Association between Dietary Patterns Reflecting C-Reactive Protein and Metabolic Syndrome in the Chinese Population

Yu, Huan; Wen, Qiaorui; Lv, Jun; Sun, Dianjianyi; Ma, Yuan; Man, Sailimai; Yin, Jianchun; Tong, Mingkun; Wang, Bo; Yu, Canqing; Li, Liming

doi:10.3390/nu14132566

Cited by 4 publications

(5 citation statements)

References 29 publications

(35 reference statements)

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“…Taken together, our study results and current evidence suggest that carotenoids' and polyphenols' intake and their plasma levels and metabolites have the potential to lower inflammation and MetS-related markers [46,68,69]; however, no carotenoids/polyphenols or carotenoids-/polyphenols-rich food can influence all MetS features [70]. A varied diet based on foods rich in polyphenols and carotenoids, mainly in the form of health-promoting nutritional models (the Mediterranean diet, DASH, and the Okinawa diet) may be beneficial at the onset and progression of MetS and in reducing the associated risk of developing diabetes or cardiovascular diseases [71].…”

Section: Discussionsupporting

confidence: 74%

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

et al. 2023

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Metabolic syndrome (MetS) is characterized by increased pro-oxidative stress and a chronic inflammation state and their consequent alterations. Several studies have highlighted the protective effect of carotenoids and polyphenols in MetS patients. This study aimed to evaluate the plasma level of selected carotenoids and polyphenols and to determine their relationship with MetS severity, MetS components, and inflammatory markers in Polish adults with metabolic disorders. It was designed as a cross-sectional study. The final study group comprised 275 adults, including 158 women and 117 men. Data were collected on the frequency of consumption of selected food groups. Anthropometric measurements and blood samples were taken to determine the concentration of carotenoids, polyphenols, and indicators (parameters) of metabolic disorders. Plasma concentrations of selected carotenoids and polyphenols were low in adults with MetS. The highest concentrations of carotenoids and polyphenols in the blood were observed for lutein and phenolic acids (including gallic and p-coumaric acids). Nevertheless, a correlation was found between the individual bioactive compounds and MetS components. In terms of the lipid profile, our study showed that the plasma of the selected carotenoids and polyphenols positively correlated with HDL cholesterol (zeaxanthin; total carotenoids), LDL cholesterol (chlorogenic acid), triglycerides (lycopene), and the total cholesterol (kaempferol). We found that the level of CRP as a marker of inflammation negatively correlated with the concentration of zeaxanthin. In our study group, no relationship was found between the dietary antioxidant intensity and the variables studied, which may be attributed to the low frequency of consumption of the sources of bioactive compounds, such as carotenoids and polyphenols, but also to the metabolic disorders. Further research is needed to determine whether these associations are causally related to the metabolic syndrome or are a result of the pathologies of the syndrome or improper diet with a low intake of vegetables and fruit.

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Section: Discussionsupporting

confidence: 74%

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

et al. 2023

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“…Our study had several limitations. (1) This was a small single-center study. All the results in this study can only be applied to the Chinese population and cannot be extrapolated to other countries.…”

Section: Dovepressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…According to research, the global prevalence of MetS has increased over the last 20 years and global prevalence of MetS has been reported to be about 25%, causing huge health, social and economic burdens. 1,2 Therefore, early screening and recognition of MetS are of critical importance worldwide, especially in China, a society with high rates of overweight, dyslipidemia and CVD. 3 Although numerous clinical studies have described an inverse and independent relationship between HDL-C concentration and cardiovascular disease, [4][5][6] several large-scale studies have indicated that HDL-C levels may not always…”

Section: Introductionmentioning

confidence: 99%

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The Association of HDL2b with Metabolic Syndrome Among Normal HDL-C Populations in Southern China

