Abstract:Patients with celiac disease can have a low rate of protective hepatitis B (HBV) antibody titers after vaccination. We aimed to evaluate the HBV seroconversion in celiac disease (CD) children at the time of diagnosis as well as to identify the presence of possible predictive factors. Celiac disease children were prospectively enrolled and tested for antibodies against the S protein of HBV (HBsAg) at time of diagnosis between January 2009 and February 2020. Based on the serologic response to the vaccine, “respo… Show more
“…-Tanwar y colaboradores (23) 2020 India Pacientes con EC e hipertensión portal 42 2 4,8% contra el VHB se ha demostrado previamente (34) . Trovato y colaboradores (40) evaluó a 96 niños con EC, el 41,7% (n = 40) mostró títulos de anticuerpos no protectores o ausentes contra el VHB. Los valores elevados de tTG-IgA (p=0,023) y una mayor edad en el momento del diagnóstico (p <0,001) se asociaron con una ausencia de seroconversión a la vacuna contra el VHB.…”
Some theories suggest that the development of the immune response to clear hepatitis B triggers the intestinal tissue damage seen in celiac disease in genetically predisposed individuals. Although the role of hepatitis B virus infection in the development of autoimmune diseases has been widely discussed in the literature, it remains a controversial topic. Our objective is to review whether there is an association between hepatitis B and celiac disease and the particularities of vaccination against hepatitis B in celiac patients.
“…-Tanwar y colaboradores (23) 2020 India Pacientes con EC e hipertensión portal 42 2 4,8% contra el VHB se ha demostrado previamente (34) . Trovato y colaboradores (40) evaluó a 96 niños con EC, el 41,7% (n = 40) mostró títulos de anticuerpos no protectores o ausentes contra el VHB. Los valores elevados de tTG-IgA (p=0,023) y una mayor edad en el momento del diagnóstico (p <0,001) se asociaron con una ausencia de seroconversión a la vacuna contra el VHB.…”
Some theories suggest that the development of the immune response to clear hepatitis B triggers the intestinal tissue damage seen in celiac disease in genetically predisposed individuals. Although the role of hepatitis B virus infection in the development of autoimmune diseases has been widely discussed in the literature, it remains a controversial topic. Our objective is to review whether there is an association between hepatitis B and celiac disease and the particularities of vaccination against hepatitis B in celiac patients.
Hepatitis B virus (HBV) infection remains a significant global health concern worldwide, contributing to high rates of mortality and morbidity, including chronic hepatitis B, cirrhosis, and hepatocellular carcinoma (HCC). Universal vaccination programs have significantly reduced the rate of HBV transmission; however, a subset of individuals fail to develop a protective immune response following vaccination and are termed nonresponders. A comprehensive search strategy using the PubMed, Google Scholar, and Web of Science databases was employed to search for relevant studies using keywords including “hepatitis B vaccine”, “vaccine nonresponse”, “immunogenicity”, “immune response to the hepatitis B vaccine”, and “associated risk factors”. Factors influencing the vaccine’s response include demographic factors, such as age and sex, with increased nonresponse rates being observed in older adults and males. Obesity, smoking, and alcohol consumption are lifestyle factors that decrease the vaccine response. Medical conditions, including diabetes, chronic kidney and liver diseases, HIV, celiac disease, and inflammatory bowel disease, affect the vaccine response. Major histocompatibility complex (MHC) haplotypes and genetic polymorphisms linked to immune regulation are genetic factors that further influence the vaccine’s effectiveness. To reduce the global burden of hepatitis B infection, it is essential to understand these factors to improve vaccine effectiveness and develop individualized vaccination strategies.
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