Association Between Dietary Patterns and Serum Leptin-to-Adiponectin Ratio in Apparently Healthy Adults

Jafari‐Vayghan, Hamed; Tarighat‐Esfanjani, Ali; Jafarabadi, Mohammad Asghari; Ebrahimi-Mameghani, Mehrangiz; Ghadimi, Sevda Saleh; Lalezadeh, Zahra

doi:10.1080/07315724.2014.880389

Cited by 14 publications

(9 citation statements)

References 39 publications

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“…The same dietary patterns that were used in CHOICE were also found to be without effect on leptin gene expression in the weight loss context [ 52 ]. Thus, despite a mixture of reports about the effects of dietary patterns on circulating concentrations of leptin [ 49 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ], our findings are very clear-cut and also in agreement with another study in a population of breast cancer survivors in which effects of weight loss and dietary pattern have been reported [ 49 ]. Given that the manner in which leptin gene expression is regulated remains poorly understood [ 64 ], these findings indicate the need to look beyond linkages of leptin to fat mass or body weight per se in efforts to identify new approaches to modulating the secretion of leptin from adipose tissue.…”

Section: Discussionsupporting

confidence: 91%

Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors

et al. 2015

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Women who are obese at the time of breast cancer diagnosis have higher overall mortality than normal weight women and some evidence implicates adiponectin and leptin as contributing to prognostic disadvantage. While intentional weight loss is thought to improve prognosis, its impact on these adipokines is unclear. This study compared the pattern of change in plasma leptin and adiponectin in overweight-to-obese post-menopausal breast cancer survivors during weight loss. Given the controversies about what dietary pattern is most appropriate for breast cancer control and regulation of adipokine metabolism, the effect of a low fat versus a low carbohydrate pattern was evaluated using a non-randomized, controlled study design. Anthropometric data and fasted plasma were obtained monthly during the six-month weight loss intervention. While leptin was associated with fat mass, adiponectin was not, and the lack of correlation between leptin and adiponectin concentrations throughout weight loss implies independent mechanisms of regulation. The temporal pattern of change in leptin but not adiponectin was affected by magnitude of weight loss. Dietary pattern was without effect on either adipokine. Mechanisms not directly related to dietary pattern, weight loss, or fat mass appear to play dominant roles in the regulation of circulating levels of these adipokines.

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Section: Discussionsupporting

confidence: 91%

Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors

et al. 2015

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“…Leptin concentration has been associated with a higher risk of type 2 diabetes, hypertension and chronic heart disease (Kashino et al 2015). According to Jafari-Vayghan et al (2015) the role in the regulation of food intake and energy expenditure is exerted by the leptin. Theoretically, adipose tissue will increase in mass and leads to obesity whenever energy intake exceeds the expenditure and a high serum leptin concentration detected in some obese subjects were related to leptin resistance.…”

Section: Introductionmentioning

confidence: 99%

Dietary Patterns and Its Associations with Adipokines (Adiponectin and Leptin) among Adults: A Narrative Review

Zakarai¹,

Shahril²

2017

JSM

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“…For this, every item was multiplied by its corresponding loading in factor analysis. After that, the weighted mean was divided by the sum over the loadings which is named the factor score [26]. Every participant received a factor score for each identified pattern.…”

Section: Discussionmentioning

confidence: 99%

The association of dietary patterns with endocannabinoids levels in overweight and obese women

et al. 2020

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Background: Higher levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG), the main arachidonic acidderived endocannabinoids, are frequently reported in overweight and obese individuals. Recently, endocannabinoids have become a research interest in obesity area regarding their role in food intake. The relationship between dietary patterns and endocannabinoids is poorly understood; therefore, this study evaluated the association of the dietary patterns with AEA and 2-AG levels in overweight and obese women. Methods: In this cross sectional study, 183 overweight and obese females from Tabriz, Iran who aged between 19 and 50 years old and with mean BMI = 32.44 ± 3.79 kg/m 2 were interviewed. The AEA and 2-AG levels were measured, and the dietary patterns were assessed using food frequency questionnaire. To extract the dietary patterns, factor analysis was applied. The association between AEA and 2-AG levels and dietary patterns was analyzed by linear regression. Results: Three major dietary patterns including "Western", "healthy", and "traditional" were extracted. After adjusting for age, physical activity, BMI, waist circumference, and fat mass, higher levels of AEA and 2-AG were observed in participants who were in the highest quintile of the Western pattern (P < 0.05). Also, in both unadjusted and adjusted models, significantly lower levels of AEA and 2-AG were detected in the women of the highest quintile of the healthy pattern (P < 0.01). Moreover, there was no significant association between "traditional" pattern and AEA and 2-AG levels in both unadjusted and adjusted models (P > 0.05). Conclusion: In regard with the lower levels of endocannabinoids in healthy dietary pattern, adherence to healthy pattern might have promising results in regulating endocannabinoids levels.

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Association Between Dietary Patterns and Serum Leptin-to-Adiponectin Ratio in Apparently Healthy Adults

Abstract: Our findings indicate an inverse association between a Western dietary pattern and serum adiponectin levels but not for serum leptin or L/A ratio.

Cited by 14 publications

References 39 publications

Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors

Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors

Dietary Patterns and Its Associations with Adipokines (Adiponectin and Leptin) among Adults: A Narrative Review

The association of dietary patterns with endocannabinoids levels in overweight and obese women

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