Association between etiologic factors in infertile couples and fertilization failure in conventional in vitro fertilization cycles

Zhu, Jun; Jiang, Hong; Rb, He; Hq, Yin; Cl, Wang; Y, Li; Du, Xiuli

doi:10.1111/andr.12048

Cited by 16 publications

(11 citation statements)

References 37 publications

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“…Therefore, early cumulus cell removal was applied for patients with a higher risk of fertilization failure to avoid the excessive use of ICSI technique in clinical practice. Previous studies suggested that primary infertility and longer infertility duration were important risk factors for total fertilization failure (31,32). The incidence of total fertilization failure was also higher in patients with unexplained infertility (33,34).…”

Section: Discussionmentioning

confidence: 92%

Effects of Early Cumulus Cell Removal on Treatment Outcomes in Patients Undergoing In Vitro Fertilization: A Retrospective Cohort Study

et al. 2021

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BackgroundEarly cumulus cell removal combined with early rescue intracytoplasmic sperm injection (ICSI) has been widely practiced in many in vitro fertilization (IVF) centers in China in order to avoid total fertilization failure. However, uncertainty remains whether the pregnancy and neonatal outcomes are associated with early cumulus cell removal.ObjectivesTo investigate if early cumulus cell removal alone after 4 hours co-incubation of gametes (4 h group), has detrimental effect on the pregnancy and neonatal outcomes in patients undergoing IVF, through a comparison with conventional cumulus cell removal after 20 hours of insemination (20 h group).MethodsThis retrospective cohort study included 1784 patients who underwent their first fresh cleavage stage embryo transfer at the Centre for Assisted Reproduction of Shanghai First Maternity and Infant Hospital from June 2016 to December 2018 (4 h group, n=570; 20 h group, n=1214). A logistic regression analysis was performed to examine the independent association between early cumulus cell removal and pregnancy outcomes after adjustment for potential confounders. The neonatal outcomes between the two groups were compared.ResultsWhen compared with the 20 h group, the 4 h group had similar pregnancy outcomes, including rates for biochemical pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, ectopic pregnancy, multiple pregnancy, live birth. There were 1073 infants delivered after embryo transfer (4 h group, n=337; 20 h group, n=736). Outcomes in both groups were similar for both singleton and twin gestations, including preterm birth rate and very preterm birth rate, mean birth weight, mean gestational age, sex ratio at birth and rate of congenital birth defects. In addition, findings pertaining to singleton gestations were also similar in the two groups for Z-scores (gestational age- and sex-adjusted birth weight), rates of small for gestational age, very small for gestational age, large for gestational age and very large for gestational age infants.ConclusionsIn this study early cumulus cell removal alone was not associated with adverse pregnancy and neonatal outcomes. From this perspective, early cumulus cell removal to assess for a potential early rescue ICSI is therefore considered to be a safe option in patients undergoing IVF.

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Section: Discussionmentioning

confidence: 92%

Effects of Early Cumulus Cell Removal on Treatment Outcomes in Patients Undergoing In Vitro Fertilization: A Retrospective Cohort Study

et al. 2021

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“…The total fertilisation failure (TFF) refers to fertilisation failure in all oocytes. Patients with primary infertility and oligoasthenozoospermia might be at a higher risk of fertilisation failure [1]. A recent study showed that impaired sperm parameters were mainly involved in complete fertilisation failure in IVF and lower oocyte quality in intracytoplasmic sperm injection (ICSI) [2].…”

Section: Introductionmentioning

confidence: 99%

Correlation between sperm mitochondrial ND5 and ND6 gene variations and total fertilisation failure

