Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study
Zoltan Apa,
Jessica Gilsoul,
Vinciane Dideberg
et al.
Abstract:Background and objectives
Genetic variability in the dopaminergic system could contribute to age-related impairments in executive control. In this study, we examined whether genetic polymorphism for catechol-O-methyltransferase (COMT Val158Met) is related to performance on updating, shifting and inhibition tasks.
Methods
We administered a battery of executive tasks assessing updating, shifting and inhibition functions to 45 older and 55 younger healthy participants, and created composite z-scores associated … Show more
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