-ventricular and right atrial mechanics and functional capacity in hypertensive patients?

Tadić

Cuspidi

Suzić-Lazić

et al. 2014

Journal of Hypertension

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Section: Limitationsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Is there a relationship between right-ventricular and right atrial mechanics and functional capacity in hypertensive patients?

Tadić

Cuspidi

Suzić-Lazić

et al. 2014

Journal of Hypertension

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“…12 Relative wall thickness (RWT) was calculated as the ratio of septal plus inferolateral wall thickness at end diastole/LV end-diastolic diameter. 13 Increased RWT was defined as Ն0.45, and increased LV mass index was defined as Ͼ81 g/m 2 for men and Ͼ62 g/m 2 for women. 14 Patients were classified into 4 groups according to RWT and LV mass index as follows 15 : normal geometry (normal LV mass, normal RWT), concentric remodeling (normal LV mass, increased RWT), concentric hypertrophy (increased LV mass, increased RWT), and eccentric hypertrophy (increased LV mass, normal RWT).…”

Section: Image Analysismentioning

confidence: 99%

Influence of Left Ventricular Hypertrophy and Geometry on Diagnostic Accuracy of Wall Motion and Perfusion Magnetic Resonance During Dobutamine Stress

Gebker

Mirelis

Jahnke

et al. 2010

Circ: Cardiovascular Imaging

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Background-The purpose of this study was to determine the influence of left ventricular (LV) hypertrophy and geometry on the diagnostic accuracy of wall motion and additional perfusion imaging during high-dose dobutamine/atropine stress magnetic resonance for the detection of coronary artery disease. Methods and Results-Combined dobutamine stress magnetic resonance (DSMR)-wall motion and DSMR-perfusion imaging was performed in a single session in 187 patients scheduled for invasive coronary angiography. Patients were classified into 4 categories on the basis of LV mass (normal, Յ81 g/m 2 in men and Յ62 g/m 2 in women) and relative wall thickness (RWT) (normal, Ͻ0.45) as follows: normal geometry (normal mass, normal RWT), concentric remodeling (normal mass, increased RWT), concentric hypertrophy (increased mass, increased RWT), and eccentric hypertrophy (increased mass, normal RWT). Wall motion and perfusion images were interpreted sequentially, with observers blinded to other data. Significant coronary artery disease was defined as Ն70% stenosis. In patients with increased LV concentricity (defined by an RWT Ն0.45), sensitivity and accuracy of DSMR-wall motion were significantly reduced (63% and 73%, respectively; PϽ0.05) compared with patients without increased LV concentricity (90% and 88%, respectively; PϽ0.05). Although accuracy of DSMR-perfusion was higher than that of DSMR-wall motion in patients with concentric hypertrophy (82% versus 71%; PϽ0.05), accuracy of DSMR-wall motion was superior to DSMR-perfusion (90% versus 85%; PϽ0.05) in patients with eccentric hypertrophy. Conclusions-The accuracy of DSMR-wall motion is influenced by LV geometry. In patients with concentric remodeling and concentric hypertrophy, additional first-pass perfusion imaging during high-dose dobutamine stress improves the diagnostic accuracy for the detection of coronary artery disease. (Circ Cardiovasc Imaging. 2010;3:507-514.)

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“…(47,48) Concentric LVH is an independent risk factor for cardiovascular complications and morbidity in essential hypertension (49)(50)(51) and it is associated with impaired exercise performance in hypertensive patients. (19) After HTx, adverse left ventricle remodeling at 1year has been shown to be associated with subsequent development of cardiac allograft vasculopathy and mortality.…”

Section: Discussionmentioning

confidence: 99%

13 Cardiac Allograft Hypertrophy Is Associated with Impaired Exercise Tolerance after Heart Transplantation

Raichlin

Al‐Omari

Kushwaha

et al. 2011

The Journal of Heart and Lung Transplantation

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Association between exercise capacity and left ventricular geometry in overweight patients with mild systemic hypertension

Cited by 10 publications

References 13 publications

Is there a relationship between right-ventricular and right atrial mechanics and functional capacity in hypertensive patients?

Is there a relationship between right-ventricular and right atrial mechanics and functional capacity in hypertensive patients?

Influence of Left Ventricular Hypertrophy and Geometry on Diagnostic Accuracy of Wall Motion and Perfusion Magnetic Resonance During Dobutamine Stress

13 Cardiac Allograft Hypertrophy Is Associated with Impaired Exercise Tolerance after Heart Transplantation

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