Association between dyslipidemia and residual renal function in patients on chronic peritoneal dialysis

Hy, Chen; Tw, Kao; Jw, Huang; Tsai, Tun‐Jun; Kd, Wu

doi:10.5414/cnp70233

Cited by 8 publications

(6 citation statements)

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“…Several investigations, including the present one, have shown that ESRD patients mainly have more elevated TG and non-HDL-C but not LDL-C (14,28). This may partially explain why the association between fetuin A and dyslipidemia occurs mainly on the non-HDL-C and TG components.…”

Section: Discussionsupporting

confidence: 46%

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Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Chen¹,

Chiu²,

Hsu³

et al. 2009

European Journal of Endocrinology

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Background: Fetuin A, a predictor of cardio-vascular (CV) mortality in dialysis patients has been associated with dyslipidemia in non-diabetic coronary artery disease. Truncal obesity is linked to dyslipidemia and also predicts CV mortality. This study had aimed to investigate the associations among fetuin A, truncal obesity, and dyslipidemia in hemodialysis (HD) patients. Methods: One hundred and nine non-diabetic HD patients were evaluated. Waist circumference, highly sensitive C-reactive protein (hs-CRP), fetuin A, and lipoprotein levels (i.e. total cholesterol (T-CHO), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), non-HDL-C, and triglyceride (TG)) were measured for analysis of correlations. The patients were divided into tertiles by fetuin A concentrations. Results: Data from 63 women and 46 men aged 60G13 years were analyzed. Patients in the highest tertile of fetuin A (0.33-0.51 g/l) had higher serum creatinine, albumin, T-CHO, LDL-C, non-HDL-C, and TG, more truncal obesity and lower hs-CRP than patients in the lowest tertile (all P!0.05). In multi-variable linear regression analysis, fetuin A was independently associated with TG level and total iron binding capacity after adjustments for age, hemoglobin, albumin, calcium, body mass index, and hs-CRP. Patients in the highest fetuin A tertile had 3.2-and 4.4-fold higher incidence of truncal obesity (PZ0.038) and hyper-triglyceridemia (PZ0.015) independent of nutritional status and inflammation. Conclusion: Fetuin A is positively associated with truncal obesity and dyslipidemia, which are independent of malnutrition and inflammation. It may predict visceral adiposity and dyslipidemia, especially TG and TG-rich lipoproteins, in HD patients.

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Section: Discussionsupporting

confidence: 46%

“…In previous investigations, chronic dialysis patients frequently have low HDL-C and LDL-C levels than the general population and predict worse all-cause outcomes (14,15). Although the prevalence of dyslipidemia is extremely high in dialysis patients, the exact relationship of fetuin A and dyslipidemia in these patients is unknown.…”

Section: Introductionmentioning

confidence: 99%

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Chen¹,

Chiu²,

Hsu³

et al. 2009

European Journal of Endocrinology

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“…Second, PD patients probably may encounter more problems in fluid and weight control, which may be followed by dyslipidemia [ 18 ]. Chen et al [ 19 ] described in their longitudinal cohort study that low LDL was correlated with PD patients without RRF and that change in HDL was correlated with faster RRF deterioration. The 4D and AURORA study only focused on HD patients; thus, we believe that the effect of lipid profile on mortality in PD patients with RRF is similar to that in non-dialysis-dependent CKD patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cholesterol Levels on Mortality in Patients with Long-Term Peritoneal Dialysis Based on Residual Renal Function

Lin

Peng

et al. 2018

Nutrients

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The effect of dyslipidemia on peritoneal dialysis (PD) patients based on the presence of residual renal function (RRF; renal creatinine clearance >2 mL/min/1.73 m2) is unknown. Data from the Taiwan Renal Registry Data System between 2005 and 2012 were analyzed to estimate the association between dyslipidemia and mortality in PD patients. Long-term PD patients (n = 8032) were divided into groups with (RRF; n = 2691, 33.5%) and without RRF (non-RRF; n = 5341, 66.5%). The primary outcome was three-year mortality, and multivariate Cox regression was used for survival analysis. After stratifying the total cholesterol (TC) level between the first and third years, the hazard ratio for mortality was estimated. In the non-RRF group, TC < 120 mg/dL was associated with independently increased risk of mortality. In the RRF group, low TC was not independently correlated with increased mortality, but TC > 285 mg/dL was associated with increased risk. PD patients with higher level of TC (>200 mg/dL) in both first and third years of dialysis had significantly lower risk of mortality. In this nationwide cohort study, PD patients without RRF who had low TC level had the highest mortality, in contrast to those with RRF. Malnutrition in long-term PD patients without RRF is an important issue to be monitored.

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“…Previous studies demonstrated that reduced kidney function is independently associated with low high-density lipoprotein cholesterol (HDL-C) levels in patients with end-stage renal disease (ESRD), those on hemodialysis, and those with stage 3–5 chronic kidney disease (CKD) [3-5], and reduced HDL-C levels are a hallmark of ESRD-related dyslipidemia [6]. Some researchers are convinced that this correlation between kidney function and HDL-C is due to the dysregulation of HDL-C metabolism caused by reduced kidney function [7]. …”

Section: Introductionmentioning

confidence: 99%

Association of High-Density Lipoprotein Cholesterol with the Estimated Glomerular Filtration Rate in a Community-Based Population

et al. 2013

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BackgroundReduced kidney function is independently associated with low high-density lipoprotein cholesterol (HDL-C) levels in patients with end-stage renal disease (ESRD), those on hemodialysis, and those with stage 3–5 chronic kidney disease (CKD). However, epidemiological data investigating the relationship between HDL-C levels and kidney function in the general population with roughly normal kidney function are limited, and the results are also inconsistent. The aim of this study was to evaluate the relationship between HDL-C levels and the estimated glomerular filtration rate (eGFR) in a community-based population in China.MethodsThis was a community-based cross-sectional survey. In total, 4925 participants (age range, 18–96 years; mean, 51.30±11.98 years) were recruited during routine health status examinations. A questionnaire was used to ascertain age, smoking status, and the history of hypertension and diabetes mellitus for each participant. We measured the body mass index, waist circumference, systolic and diastolic blood pressure, and fasting glucose, total cholesterol, triglyceride, HDL-C, low-density lipoprotein cholesterol, uric acid, and serum creatinine level of each participant. eGFR was evaluated using the Chinese modified Modification of Diet in Renal Disease equation.ResultsThe HDL-C level was higher in the first quartile (lowest quartile) of eGFR than in the fourth quartile (the highest quartile). Additionally, HDL-C levels decreased as eGFR decreased. Pearson’s correlation analysis revealed that HDL-C levels were associated with eGFR (r=0.16). After adjustment for some confounders, HDL-C was independently associated with all quartiles of eGFR in the participants.ConclusionsHDL-C was independently associated with kidney function in a community-dwelling general population. The association between low HDL-C levels and a decreased eGFR gradually strengthened as eGFR declined.

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Association between dyslipidemia and residual renal function in patients on chronic peritoneal dialysis

Cited by 8 publications

References 0 publications

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Effects of Cholesterol Levels on Mortality in Patients with Long-Term Peritoneal Dialysis Based on Residual Renal Function

Association of High-Density Lipoprotein Cholesterol with the Estimated Glomerular Filtration Rate in a Community-Based Population

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