Association Between Distance From A Heavily Transited Avenue, Indoor Air Quality And Risk Of Asthma In A Poor Peri-urban Shanty-town In Lima, Peru

Baumann, Lauren; Robinson, Colin; Gilman, Robert H.; Hansel, Nadia N.; Cabrera, Lilia; Wise, Robert A.; Barnes, Kathleen C.; Breysse, Patrick N.; Hernandez, Juan E.; Romero, Karina; Combe, J; Gómez, Alfonso; Checkley, William

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2508

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“…Since our community is relatively homogenous in sociodemographic composition, it provides a naturally-controlled environment to study the effects of distance from a major roadway on the risk of asthma and atopy. The results of this study were presented in part previously in an abstract(19). …”

Section: Introductionmentioning

confidence: 99%

Effects of distance from a heavily transited avenue on asthma and atopy in a periurban shantytown in Lima, Peru

Baumann

Robinson

Combe

et al. 2011

Journal of Allergy and Clinical Immunology

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Background Proximity to roadways increases the risk of asthma in developed countries; however, relatively little is known about this relationship in developing countries, where rapid and uncontrolled growth of cities has resulted in urban sprawl and heavy traffic volumes. Objective Determine the effect of distance from a heavily transited avenue on asthma symptoms and quantitative respiratory outcome measures in a peri-urban shanty town in Lima, Peru. Methods We enrolled 725 adolescents aged 13–15 years, administered a survey on asthma symptoms and measured spirometry, response to allergy skin testing and eNO. We calculated distances from the main avenue for all households and measured indoor PM in 100 households. We used multivariable regression to model the risk of asthma symptoms, risk of atopy, eNO and FEV1/FVC as a function of distance. Results Compared against 384 meters, the odds of current asthma symptoms in households living within 100 meters increased by a factor of 2 (p<0.05). The odds of atopy increased by a factor of 1.07 for every 100 meters difference in the distance from the avenue (p=0.03). We found an inverse relationship in pre-bronchodilator FEV1/FVC and distance to the avenue in females (p=0.01) but not in males. We did not find an association between eNO or household PM levels and distance. Conclusion Living in close proximity to a high traffic-density avenue in a peri-urban community in Peru was associated with a greater risk of asthma symptoms and atopy. Regulation of mobile source pollutants in peri-urban areas of developing countries may help reduce the burden of asthma symptoms and atopy.

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Section: Introductionmentioning

confidence: 99%