Association between engulfment and cell motility 1-gene polymorphisms and diabetic nephropathy in an Egyptian population with type 2 diabetes

Nahid, Maggie S. El; Al-Ganiny, Amal Fouad Mohamed; Yousef, Rasha Nazih

doi:10.1007/s40200-022-00990-9

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…This systematic review finally included 17 studies, of which 15 studies were eligible and included in meta-analysis and the other two studies were excluded due to lack of data (Fig 1). Twelve studies followed a case-control design [4,11,[25][26][27][28][29][30][31][32][33][34] while the other 5 were genomewide association studies [7,[35][36][37][38], with a total of 5794 DM with DKD patients, 4886 DM without DKD patients, and 2023 healthy controls to assess the impact of ELMO1 polymorphism on DKD susceptibility. Most studies included patients with T2DM, except for two studies with T1DM patients [7,36].…”

Section: Study Characteristics and Demographymentioning

confidence: 99%

“…Studies were sub-grouped based on their geographical region; Middle East [25,28,29,32,37], South Asia [26,31,33,35], East Asia [4,11,30,33,38], Europe [34], and USA [7,27,36].…”

Section: Study Characteristics and Demographymentioning

confidence: 99%

“…Hou 2019 [38], Bodhini 2016 [35], and Wu 2013 [30] Risk of bias and publication bias. Higher risk of bias is associated with NOS of 6 or less, as one study in our review received 6 [37] account of lacking quality in the selection section. Lower risk of bias is achieved once studies reach the score 7 or better, which most studies did with the mean NOS of 8.23±1.01 (Fig 6).…”

Section: Study Characteristics and Demographymentioning

confidence: 99%

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Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis

Azarboo,

Hosseinkhani,

Ghaseminejad-Raeini

et al. 2024

PLoS ONE

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Background Previous research has suggested that the ELMO1 gene may play a role in the development of diabetic kidney disease. Diabetic kidney disease (DKD) is a serious complication of diabetes and the leading cause of chronic kidney disease and end-stage renal disease (ESRD). Objective and rationale This study aim was to systematically review and explore the association between ELMO1 gene polymorphisms and diabetic kidney disease. A comprehensive systematic review provides a clear conclusion and high-level evidence for the association between ELMO1 gene and DKD for future application in personalized medicine. Methods A comprehensive search of electronic databases, per PRISMA instructions, was conducted in Scopus, EMBASE, Web of Science, and PubMed databases from 1980 to January 2023. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using appropriate models. Subgroup and sensitivity analyses were performed to explore potential sources of heterogeneity and assess the robustness of the findings. Results A total of 5794 diabetes patients with DKD, 4886 diabetes patients without DKD, and 2023 healthy controls were included in the 17 studies that made up this systematic review. In the investigation of DM (Diabetes Mellitus) with DKD vs. DM without DKD, the susceptibility for DKD for the EMLO1 rs741301 polymorphism indicated a significant difference under the dominant, homozygote, and recessive genetic models. The susceptibility for DKD for the EMLO1 rs1345365, rs10255208, and rs7782979 polymorphisms demonstrated a significant difference under the allele genetic models in the analysis of DM with DKD vs. DM without DKD groups. There was a considerable increase in DKD risk in the Middle East when the population was stratified by the region. Conclusion The findings of the meta-analysis show that there are a significant connection between the EMLO1 rs741301 polymorphism and DKD susceptibility in overall analyses; as well as rs1345365, rs10255208, and rs7782979 polymorphisms; especially in the Middle East region.

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Section: Study Characteristics and Demographymentioning

confidence: 99%

“…Studies were sub-grouped based on their geographical region; Middle East [25,28,29,32,37], South Asia [26,31,33,35], East Asia [4,11,30,33,38], Europe [34], and USA [7,27,36].…”

Section: Study Characteristics and Demographymentioning

confidence: 99%

Section: Study Characteristics and Demographymentioning

confidence: 99%

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Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis

Azarboo,

Hosseinkhani,

Ghaseminejad-Raeini

et al. 2024

PLoS ONE

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The Potential Impact of MYH9 (rs3752462) and ELMO1 (rs741301) Genetic Variants on the Risk of Nephrotic Syndrome Incidence

Hassan,

Elsaid,

Abou -Elzahab

et al. 2023

Biochem Genet

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The kidney lost a lot of protein in the urine when you have nephrotic syndrome (NS). Clinical manifestations mostly common in NS include massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Idiopathic nephrotic syndrome is currently classi ed into steroid-sensitive (SSNS) and steroid-resistant (SRNS) based on the initial response to corticosteroid therapy at presentation. Several reports examined the association of the MYH9 gene (rs3752462, C >T) variant and ELMO1 (rs741301 G >A) variant as risk factors for Nephrotic Syndrome. This study aimed to determine the potential effect of the MYH9 gene (rs375246, C >T) and ELMO1 (rs741301) variant on the risk of (NS) among Egyptian Children. This study included two hundred participants involving 100 NS cases and 100 healthy controls free from NS. The MYH9 gene (rs3752462, C >T) variant and ELMO1 (rs G>A741301) variant were analyzed by ARMS-PCR technique. Nephrotic syndrome cases include 74% SRNS and 26% SDNS. Higher frequencies of the heterozygous carrier (CT) and homozygous variant (TT) genotypes of the MYH9 (rs375246, C >T) variant were observed in NS patients compared to the controls with p-value < 0.001.The frequencies of the MYH9 (rs375246, C >T variant indicated a statistically signi cant elevated risk of NS under various genetic models, including allelic model (OR=2.85, p<0.001), dominant (OR =3.97, P < 0.001) models and the recessive model OR = 5.94, p< 0.001). Higher frequencies of the heterozygous carrier (GA) and homozygous variant (AA) genotypes of ELMO1 (rs G>A741301) variant were observed in NS patients compared to the controls with p-value <0.001. The frequencies of the ELMO1 (rs G>A741301) variant indicated a statistically signi cant elevated risk of NS under various genetic models, including allelic model (OR=2.15, p<0.001), dominant models (OR=2.8, p<0.001) and the recessive model (OR = 4.17, p=0.001). Both MYH9 and ELMO1variants are signi cantly different in NS in comparison with the control group (p<0.001).The MYH9 gene (rs375246, C >T) and ELMO1 (rs G>A741301) variants were considered independent risk factors for NS among Egyptian Children.

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Association between engulfment and cell motility 1-gene polymorphisms and diabetic nephropathy in an Egyptian population with type 2 diabetes

Cited by 2 publications

References 20 publications

Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis

Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis

The Potential Impact of MYH9 (rs3752462) and ELMO1 (rs741301) Genetic Variants on the Risk of Nephrotic Syndrome Incidence

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