Association Between Dietary Zinc Intake and Increased Renal Function in US Adults

Liu, Chang; Zhang, Hao; Yang, Yuwei; Cao, Yan; Liang, Dan

doi:10.1007/s12011-023-03969-6

Cited by 2 publications

(2 citation statements)

References 70 publications

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“…An increased risk of having low eGFR was associated with serum Zn levels <74 µg/dL and blood Cd levels > 0.53 µg/L [135]. Among participants, enrolled in the U.S. NHANES 2003NHANES -2018, a biphasic dose-response relationship was noted between Zn intake levels and CKD risk, indicated by albuminuria or low eGFR [136]. The overall mean Zn intake level was 11.85 mg/day, while a significant decrease in risk of CKD was observed at Zn intake levels not higher 16.46 mg/day.…”

Section: Evidence For Protetive Effects Of Zincmentioning

confidence: 93%

Modulation of the Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters

Cirovic,

Yimthiang

et al. 2024

Preprint

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Zinc (Zn) is the second most abundant metal in the human body, and is essential for the function of 10% of all proteins. As metals cannot be synthesized or degraded, they must be assimilated from diet by specialized transport proteins, which unfortunately also provide an entry route for the toxic metal pollutant cadmium (Cd). The intestinal absorption of Zn depends on the composition of food that is consumed, firstly the amount of Zn itself, and then the quantity of other food constituents such as phytate, protein and calcium (Ca). In cells, Zn is involved in regulation of intermediary metabolism, gene expression, cell growth, differentiation, apoptosis, and antioxidant defense mechanisms. Cellular influx, efflux, subcellular compartmentalization, and trafficking of Zn are coordinated by transporter proteins, the Solute-Linked Carrier 30A and 39A (SLC30A and SLC39A), known as the ZnT and the Zrt-/Irt-like protein (ZIP). Because of its chemical similarity with Zn and Ca, Cd disrupts the physiological functions of both. The concurrent induction of a Zn efflux transporter ZnT1 (SLC30A1) and metallothionein by Cd disrupts the homeostasis and reduces the bioavailability of Zn. The present review highlights the increased mortality and the severity of various diseases, including those induced by COVID-19 infections, among Cd-exposed persons and the roles of Zn and other transport proteins in the manifestation of Cd cytotoxicity. Special emphasis is given to the potential protective effects of Zn against bone, lung and heart diseases associated with Cd exposure. The difficult challenge of determining a permissible intake level of Cd is discussed in relation to the recommended dietary Zn intake levels.

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Section: Evidence For Protetive Effects Of Zincmentioning

confidence: 93%

Modulation of the Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters

Cirovic,

Yimthiang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…A dietary Zn of 16.46 mg/day was sufficient to reduce the adverse effect of Cd on kidneys (low GFR) among participants in the NHANES 2003–2018 (n = 37,195), where an overall mean Zn intake level was 11.85 mg/day. In this study, Zn intake levels showed a U-shaped dose–response relationship with CKD risk [ 146 ], meaning that the Zn intake should not be too low (≤6.64 mg/day) or too high (>16 mg/day). Accordingly, dietary Zn levels of 15–16 mg/day, higher than RDA values, may help reduce excessive health risks due to Cd exposure.…”

Section: Global Health Threat Of Environmental Cadmiummentioning

confidence: 99%

Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters

Cirovic,

Yimthiang

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Zinc (Zn) is the second most abundant metal in the human body and is essential for the function of 10% of all proteins. As metals cannot be synthesized or degraded, they must be assimilated from the diet by specialized transport proteins, which unfortunately also provide an entry route for the toxic metal pollutant cadmium (Cd). The intestinal absorption of Zn depends on the composition of food that is consumed, firstly the amount of Zn itself and then the quantity of other food constituents such as phytate, protein, and calcium (Ca). In cells, Zn is involved in the regulation of intermediary metabolism, gene expression, cell growth, differentiation, apoptosis, and antioxidant defense mechanisms. The cellular influx, efflux, subcellular compartmentalization, and trafficking of Zn are coordinated by transporter proteins, solute-linked carriers 30A and 39A (SLC30A and SLC39A), known as the ZnT and Zrt/Irt-like protein (ZIP). Because of its chemical similarity with Zn and Ca, Cd disrupts the physiological functions of both. The concurrent induction of a Zn efflux transporter ZnT1 (SLC30A1) and metallothionein by Cd disrupts the homeostasis and reduces the bioavailability of Zn. The present review highlights the increased mortality and the severity of various diseases among Cd-exposed persons and the roles of Zn and other transport proteins in the manifestation of Cd cytotoxicity. Special emphasis is given to Zn intake levels that may lower the risk of vision loss and bone fracture associated with Cd exposure. The difficult challenge of determining a permissible intake level of Cd is discussed in relation to the recommended dietary Zn intake levels.

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Association Between Dietary Zinc Intake and Increased Renal Function in US Adults

Cited by 2 publications

References 70 publications

Modulation of the Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters

Modulation of the Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters

Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters

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