Association between Dietary Tomato Intake and the Risk of Hepatocellular Carcinoma: The Singapore Chinese Health Study

Thomas, Catherine A.; Luu, Hung N.; Wang, Renwei; Adams-Haduch, Jennifer; Jin, Aizhen; Koh, Woon‐Puay; Yuan, Jian‐Min

doi:10.1158/1055-9965.epi-20-0051

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…Intake of tomato and/or lycopene has been associated with reduced risk of several cancers, such as hepatocellular carcinoma [ 17 ], gastric cancer [ 18 ] and prostate cancer [ 19 ]. It has been proposed that lycopene, found in high amounts in tomato, may contribute to cancer prevention, which could be the biological mechanisms in the lower development of cancers with higher consumption of tomato, [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Xie

et al. 2021

Aging

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Previous studies have provided limited evidence for the effect of tomato intake on bladder cancer incidence. This study aimed to evaluate the association between dietary tomato or lycopene consumption and bladder cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression model adjusting for confounders. After a median of 12.5 years of follow-up, 774 incident bladder cancer cases were identified. We found no statistically significant association between dietary intake of raw tomatoes and bladder cancer risk (Adjusted model: HR Q5 VS Q1 = 1.20, 95% CI: 0.95-1.52; P for trend = 0.243). Dietary intakes of tomato catsup, tomato salsa and tomato juice were also not associated with the risk of bladder cancer (all P for trend > 0.05). There was no statistically significant association between dietary consumption of lycopene and bladder cancer risk (Adjusted model: HR Q5 vs. Q1 = 1.04, 95% CI 0.82-1.33; P for trend = 0.590). In summary, analysis of the PLCO study suggested that dietary consumption of tomato or lycopene was not associated with the risk of bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Xie

et al. 2021

Aging

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“…The Singapore Chinese Health Study is a prospective population-based cohort study that recruited 63,257 Chinese men and women, aged 45–74 years, in Singapore, between April 1993 and December 1998 [ 31 ]. The eligible subjects had to be permanent residents of Singapore government-built housing and belong to one of two major Chinese dialect groups—Hokkien or Cantonese.…”

Section: Methodsmentioning

confidence: 99%

Association between Pre-Diagnostic Serum Bile Acids and Hepatocellular Carcinoma: The Singapore Chinese Health Study

Thomas

Luu

Wang

et al. 2021

Cancers

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Hepatocellular carcinoma (HCC) is a commonly diagnosed malignancy with poor prognosis. Rising incidence of HCC may be due to rising prevalence of metabolic dysfunction-associated fatty liver disease, where altered bile acid metabolism may be implicated in HCC development. Thirty-five bile acids were quantified using ultra-performance liquid chromatography triple-quadrupole mass spectrometry assays in pre-diagnostic serum of 100 HCC cases and 100 matched controls from the Singapore Chinese Health Study. Conditional logistic regression was used to assess associations for bile acid levels with risk of HCC. Conjugated primary bile acids were significantly elevated whereas the ratios of secondary bile acids over primary bile acids were significantly lower in HCC cases than controls. The respective odds ratios and 95% confidence intervals of HCC were 6.09 (1.75–21.21) for highest vs. lowest tertile of cholic acid species and 30.11 (5.88–154.31) for chenodeoxycholic acid species. Doubling ratio of taurine-over glycine-conjugated chenodeoxycholic acid was associated significantly with 40% increased risk of HCC whereas doubling ratio of secondary over primary bile acid species was associated with 30–40% reduced risk of HCC. In conclusion, elevated primary bile acids and taurine over glycine-conjugated ratios were strongly associated with HCC risk whereas the ratios of secondary bile acids over primary bile acids were inversely associated with HCC risk.

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“…Lycopene, a bioactive deep-red pigment naturally synthesized by fruits and vegetables, is the most abundant carotenoid in red tomatoes and tomato-based products, including ketchup, tomato juice, and pizza sauce ( Ilahy et al, 2019 ). Human and experimental studies have reported that lycopene can influence the development and progression of HCC ( Mein et al, 2008 ; Ip and Wang, 2013 ; Stice et al, 2018 ; Thomas et al, 2020 ). For instance, in studies conducted using hepatoma cell lines lycopene inhibited cell growth, migration, and invasion ( Huang et al, 2008 ; Yang et al, 2012 ; Jhou et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-Cancer Effects of Lycopene in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

et al. 2020

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Introduction: Globally, hepatocellular carcinoma (HCC) is the sixth most diagnosed cancer and the third important cause of cancer-related death. As there are only two targeted drugs for the treatment of advanced HCC-that merely extend survival by a few months-the need for alternative treatments is inevitable. Lycopene, a carotenoid that is known to be most abundant in red tomatoes and tomato-based products, has been investigated for its anticancer activity in various types of cancers including HCC. This review was conducted to evaluate the effects of lycopene on HCC from animal models to pave the way for further clinical studies. Methods: Electronic databases and search engines including PubMed, EMBASE, and Google Scholar were searched for original records addressing the anticancer effect of lycopene in animal models of HCC. Data were extracted using a format prepared in Microsoft Excel and exported to Stata 15.0 for analyses. A meta-analysis was performed using a random-effects model at a 95% confidence level for the outcome measures: tumor incidence, number, and growth (tumor volume and size). The presence of publication bias between studies was evaluated using Egger's test and funnel plot. The study protocol was registered in the PROSPERO database with reference number: CRD42019159312. Results: The initial database search yields 286 articles, of which 15 studies met the inclusion criteria. The characteristics of the included studies were a bit diversified. The studies involved a total of 644 animals (312 treatment and 332 control groups) and mice shared the majority (488) followed by rats (117) and ferrets (39). The meta-analysis showed that lycopene significantly reduced the incidence [RR 0.8; 95% CI 0.69, 0.92 (p=0.00); I 2 = 30.4%, p=0.16; n=11], number [SMD-1.83; 95% CI-3.10,-0.57 (p=0.01); I 2 = 95.9%, p=0.00; n=9], and growth [SMD-2.13; 95% CI-4.20,-0.04 (p=0.04); I 2 = 94.6%, p=0.00; n=4] of HCC.

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Association between Dietary Tomato Intake and the Risk of Hepatocellular Carcinoma: The Singapore Chinese Health Study

Cited by 15 publications

References 28 publications

Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Association between Pre-Diagnostic Serum Bile Acids and Hepatocellular Carcinoma: The Singapore Chinese Health Study

Anti-Cancer Effects of Lycopene in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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