Association between Duration of Folic Acid Supplementation during Pregnancy and Risk of Postpartum Depression

Yan, Jing; Liu, Yuyan; Cao, Lujia; Zheng, Youli; Li, Wen; Huang, Guowei

doi:10.3390/nu9111206

Cited by 50 publications

(36 citation statements)

References 40 publications

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“…Differences in depression screening tool (Kessler Psychological Distress Scale versus EPDS) and time of sample collection (antepartum versus postpartum) may explain the divergent results observed in the two studies. Other signi cant studies exploring the association between B-vitamin and PPD measured only dietary intake of folate, vitamin B6 and B12 (25) or supplementation (26)(27)(28) without measuring the circulating levels of vitamin B12 (29)(30)(31) . We conducted a pilot study to observe the status of vitamin B12, total folate and hcy in 24-48 hours post delivery, and found higher hcy levels in depressed women when compared to the non-depressed.…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Dhiman

Pillai

Wilson

et al. 2020

Preprint

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BackgroundVitamin B12 is an essential micronutrient for neurological function, as it leads to the regeneration of methionine from homocysteine, which is precursor of biologically active molecule SAM. Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression. MethodsWomen attending postpartum clinic at 6 weeks post-delivery were screened for the presence of depressive symptoms using Edinburg postpartum depression scale (EPDS). Based on a cut-off of 10, two groups were taken- women with probable depression with EPDS score>10 (n=217) and women without probable depression with EPDS score<10(n=217). Plasma total vitamin B12, holotranscobalamin, homocysteine, MMA, 5-methyl THF, SAM and serotonin levels were estimated using commercially available ELISA kits. Combined B12(cB12) score was calculated and analysis of resulting data was done using SPSS ver20.0. ResultsTotal vitamin B12 was significantly lower (p=0.001) and MMA (p=0.002) and 5-methyl THF(p<0.001) levels were higher in women with probable depression than women without probable depression. Combined B12 index was also lower in women with probable PPD (p=0.001). Women in the lowest vitamin B12 quartile had 4.53 times higher likelihood of probable postpartum depression (p < 0.001). Decreasing vitamin B12 (OR = 0.394; 95% CI: 0.189-0.822) and cB12 (OR=0.293; 95% CI:0182-0.470) and increasing MMA (OR = 2.14; 95% CI: 1.63-2.83) and 5-methyl THF levels (OR = 3.29; 95% CI: 1.59-6.83) were significantly associated with the risk of PPD.ConclusionLow vitamin B12 may contribute to depressive symptoms in vulnerable postpartum period.

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Section: Discussionmentioning

confidence: 99%

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Dhiman

Pillai

Wilson

et al. 2020

Preprint

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“…FA significantly improved depression‐like behaviors in stress‐induced rats (Wróbel et al, ). FA supplementation for more than 6 months during pregnancy was associated with a decreased risk of p ostpartum depression 6–12 weeks after delivery in Chinese women (Yan et al, ). Interestingly, according to the results of a study by Van et al (), there is no risk for FA deficiency‐induced disorders when the low‐dose ISO is used.…”

Section: Low‐dose Iso and Fa Combination Could Be A Plausible Proactimentioning

confidence: 99%

Depression, isotretinoin, and folic acid: A practical review

Abdelmaksoud

Vojvodić

Ayhan

et al. 2019

Dermatologic Therapy

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Isotretinoin (ISO) is a first‐generation retinoid discovered in 1952 and approved by the FDA for the treatment of nodulocystic acne in 1982. The anti‐inflammatory properties of ISO have found its use in disorders other than acne. ISO can create psychiatric problems, including depression and suicidal ideation. These neuropsychiatric problems are very similar to disorders secondary to hyperhomocysteinemia (HHcy), vitamin B12, and folic acid (vitamin B9) deficiencies. Given that previous literature suggested folate supplementation improved the efficacy of traditional antidepressant medications, clinicians may wish to consider folate supplementation for patients with depression or possible depressive symptoms, such as acne patients with genetic susceptibility. Brain‐derived neurotrophic factor may be a cytokine‐specific screening biomarker in immune‐based antidepressive therapy.

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“…Em estudo sobre a associação da suplementação de ácido fólico e sintomas de depressão pós-parto, após analisar a suplementação em 1592 gestantes chinesas, Yan et al (2017) concluíram que a suplementação de 400 μg/dia de ácido fólico durante a gestação, em período superior a 6 meses reduz os sintomas depressivos que normalmente surgem entre 6 e 12 semanas pós-parto. Lewis et al…”

Section: Yan Et Al (2017)unclassified

Estratégias Dietéticas Para a Gestação E Lactação

Medeiros¹,

Araújo²,

Pereira³

2019

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RESUMOEm virtude do pequeno número de estudos que analisam os benefícios de mudanças dietéticas no desenvolvimento da gestação, do parto e da lactação, esta revisão sistemática buscou investigar os efeitos da oferta de suplementação de nutrientes e outras modificações dietéticas, em desfechos desejáveis nos processos de gestação e lactação, bem como na prevenção de desfechos clínicos indesejáveis nos recém-nascidos. Foi estruturada conforme as recomendações Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), resultando na seleção de 11 artigos para comporem os resultados do estudo. Buscaram-se artigos originais, indexados às bases de dados eletrônicas PubMed Central (PMC); Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Scientific Eletronic Library Online (SciELO) e publicados entre 2008 e 2018, nos idiomas: português, inglês e espanhol. Os descritores estão listados no Medical Subject Heading (MeSH) -em inglês, e nos Descritores em Ciências da Saúde (DeCS)-em português. Com esse estudo pode-se observar a importância da nutrição durante o período gravídico puerperal e seu impacto na saúde materno-infantil. Nota-se que a qualidade de vida da mãe e, principalmente, a qualidade da sua alimentação são imprescindíveis para um bom desenvolvimento fetal. Sendo assim, a avaliação nutricional completa, com foco em uma intervenção precoce, para correção dos desvios diagnosticados, faz-se essencial durante todo o período gestacional e puerperal. PALAVRAS-CHAVE: Resultado da gravidez. Período pós-parto. Suplemento alimentar. DIETARY STRATEGIES FOR PREGNANCY AND LACTATION: A SYSTEMATIC REVIEWABSTRACT Because of the small number of studies that examine the benefits of dietary changes in the development of pregnancy, childbirth and lactation, this systematic review sought to investigate the effects of nutrient supplementation and other dietary changes on desirable outcomes in gestational processes and lactation, as well as in preventing undesirable clinical outcomes in newborns. It was structured according to

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Association between Duration of Folic Acid Supplementation during Pregnancy and Risk of Postpartum Depression

Cited by 50 publications

References 40 publications

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Depression, isotretinoin, and folic acid: A practical review

Estratégias Dietéticas Para a Gestação E Lactação

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