Association between dietary phytoestrogen intake and bone mineral density varied with estrogen receptor alpha gene polymorphisms in southern Chinese postmenopausal women

Luo, Dongmei; Liu, Yongfei; Zhou, Yin; Zong-wei, Chen; Yang, Ling; Liu, Yong; Xu, Qunying; Xu, Hong; Kuang, Haibin; Huang, Qiren; He, Ming; Peng, Wei

doi:10.1039/c5fo00295h

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…Oral administration of ferutinin, a plant-derived ester of a sesquiterpenic alcohol, which acts as an ERα agonist (IC 50 = 33.1 nM) and an agonist/antagonist for ERβ (IC 50 = 180.5 nM), was able to improve bone regeneration of critical-size bone defects in vivo (Zavatti et al, 2015). Finally, a recent study revealed that in southern Chinese postmenopausal women the PhyEs dietary intake influences the bone mineral density, depending on the different ERα gene polymorfisms (Luo et al, 2015). …”

Section: Natural Xenoestrogensmentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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Xenoestrogens are widely diffused in the environment and in food, thus a large portions of human population is worldwide exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

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Section: Natural Xenoestrogensmentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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“…Other validated dietary collection tools included dietary records or diary (n = 7, 15%) (42,44,62,68,90,150,158), 24-h or 48-h recalls (n = 6, 13%) (44,45,66,69,148,154), brief diet history questionnaire (n = 1, 2%) (94), and dietary history interviews (n = 1, 2%) (162). These methods were used to measure intakes of isoflavones (n = 19, 41%) (48,49,52,63,64,68,69,145,148,149,153,155,160,161,166,167,170,171,174), flavonoids (n = 13, 28%) (42, 46, 63, 114, 146, 147, 156, 162-165, 169, 172, 174, 175), lignans (n = 3, 7%) (147,154,173), phytoestrogens (both isoflavones and lignans) (n = 6, 13%) (45,66,150,151,157,175), and total (poly)phenols (n = 6, 13%) (44,62,…”

Section: Validation Of the Methodsmentioning

confidence: 99%

“…To determine the validity of the dietary assessment tool, 34 (74%) studies used other dietary assessment methods as references, including multiple (n = 7, 21%) (145,154,161,164,165,172,176) or single (n = 11, 32%) (42,44,62,68,94,150,154,155,161,166,170) measurement(s) of dietary records, multiple (n = 1, 3%) (171) or single (n = 4, 12%) (64,146,163,175) weighed food records, multiple 24-h (n = 9, 26%) (44,66,149,156,157,160,(167)(168)(169) or 48-h (n = 1, 3%) recalls (69), or other FFQs (n = 3, 9%) (50,158,168). Meanwhile, 17 (37%) studies compared dietary assessment methods against (poly)phenol biomarkers, from 24-h urine (n = 4, 24%) (45,52,69,170), spot urine (n = 6, 35%) (44,52,62,(148)(149)(150), fasting pla...…”

Section: Validation Of the Methodsmentioning

confidence: 99%

Dietary Assessment Methods to Estimate (Poly)phenol Intake in Epidemiological Studies: A Systematic Review

Sayec

Roberts

et al. 2021

Advances in Nutrition

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Nutritional epidemiological studies have frequently reported associations between higher (poly)phenol intake and a decrease in the risk or incidence of noncommunicable diseases. However, the assessment methods that have been used to quantify the intakes of these compounds in large-population samples are highly variable. This systematic review aims to characterize the methods used to assess dietary (poly)phenol intake in observational studies, report the validation status of the methods, and give recommendations on method selection and data reporting. Three databases were searched for publications that have used dietary assessment methods to measure (poly)phenol intake and 549 eligible full texts were identified. Food-frequency questionnaires were found to be the most commonly used tool to assess dietary (poly)phenol intake (73%). Published data from peer-reviewed journals were the major source of (poly)phenol content data (25%). An increasing number of studies used open-access databases such as Phenol-Explorer and USDA databases on flavonoid content since their inception, which accounted for 11% and 23% of the data sources, respectively. Only 16% of the studies reported a method that had been validated for measuring the target (poly)phenols. For future research we recommend: 1) selecting a validated dietary assessment tool according to the target compounds and target period of measurement; 2) applying and combining comprehensive (poly)phenol content databases such as USDA and Phenol-Explorer; 3) detailing the methods used to assess (poly)phenol intake, including dietary assessment method, (poly)phenol content data source; 4) follow the Strengthening the Reporting of Observational Studies in Epidemiology—Nutritional Epidemiology (STROBE-nut) framework; and 5) complementing dietary intake assessment based on questionnaires with measurement of (poly)phenols in biofluids using appropriate and validated analytical methods.

