Association between early oxidative DNA damage and iron status in women with gestational diabetes mellitus

Erbağcı, Mehmet Oğuz; Tuna, Gamze; Kose, Semir; Dal-Bekar, Nazlı Ecem; Akış, Merve; Kant, Melis; Altunyurt, Sabahattin; Islekel, Gul Huray

doi:10.1016/j.reprotox.2021.05.009

Cited by 9 publications

(7 citation statements)

References 54 publications

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“…Most of them are focused on blood glucose monitoring for the management of GDM [72][73][74], and not on the prediction of post load glycemia as an early detection or alternative screening tool for this pregnancy disorder. Furthermore, although some of them evaluate the correlation between different variables and fasting glycemia [75][76][77], postprandial glycemia [78], glucose challenge test (GCT) post load glycemia [79,80] and OGTT post load glycemia [81][82][83], they don't test their predictive performance through error metrics like RMSE and RE. To our knowledge, this is the first study that introduces and properly assesses ML models to predict OGTT post load glycemia so as to make the early detection and screening of GDM independent of the diagnostic criteria.…”

Section: Plos Onementioning

confidence: 99%

Evaluation of first and second trimester maternal thyroid profile on the prediction of gestational diabetes mellitus and post load glycemia

et al. 2023

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Maternal thyroid alterations have been widely associated with the risk of gestational diabetes mellitus (GDM). This study aims to 1) test the first and the second trimester full maternal thyroid profile on the prediction of GDM, both alone and combined with non-thyroid data; and 2) make that prediction independent of the diagnostic criteria, by evaluating the effectiveness of the different maternal variables on the prediction of oral glucose tolerance test (OGTT) post load glycemia. Pregnant women were recruited in Concepción, Chile. GDM diagnosis was performed at 24–28 weeks of pregnancy by an OGTT (n = 54 for normal glucose tolerance, n = 12 for GDM). 75 maternal thyroid and non-thyroid parameters were recorded in the first and the second trimester of pregnancy. Various combinations of variables were assessed for GDM and post load glycemia prediction through different classification and regression machine learning techniques. The best predictive models were simplified by variable selection. Every model was subjected to leave-one-out cross-validation. Our results indicate that thyroid markers are useful for the prediction of GDM and post load glycemia, especially at the second trimester of pregnancy. Thus, they could be used as an alternative screening tool for GDM, independently of the diagnostic criteria used. The final classification models predict GDM with cross-validation areas under the receiver operating characteristic curve of 0.867 (p<0.001) and 0.920 (p<0.001) in the first and the second trimester of pregnancy, respectively. The final regression models predict post load glycemia with cross-validation Spearman r correlation coefficients of 0.259 (p = 0.036) and 0.457 (p<0.001) in the first and the second trimester of pregnancy, respectively. This investigation constitutes the first attempt to test the performance of the whole maternal thyroid profile on GDM and OGTT post load glycemia prediction. Future external validation studies are needed to confirm these findings in larger cohorts and different populations.

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Section: Plos Onementioning

confidence: 99%

Evaluation of first and second trimester maternal thyroid profile on the prediction of gestational diabetes mellitus and post load glycemia

et al. 2023

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“…One hypothesis could be based on the observations that iron overload led to oxidative stress and that pancreatic beta-cells were susceptible to oxidative stress [ 137 ]. Although elevated serum and urinary levels of oxidative DNA damage products were found in GDM patients [ 138 ], direct evidence of impaired pancreatic beta-cell functions needs to be further elucidated.…”

Section: Role Of Iron Metabolism and Ferroptosis In Pathological Preg...mentioning

confidence: 99%

Iron Metabolism and Ferroptosis in Physiological and Pathological Pregnancy

Zhang

Jin

2022

IJMS

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Iron is a vital element in nearly every living organism. During pregnancy, optimal iron concentration is essential for both maternal health and fetal development. As the barrier between the mother and fetus, placenta plays a pivotal role in mediating and regulating iron transport. Imbalances in iron metabolism correlate with severe adverse pregnancy outcomes. Like most other nutrients, iron exhibits a U-shaped risk curve. Apart from iron deficiency, iron overload is also dangerous since labile iron can generate reactive oxygen species, which leads to oxidative stress and activates ferroptosis. In this review, we summarized the molecular mechanism and regulation signals of placental iron trafficking under physiological conditions. In addition, we revealed the role of iron metabolism and ferroptosis in the view of preeclampsia and gestational diabetes mellitus, which may bring new insight to the pathogenesis and treatment of pregnancy-related diseases.

