Association between eczema and risk of depression: A systematic review and meta-analysis of 188,495 participants

Bao, Qinyi; Chen, Lina; Lu, Zhiyu; Ma, Yunxiang; Guo, Lili; Zhang, Shuaishuai; Huang, Xiaoping; Xu, Suling; Ruan, Lifang

doi:10.1016/j.jad.2018.05.007

Cited by 23 publications

(35 citation statements)

References 33 publications

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“…In contrast, risk estimates for “probable” emotional disorder in the sensitivity analysis were similar to risk estimates for “possible/probable” emotional disorder. A recent meta‐analysis (n = 188 495) showed that AD among adults and adolescents is associated with increased risk for depression (pooled RR: 2.02; 95% CI: 1.76‐2.31) . Our study indicates that emotional problems among individuals with AD and asthma start already in childhood.…”

Section: Discussionmentioning

confidence: 52%

“…A recent meta-analysis (n = 188 495) showed that AD among adults and adolescents is associated with increased risk for depression (pooled RR: 2.02; 95% CI: 1.76-2.31). 45 Our study indicates that emotional problems among individuals with AD and asthma start already in childhood. We found positive associations of concurrently assessed AD and asthma symptoms during the past year with emotional problems at 6.5 years, with the highest odds of emotional problems observed in children with persistent AD symptoms in the previous year, probably representing more severe disease.…”

Section: Discussionmentioning

confidence: 60%

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Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Ballardini

Kramer

Oken

et al. 2019

Clin Experimental Allergy

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Background Conflicting findings from studies evaluating associations of allergic disease with child behaviour require longitudinal studies to resolve. Objective To estimate the magnitude of associations of atopic dermatitis (AD) in infancy, and symptoms of asthma and AD at 6.5 years, with child behaviour at 6.5 years. Methods Secondary cohort analysis of the Promotion of Breastfeeding Intervention Trial (PROBIT). PROBIT enrolled 17 046 infants at birth and followed them up at 6.5 years (n = 13 889). Study paediatricians collected data on infantile AD at repeated follow‐up examinations during the first year of life. At 6.5 years, paediatricians performed skin prick tests and parents reported asthma and AD symptoms during the prior year. In addition, parents and teachers completed the Strength and Difficulties Questionnaire, which includes scales on hyperactivity/inattention, emotional problems, conduct problems, peer problems and prosocial behaviours. Results Physician‐diagnosed AD in the first year of life was not associated with increased risk for behavioural problems at 6.5 years. Emotional problems at 6.5 years were more common among children with AD symptoms (OR: 2.24, 95% CI: 1.62‐3.12) and asthma symptoms (OR: 1.45; 95% CI: 1.07‐1.96) during the past year at 6.5 years and ORs for children with symptoms of more severe AD and asthma were also higher. AD in the past year was also associated with probable hyperactivity/inattention disorder at 6.5 years (OR: 2.05; 95% CI: 1.09‐3.84). Other subscales of the SDQ were not related to asthma or AD symptoms during the past year. Conclusions and clinical relevance Children with AD symptoms were at higher risk for concomitant hyperactivity/inattention and emotional disorder, and children with asthma symptoms were at higher risk of having concomitant emotional problems. However, AD during infancy did not predict childhood behaviours.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 60%

Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Ballardini

Kramer

Oken

et al. 2019

Clin Experimental Allergy

View full text Add to dashboard Cite

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“… 4 The most common psychological symptoms observed in dermatologic patients are depression and anxiety. 5 , 6 Except symptoms and disfigurement, the underlying mechanisms of inflammatory skin diseases, such as changes in cytokine levels, cardiometabolic profiles, and microbiome diversity, may also be involved in the development of sleep and mental disorders. 7 , 8 , 9 Patient-reported outcomes, widely used as the end points in clinical and epidemiologic studies, capture the effects of diseases or interventions from the patient's perspective.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and patient-reported outcomes of noncommunicable skin diseases among college students in China

Shen

Xiao

et al. 2020

JAAD International

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Background: The prevalence and health-related quality of life of skin disease have been understudied in adolescents. Objective: To investigate the prevalence and relevant patient-reported outcomes of noncommunicable skin diseases in college students. Methods: First-year college students from 5 universities in China were investigated in the cross-sectional study. Skin diseases were diagnosed by dermatologists in the field survey. Itch and pain, symptoms of depression and anxiety, and sleep quality were measured by validated tools. Results: A total of 28,364 students consented to participate and completed the survey. The prevalence of acne, eczema, chronic urticaria, psoriasis, and vitiligo was 10.3%, 5.8%, 2.6%, 0.16%, and 0.23%, respectively. Eczema and chronic urticaria were associated with lower health utility estimates. Most diseases, but not psoriasis and vitiligo, were associated with the symptoms of depression and sleep disturbance. Itch intensity predicted other patient-reported outcome scores better in healthy controls than in individuals with skin diseases. Sex difference in the associations of skin diseases with patient-reported outcomes was not identified. Limitations: Cross-sectional study design and limited generalizability to the nonstudent population. Conclusion: Skin diseases are associated with moderately impaired emotional well-being, sleep quality, and quality of life, partly attributable to cutaneous symptoms.

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“…Previous systematic reviews have aimed to establish summary measure of effects for the association between either atopic eczema or psoriasis and specific mental illnesses (eg, depression); the majority have focused on the relationship between atopic eczema or psoriasis and CMDs. [15][16][17][18][19] One systematic review has investigated the risk factors that mediate the association between atopic eczema and mental illness in children and adolescents only. The majority of studies in this review of children were conducted in European countries or territories.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for mental illness in adults with atopic eczema or psoriasis: protocol for a systematic review

et al. 2020

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IntroductionEvidence indicates that people with the common inflammatory skin diseases atopic eczema or psoriasis are at increased risk of mental illness. However, the reasons for the relationship between skin disease and common mental disorders (ie, depression and anxiety) or severe mental illnesses (ie, schizophrenia, bipolar disorder and other psychoses) are unclear. Therefore, we aim to synthesise the available evidence regarding the risk factors for mental illness in adults with atopic eczema or psoriasis.Methods and analysisWe will conduct a systematic review of randomised controlled trials, cohort, case–control and cross-sectional studies. We will search the following databases from inception to March 2020: Medline, Embase, Global Health, Scopus, the Cochrane Library, Web of Science, Base, PsycInfo, the Global Resource of Eczema Trials, and the grey literature databases Open Grey, PsycExtra and the New York Academy of Medicine Grey Literature Report. We will also search the bibliographies of eligible studies and relevant systematic reviews to identify additional relevant studies. Citation searching of large summary papers will be used to further identify relevant publications. Two reviewers will initially review study titles and abstracts for eligibility, followed by full text screening. We will extract data using a standardised data extraction form. We will assess the risk of bias of included studies using the Quality in Prognosis Studies tool. We will synthesise data narratively, and if studies are sufficiently homogenous, we will consider a meta-analysis. We will assess the quality of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation framework.Ethics and disseminationEthical approval is not required for a systematic review. Results of the review will be published in a peer-reviewed journal and disseminated through conferences.PROSPERO registration numberCRD42020163941.

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Association between eczema and risk of depression: A systematic review and meta-analysis of 188,495 participants

Cited by 23 publications

References 33 publications

Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Prevalence and patient-reported outcomes of noncommunicable skin diseases among college students in China

Risk factors for mental illness in adults with atopic eczema or psoriasis: protocol for a systematic review

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