Association between epidermal growth factor receptor mutation status, clinicopathological characteristics and TTF-1 expression in lung adenocarcinoma: A single center study

Abstract

Introduction/Objective. The presence of EGFR mutations is the best predictor of response for therapy with tyrosine kinase inhibitors. In this study we investigate association between EGFR mutations and clinicopathological characteristics and thyroid transcription factor (TTF-1) expression in lung adenocarcinomas (ADs). Methods. We analyzed 142 surgical samples from patients with histologically confirmed lung ADs from January, 2010. to December, 2015. All tumor tissues were reclassified according to WHO criteria and EGFR mutations detected by Real time PCR. TTF-1 expression was detected by immunohistochemistry in 83 out of 142 cases. The association between EGFR and TTF-1 expression was analyzed using ?2 test or Fisher?s exact test with SPSS software version 20.0. Results. This study included 78 male and 64 women with a median age 61.6 (range, 42-82) years. Acinar (ACN) and solid (SOL) were the most common histological types (47.9% and 38.7% respectively). TTF-1 expression was present in 69 of 83 (83%) ADs. The EGFR mutation was found in 7%, more frequently in women, and patients with smoking history, and acinar type of ADs, whereas it had no association with age and pathological stage and TTF-1 expression. Conclusion. In conclusion, the results of this study demonstrate that the presence of EGFR mutations is associated with some clinical characteristics and histologic type of ADs, but not with TTF-1 expression.