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“…There is a large body of evidence demonstrating that oxidative stress plays a very important role in the progression of diabetes and its complications [3,5,6]. Therefore, a therapeutic agent that has both antidiabetic and antioxidant activities would be the preferred choice for diabetes.…”

Section: α-Glycosidase and Ptp1b Inhibition Activitiesmentioning

confidence: 99%

“…Reactive oxygen species are produced by living organisms because of normal cellular metabolism and environmental factors, which can damage cell structures and alter their functions [1]. The balance between oxidant and antioxidant in favor of oxidants is termed "oxidative stress" [2], which may cause many diseases, including diabetes mellitus [3] and cancer [4]. Notably, much evidence indicates that oxidative stress plays a very important role in the progression of diabetes and its complications [3,5,6], for instance, diabetic nephropathy, cardiomyopathy, and diabetic neuropathy [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…The balance between oxidant and antioxidant in favor of oxidants is termed "oxidative stress" [2], which may cause many diseases, including diabetes mellitus [3] and cancer [4]. Notably, much evidence indicates that oxidative stress plays a very important role in the progression of diabetes and its complications [3,5,6], for instance, diabetic nephropathy, cardiomyopathy, and diabetic neuropathy [7,8]. In addition, uncontrolled chronic hyperglycemia is directly related to free radical overload [9].…”

Section: Introductionmentioning

confidence: 99%

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Novel Antioxidants and α-Glycosidase and Protein Tyrosine Phosphatase 1B Inhibitors from an Endophytic Fungus Penicillium brefeldianum F4a

Bai

Zhang

et al. 2021

JoF

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Oxidative stress plays a very important role in the progression of diabetes and its complications. A therapeutic agent that is both antidiabetic and antioxidant would be the preferred choice for the treatment of diabetes. The crude extract of the endophytic fungus Penicillium brefeldianum F4a has significant antioxidant and α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) inhibition activities. Chemical investigation of P. brefeldianum F4a using an activity-guided isolation led to the discovery of three new compounds called peniorcinols A–C (1–3) along with six known compounds: penialidins A (4), penialidin F (5), myxotrichin C (6), riboflavin (7), indole-3-acetic acid (8), and 2-(4-hydroxy-2-methoxy-6-methylphenyl) acetic acid (9). Their chemical structures were established by their NMR and HRESIMS. The absolute configurations of 1 and 3 were determined by experimental and calculated electronic circular dichroism (ECD). Their antioxidant activities were evaluated by DPPH• and ABTS•+ scavenging assays. Compounds 1–6 and 8–9 showed moderate to strong free radical scavenging activities. Significantly, 4–6 exhibited more potent ABTS•+ scavenging activity than that of the positive control. Their α-glycosidase and PTP1B inhibition activities were tested. Among them, compound 3 showed α-glucosidase inhibition activity, and compounds 7 and 8 showed PTP1B inhibitory activity for the first time. It is worth noting that 3 and 8 displayed both antioxidant and α-glycosidase or PTP1B inhibition activities. These finding suggest that compounds 3 and 8 could be used as lead compounds to generate new potent drugs for the treatment of oxidative stress-related diabetes.

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Association between early oxidative DNA damage and iron status in women with gestational diabetes mellitus

Cited by 9 publications

References 54 publications

Evaluation of first and second trimester maternal thyroid profile on the prediction of gestational diabetes mellitus and post load glycemia

Evaluation of first and second trimester maternal thyroid profile on the prediction of gestational diabetes mellitus and post load glycemia

Iron Metabolism and Ferroptosis in Physiological and Pathological Pregnancy

Novel Antioxidants and α-Glycosidase and Protein Tyrosine Phosphatase 1B Inhibitors from an Endophytic Fungus Penicillium brefeldianum F4a

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