Association between Dietary Zinc Intake and Hyperuricemia among Adults in the United States

Abstract

We aim to explore the associations between dietary zinc intake and hyperuricemia (HU) in United States (US) adults. 24,975 US adults aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2014 were stratified into quintiles based on zinc intake. All dietary intake measured through 24-h dietary recalls. Multivariable logistic regression analysis was performed to examine the association between zinc intake and HU after adjustment for possible confounders. For males, compared with respondents consuming less than 7.33 mg zinc daily, the adjusted odds ratios (ORs) were 0.83 (95% CI, 0.71, 0.97) among those consuming 10.26–13.54 mg zinc daily, 0.78 (95% CI, 0.63–0.96) among those consuming 18.50 mg or greater, and p for the trend was 0.0134. For females, compared with respondents consuming less than 5.38 mg zinc daily, the OR was 0.78 (95% CI, 0.63, 0.97) among those consuming 9.64–12.93 mg zinc daily, and p for the trend was 0.3024. Our findings indicated that dietary zinc intake is inversely associated with HU in US men and women, independent of some major confounding factors.

Prediction model of artificial neural network for the risk of hyperuricemia incorporating dietary risk factors in a Chinese adult study

“…Some studies have indicated that HU was affected prominently by lifestyles such as diet habits and demographic characteristics (29)(30)(31)(32). For instance, some previous studies have found that high intake of salt was strongly related to HU (33,34).…”

Associations of co-exposure to metals with serum uric acid and hyperuricemia: A cross-sectional study

“…Similarly, a small-sample occupational study indicated that manganese exposure led to low UA concentrations in urine, indicating high UA accumulation in serum [58]. As regard to zinc, Zhang et al found that dietary zinc intake was inversely associated with the risk of hyperuricemia in both sexes, but our results indicated that urinary zinc concentrations were associated with increased SUA levels in females [21]. There might exist no con ict in the two results.…”

“…In a study using a semi-quantitative food frequency questionnaire to evaluate dietary magnesium intake, an inverse association of magnesium intake with the prevalence of hyperuricemia was suggested in the male population [20]. According to the dietary intake results of NHANES 2001-2014, dietary zinc intake was associated with reduced risk of hyperuricemia in both sexes [21].…”

Factors Attenuating Zinc Deficiency Improvement in Direct-Acting Antiviral Agent-Treated Chronic Hepatitis C Virus Infection

“…It was previously reported that dietary zinc intake was inversely associated with hyperuricemia in a male population in China [ 23 ]. Another similar study suggested that low dietary zinc intake was significantly associated with hyperuricemia in both males and females in the United States [ 24 ]. Foods containing high concentrations of zinc, such as whole grains, dairy products, nuts, and soy products, were reported to have a protective effect against hyperuricemia [ 24 ].…”

“…Another similar study suggested that low dietary zinc intake was significantly associated with hyperuricemia in both males and females in the United States [ 24 ]. Foods containing high concentrations of zinc, such as whole grains, dairy products, nuts, and soy products, were reported to have a protective effect against hyperuricemia [ 24 ]. It was also revealed that alcohol consumption can result in both hyperuricemia and low zinc status, which can arise from impaired intestinal absorption and increased urinary excretion [ 11 ].…”