Association between epidemic dynamics of Covid-19 infection and ABO blood group types

Abstract

Background: Covid-19 pandemic is the most critical challenge nowadays for the manhood, and the infection and death cases are still speedily increasing. Since there are no available vaccine and specifically effective treatment, to break the infectious way of the pandemic remains the unique measure to efficiently combat Covid-19 infection. Understanding factors that affect the Covid-19 infection can help make better balance between activity restriction and infection dynamics. This study sought to investigate association between Covid-19 infection and blood type distribution. Methods: The big data provided by World Health Organization and Johns Hopkins University were taken to assess epidemic dynamics of Covid-19 infection. Growth rate and doubling time of infection and death cases, reproductive number, infection and death cases in the mid-exponential phase were analyzed in relation to blood type distribution. Results: Growth rate of infection and death cases correlated significantly to blood type A proportion of the population positively while to blood type B proportion negatively. In comparison with lower blood type A population (< 30%) people with higher blood type A (≥ 30%) had more infection and death cases in the early exponential phase, higher growth rates, and shorter case doubling time for infection and death. Discussion: Covid-19 infection is significantly associated with blood type distribution and people with blood type A are more susceptible to Covid-19 infection and have higher epidemic dynamics and higher case fatality rate. The results of this study provide important and useful information for fighting Covid-19 pandemic.

Value of Chest Computed Tomography in Diagnosis of COVID-19 Related Pneumonia and Its Severity in Relation to ABO Blood Grouping System

“…As regard Rh system, there were 21 Rh positive patients (35%) and 39 Rh negative patients (65%) in all studied patients. This agrees with studies by Liu et al (13) , Bhandari et al (14) and Golinelli et al (15) , studies demonstrate a correlation between COVID-19 susceptibilities and ABO blood grouping, with group A being more susceptible. More research is necessary to determine how to implement these relationships in clinical practice.…”

Modelling suggests blood group incompatibility may substantially reduce SARS-CoV-2 transmission

“…Similarly, communities with a highly skewed A:B ratio will have a higher R steady and a shorter doubling time than communities with more nearly equal numbers of A and B individuals. This latter prediction has already been supported by two recent preprints [29, 30]…”

ABO Blood Types and COVID-19: Spurious, Anecdotal, or Truly Important Relationships? A Reasoned Review of Available Data

“…Thus, ORs for blood group O ranged from 0.53 to 0.9 and ORs for non-O blood groups ranged from 1.12 to 3.7. Meta-analyses of the earliest available data have already been conducted, confirming the effect [ 88 , 89 , 90 , 91 , 92 ].…”