Mao

Huang

Geng

et al. 2020

aoms

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Introduction: The purpose of this study was to investigate the correlation between sperm mitochondrial NADH dehydrogenase subunit 5 (ND5) and NADH dehydrogenase subunit 6 (ND6) gene variations and total fertilisation failure (TFF). Material and methods: A total of 232 sperm samples at the fresh in vitro fertilisation (IVF) cycle or the half-intracytoplasmic sperm injection (ICSI) cycle were collected for this retrospective controlled study on Han Chinese people between July 2011 and April 2014. Of the 232 total samples, 45 were from the IVF-TFF group and 187 were from couples with normal fertilisation (fertilisation rate > 50%). The mitochondrial ND5 and ND6 gene variations and sperm haplotypes were confirmed using nested PCR and DNA sequencing. Results: Ten homozygous variations were newly discovered, namely C12417T,

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“…Therefore, early cumulus cell removal was applied for patients with a higher risk of fertilization failure to avoid the excessive use of ICSI technique in clinical practice. Previous studies suggested that primary infertility and longer infertility duration were important risk factors for total fertilization failure [29,30]. The incidence of total fertilization failure was also higher in patients with unexplained infertility [31,32].…”

Section: Discussionmentioning

confidence: 92%

Effects of Early Cumulus Cell Removal on the Treatment Outcomes in Patients Undergoing in Vitro Fertilization: A Retrospective Cohort Study

Kong

Yin²,

Tang

et al. 2021

Preprint

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Background: Early cumulus cell removal combined with early rescue intracytoplasmic sperm injection (ICSI) has been widely practiced in many in vitro fertilization (IVF) centers in China in order to avoid total fertilization failure. This study aimed to investigate the effects of early cumulus cell removal alone after 4 h co-incubation of gametes (4 h group) on the pregnancy and neonatal outcomes as compared with the conventional cumulus cell removal after 20 h of insemination (20 h group) in patients undergoing IVF. Methods: This retrospective cohort study included 1784 patients who underwent their first fresh cleavage embryo transfer at the Centre for Assisted Reproduction of Shanghai First Maternity and Infant Hospital from June 2016 to December 2018 (4 h group, n=570; 20 h group, n=1214). There were 1073 infants delivered after the embryo transfer (4 h group, n=337; 20 h group, n=736). A logistic regression analysis was performed to examine the independent association between early cumulus cell removal and pregnancy outcomes after adjustment for the potential confounders. The neonatal outcomes between the two groups were compared.Result(s): The 4 h group had similar pregnancy outcomes, including biochemical pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, miscarriage rate, ectopic pregnancy rate, multiple pregnancy rate, live birth rate, when compared with the 20 h group. Both groups had comparable singleton and twin delivery rates (32.9% versus 33.5% and 13.2% versus 13.9%, respectively). There were 1073 infants delivered after the embryo transfer (4 h group, n=337; 20 h group, n=736). In both singleton and twin gestations, the preterm birth rate and very preterm birth rate, mean birth weight, mean gestational age, sex ratio at birth and rate of congenital birth defects in the 4 h group were similar to those in the 20 h group. In addition, Z-scores (gestational age- and sex-adjusted birthweight), the rates of small for gestational age, very small for gestational age, large for gestational age and very large for gestational age infants were also similar between the two groups in singleton gestations.Conclusion(s): Early cumulus cell removal alone was not associated with adverse pregnancy and neonatal outcomes in patients undergoing IVF. Thus, early cumulus cell removal to assess for a potential early rescue ICSI seems to be safe in terms of pregnancy and live birth outcomes.

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Association between etiologic factors in infertile couples and fertilization failure in conventional in vitro fertilization cycles

Cited by 16 publications

References 37 publications

Effects of Early Cumulus Cell Removal on Treatment Outcomes in Patients Undergoing In Vitro Fertilization: A Retrospective Cohort Study

Effects of Early Cumulus Cell Removal on Treatment Outcomes in Patients Undergoing In Vitro Fertilization: A Retrospective Cohort Study

Correlation between sperm mitochondrial ND5 and ND6 gene variations and total fertilisation failure

Effects of Early Cumulus Cell Removal on the Treatment Outcomes in Patients Undergoing in Vitro Fertilization: A Retrospective Cohort Study

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