Association Between Endothelial Nitric Oxide Synthase (eNOS) −786 T/C and 27-bp VNTR 4b/a Polymorphisms and Preeclampsia Development

Jakovljević, Tamara; Kontić-Vučinić, Olivera; Nikolic, Nadja; Čarkić, Jelena; Stamenkovic, Jelena; Soldatović, Ivan; Milašin, Jelena

doi:10.1007/s43032-021-00632-0

Cited by 12 publications

(5 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(2021) с участием 100 пациенток в Сербии (50 беременных с ПЭ, 50 -с неосложненной беременностью) показало, что полиморфизм rs2070744 значимо чаще встречался у пациенток с ПЭ (р < 0,05). Однако его наличие не могло служить средством прогнозирования ни тяжести ПЭ, ни времени начала заболевания [28].…”

Section: кодируемое вещество материнские полиморфизмыunclassified

“…[29] продемонстрировали связь между rs2070744 и наиболее опасными формами ПЭ -HELLP-синдромом и эклампсией. Ранее ассоциации между полиморфизмом NOS3 T-786C и ПЭ описаны у представительниц кавказской, азиатской и американской популяций [28]. Метаанализ 11 работ, опубликованный в 2013 году B. Dai и соавт., также подтвердил наличие данной взаимосвязи [30].…”

Section: кодируемое вещество материнские полиморфизмыunclassified

“…Jakovljevic и соавт. (2021), проведенное у сербских женщин, не подтвердило наличие связи между полиморфизмом rs1799983 и ПЭ в данной популяции [28].…”

Section: кодируемое вещество материнские полиморфизмыunclassified

“…Jakovljevic и соавт. (2021) продемонстрировало намного более высокую частоту гомозиготного варианта VNTR (4b/a) в группе беременных с ПЭ, чем в группе контроля (р < 0,05), что объяснялось почти 8-кратным увеличением риска ее развития у носительниц rs61722009 [28].…”

Section: № 3 (58) 2023unclassified

See 3 more Smart Citations

The role of polymorphisms of blood pressure regulator genes in the pathogenesisof preeclampsia

Ganeeva,

Gabidullina,

Kapelyushnik

et al. 2023

WHAR

View full text Add to dashboard Cite

Aim: To analyze the information presented in scientific publications on the role of polymorphic variants of genes responsible for the regulation of blood pressure (BP) in the pathogenesis of preeclampsia (PE). Key points. Genome-wide association studies conducted for PE confirms the multifactorial nature of its pathogenesis and demonstrates a number of BP regulator genes, polymorphic variants of which are associated with its development. A review of the literature showed that PE and diseases of the cardiovascular system have similar mechanisms of inheritance. Conclusion. The use of molecular genetic markers of PE opens up new opportunities for personalized prediction of this gestational complication and increase the effectiveness of preventive measures. Keywords: preeclampsia, blood pressure regulation genes, genetic polymorphisms, prognosis.

show abstract

Section: кодируемое вещество материнские полиморфизмыunclassified

Section: № 3 (58) 2023unclassified

See 2 more Smart Citations

The role of polymorphisms of blood pressure regulator genes in the pathogenesisof preeclampsia

Ganeeva,

Gabidullina,

Kapelyushnik

et al. 2023

WHAR

View full text Add to dashboard Cite

show abstract

“…In PE and FGR pregnancies, excessive production of sFlt-1 leads to the binding of VEGF and thus to the lack of appropriate eNOS activity [ 101 ]. Jakovljevic et al revealed that -786 T/C and VNTR 4b/a eNOS gene polymorphisms were associated with PE risk [ 102 ]. A recently published meta-analysis confirmed that the c.894 T (p.298Asp) and g.-786C alleles of eNOS gene may influence the NO bioavailability and were significantly associated with PE [ 103 ].…”

Section: Fetal Growth Restriction and Preeclampsia As A Maternal Factormentioning

confidence: 99%

Genetic Background of Fetal Growth Restriction

Nowakowska¹,

Pankiewicz²,

Nowacka³

et al. 2021

IJMS

View full text Add to dashboard Cite

Fetal growth restriction (FGR) is one of the most formidable challenges in present-day antenatal care. Pathological fetal growth is a well-known factor of not only in utero demise in the third trimester, but also postnatal morbidity and unfavorable developmental outcomes, including long-term sequalae such as metabolic diseases, diabetic mellitus or hypertension. In this review, the authors present the current state of knowledge about the genetic disturbances responsible for FGR diagnosis, divided into fetal, placental and maternal causes (including preeclampsia), as well as their impact on prenatal diagnostics, with particular attention on chromosomal microarray (CMA) and noninvasive prenatal testing technique (NIPT).

show abstract

The eNOS-G894T genetic polymorphism and risk of preeclampsia: A case-control study, an updated meta-analysis, and a bioinformatic assay

Karimian,

Yaqubi,

Karimian

2023

Cytokine

View full text Add to dashboard Cite

Association Between Endothelial Nitric Oxide Synthase (eNOS) −786 T/C and 27-bp VNTR 4b/a Polymorphisms and Preeclampsia Development

Cited by 12 publications

References 84 publications

The role of polymorphisms of blood pressure regulator genes in the pathogenesisof preeclampsia

The role of polymorphisms of blood pressure regulator genes in the pathogenesisof preeclampsia

Genetic Background of Fetal Growth Restriction

The eNOS-G894T genetic polymorphism and risk of preeclampsia: A case-control study, an updated meta-analysis, and a bioinformatic assay

Contact Info

Product

Resources

About