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“…Phytoestrogens are nonsteroidal compounds that are chemically similar to animal estrogens and can directly or indirectly bind to estrogen receptors, exhibiting certain estrogenic or anti‐estrogenic effects. Phytoestrogens have been reported to have anti‐osteoporosis effects, and the effects were related to estrogen receptor alpha (Luo et al., 2015). Lignans such as enterodiol ( ED ) and enterolactone ( EL ) are one category of phytoestrogens, in addition to isoflavones such as genistein and daidzein, as well as coumarins such as coumestrol and wedelolactone (Luo et al., 2015; Tu et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Anti‐osteoporosis effects of mammalian lignans and their precursors from flaxseed and safflower seed using zebrafish model

Yang,

Wu,

Zhuang

et al. 2023

Journal of Food Science

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Secoisolariciresinol diglucoside (SDG) and tracheloside (TCL) are the main lignan components of flaxseed cake and safflower seed cake, which are by‐products of oil extraction. Both SDG and TCL are metabolized into mammalian lignan enterolactone (EL) with the involvement of intestinal bacteria. In this research, we evaluated the anti‐osteoporosis effects of SDG and the in vivo metabolites EL and enterodiol (ED) prepared in our previous work, as well as the newly isolated chemical constituents from safflower seed, including TCL, the lactone ring opening product of TCL (OTCL) and two alkaloids on the alloxan‐induced zebrafish model. All the compounds showed significant anti‐osteoporosis effects at 80 µM, with p < 0.05 for EL and p < 0.001 for other compounds compared with the model. SDG and TCL showed the most significant and concentration‐dependent effects, with p < 0.001 compared with model at 20 µM. The alkaloids, N‐coumaroylserotonin glucoside and N‐feruloylserotonin glucoside, also showed anti‐osteoporosis at 20 µM with p < 0.01, whereas EL, ED, and OTCL showed no significant effects. Quantitative real‐time polymerase chain reaction revealed that SDG and TCL upregulated the expression of osteogenic genes Runx2, SP7, OPG, Col1a1a, Alp, ON, OPN, and OCN in alloxan‐treated zebrafish. The in vivo metabolite of lignans, EL, showed significant anti‐inflammatory effect (p < 0.01) at 20 µM, which might also help to combat osteoporosis and other complications caused by excessive immune response in the body. The results provided scientific data for using the oil extraction by‐products as sources of anti‐osteoporosis compounds.Practical ApplicationThis study found that lignans in flaxseed cake and safflower seed cake exhibited anti‐osteoporosis effects by upregulating the expression of osteogenic genes, making the oil extraction by‐products sources of anti‐osteoporosis compounds.

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Association between dietary phytoestrogen intake and bone mineral density varied with estrogen receptor alpha gene polymorphisms in southern Chinese postmenopausal women

Abstract: the association of the dietary phytoestrogen intake and BMD in southern Chinese postmenopausal women varied with ERα gene polymorphisms.

Cited by 8 publications

References 32 publications

Risks and benefits related to alimentary exposure to xenoestrogens

Risks and benefits related to alimentary exposure to xenoestrogens

Dietary Assessment Methods to Estimate (Poly)phenol Intake in Epidemiological Studies: A Systematic Review

Anti‐osteoporosis effects of mammalian lignans and their precursors from flaxseed and safflower seed using zebrafish model

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