Chen,

Wu,

Feng

et al. 2024

DMSO

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Background The annual prevalence of metabolic syndrome (MetS) is increasing. Therefore, early screening and recognition of MetS are critical. This study aimed to evaluate the association between high-density lipoprotein (HDL) subclasses and MetS and to examine whether they could serve as early indicators in a Chinese community-based population with normal high-density lipoprotein cholesterol (HDL-C) levels. Methods We used microfluidic chip technology to measure HDL subclasses in 463 people with normal HDL levels in 2018. We assessed how HDL subclasses correlated with and predicted insulin resistance (IR) and metabolic syndrome (MetS), evaluated by homeostatic model insulin resistance index (HOMA-IR) and the 2009 International Diabetes Federation (IDF), the American Heart Association (AHA), and the National Heart, Lung, and Blood Institute (NHLBI) criteria, respectively. We used correlation tests and ROC curves for the analysis. Results The results indicate that there was a negative association between HDL2b% and the risk of IR and MetS in both sexes. Subjects in the highest quartile of HDL2b% had a significantly lower prevalence of IR and MetS than those in the lowest quartile (P<0.01). Correlation analysis between HDL2b% and metabolic risk factors showed that HDL2b% had a stronger association with these factors than HDL-C did in both sexes. ROC curve analysis also showed that HDL2b% had significant diagnostic value for IR and MetS compared to other lipid indicators. Conclusion This study showed that MetS alters the distribution of HDL subclasses even when HDL-C levels are within the normal range. HDL-2b% has better diagnostic value for IR and MetS than HDL-C alone and may be a useful marker for early screening.

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“…Particularly, poor diet, including heavy alcohol consumption, excessive salt intake, and a potassium-deficient diet, is closely associated with hypertension ( 8 ). Dietary patterns linked to CRP have been identified as crucial risk factors for hypertension and metabolic syndrome ( 9 ). Elevated levels of DII and CRP are associated with an increased risk of developing hypertension and metabolic syndrome ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Geographic disparities of dietary inflammatory index and its association with hypertension in middle-aged and elders in China: results from a nationwide cross-sectional study

Dong,

Man,

Zhang

et al. 2024

Front. Nutr.

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BackgroundGeographic distribution of dietary inflammatory index (DII) in China has not been thoroughly evaluated and evidence on the association between DII and hypertension among Chinese middle-aged and older population was inadequate.ObjectiveTo investigate the geographic disparities of DII and its association with hypertension among Chinese middle-aged and elders.MethodsData was from the China Adults Chronic Diseases and Nutrition Surveillance (CACDNS 2015) for middle-aged and older participants. The DII for each participant was determined through a combination of 3 days 24 h dietary recall interviews and a food frequency questionnaire. Spatial analysis was employed to investigate the geographic distribution of DII in China. Restricted cubic spline models and binary logistic regression analysis were used to assess the relationship between DII and hypertension. The least absolute shrinkage and selection operator (LASSO) regression was applied for identifying key hypertension-related factors, which was then included in the establishment of a risk prediction nomogram model, with the receiver operating characteristic (ROC) curve and decision curve analysis (DCA) being built to evaluate its discriminatory power for hypertension.ResultsA total of 52,087 middle-aged and older participants were included in the study, among whom 36.6% had hypertension. it revealed that a clear spatial correlation in the national distribution of DII scores (Moran I: 0.252, p = 0.001), with higher DII scores concentrated in the northwest region and lower DII scores concentrated in the southeast region. Hypertensive participants had higher DII scores compared to those without hypertension (OR: 1.507 vs. 1.447, p = 0.003). Restricted cubic spline models and binary logistic regression analysis demonstrated a positive association between DII and hypertension after adjusting for potential confounding factors. There was a significant increasing trend in the proportion of hypertensive individuals as DII scores increase (p for trend = 0.004). The nomogram model, constructed using key factors identified through LASSO regression, demonstrated a robust discriminative capacity, with an area under the curve (AUC) of 73.2% (95% CI, 72.4–74.0%). Decision curve analysis confirmed the reliability and effectiveness of the nomogram model. Sensitivity analysis conducted within the subpopulation aged under 45 years yielded results consistent with the primary analysis.ConclusionIn Chinese adults middle-aged and older, geographic disparities in dietary inflammatory potential are notable, with lower levels observed in the southeastern coastal regions of China and higher levels in the northwestern regions. Meanwhile, there is a positive association between the inflammatory potential of the diet and hypertension. Additional research is needed to investigate regional disparities in dietary inflammatory potential and pinpoint specific dietary patterns associated with lower inflammation.

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Association between Dietary Patterns Reflecting C-Reactive Protein and Metabolic Syndrome in the Chinese Population

Cited by 4 publications

References 29 publications

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

The Association of HDL2b with Metabolic Syndrome Among Normal HDL-C Populations in Southern China

Geographic disparities of dietary inflammatory index and its association with hypertension in middle-aged and elders in China: results from a nationwide cross-sectional study

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