Association between dietary inflammatory index and upper aerodigestive tract cancer risk: A systematic review and dose-response meta-analysis

Zhu, Jiahao; Ling, Yuxiao; Mi, Shuai; Chen, Hanzhu; Fan, Jiaqi; Cai, Shengguan; Fan, Chunhong; Shen, Qing; Li, Yingjun

doi:10.1016/j.oraloncology.2020.104587

Cited by 11 publications

(11 citation statements)

References 54 publications

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“…and Zhu et al. conducted two systematic reviews and dose–response meta-analyses on DII and upper aerodigestive tract cancer (UADT) ( 23 , 24 ). Considering that oral cancer was a major subtype of UADT, our meta-analysis was, to some extent, comparable to the two prior meta-analyses.…”

Section: Discussionmentioning

confidence: 99%

“…and Zhu et al. discovered that the pooled ORs of UADT cancer risk for the highest DII versus the lowest DII were 2.27 (1.89, 2.73) and 2.07 (1.82, 2.35), respectively ( 23 , 24 ). The corresponding OR in our study was 2.35 (1.88, 2.94), which seemed to be similar to the ORs of the two prior studies.…”

Section: Discussionmentioning

confidence: 99%

“…However, the strength of the correlation varies among studies. In addition, although two systematic reviews and meta-analyses have been published in 2019 for DII and upper aerodigestive tract cancers, oral cancer as a subtype was not independently analyzed due to insufficient relevant studies ( 23 , 24 ). Therefore, we aimed to comprehensively assess the dose–response relationship between DII and oral cancer risk based on a systematic review and meta-analysis updated to March 2022.…”

Section: Introductionmentioning

confidence: 99%

“…Hua et al and Zhu et al discovered that the pooled ORs of UADT cancer risk for the highest DII versus the lowest DII were 2.27 (1.89, 2.73) and 2.07 (1.82, 2.35), respectively(23,24). The corresponding OR in…”

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Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis

Luo

Zhu

et al. 2022

Front. Oncol.

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BackgroundDietary inflammatory index (DII) has been suggested to be associated with oral cancer risk. However, a quantitative comprehensive assessment of the dose–response relationship has not been reported. We performed a meta-analysis to clarify the risk of oral cancer with DII.MethodsWe searched PubMed, Embase, Cochrane Library, and Web of Science databases for relevant articles published up to 1 March 2022. Fixed- or random-effects models were utilized to estimate the pooled odds ratio (OR) of oral cancer with DII, as appropriate. Restricted cubic splines were used to model the dose–response relationship.ResultsWe included five case–control studies involving 1,278 cases and 5,137 controls in the meta-analysis. Risk of oral cancer was increased by 135% with the highest versus lowest DII level [OR: 2.35, 95% confidence interval (CI): 1.88–2.94], and 79% with higher versus lower DII level (OR: 1.79, 95% CI: 1.49–2.15). We found no evidence of a nonlinear dose–response association of DII with oral cancer (pnon-linearity = 0.752), and the risk was increased by 17% (OR: 1.17, 95% CI: 1.05–1.30) with 1 unit increment in DII score.ConclusionThis meta-analysis suggested that a higher DII score was associated with increased risk of oral cancer. Therefore, reducing pro-inflammatory components and promoting anti-inflammatory components of diet may be effective in the prevention of oral cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis

Luo

Zhu

et al. 2022

Front. Oncol.

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“…In this research, DII was considered as an index that effectively represents dietary inflammatory status, based on several previous studies that have verified by the significant association of DII with inflammatory markers (47) . This index presents an alternative assessment tool for inflammation, as opposed to the laboratory-based techniques which are obtained through invasive methods and economically prohibitive (48) .…”

Section: Discussionmentioning

confidence: 99%

Modified Mediterranean diet v. traditional Iranian diet: efficacy of dietary interventions on dietary inflammatory index score, fatigue severity and disability in multiple sclerosis patients

et al. 2021

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Background Current evidence suggests that adherence to the Mediterranean Diet (MeD) can reduce inflammation in chronic diseases; however, studies pertaining to Relapsing-Remitting Multiple Sclerosis (RRMS) are limited. Therefore, the aim of this study was to investigate the potential of the modiﬁed MeD (mMeD) in improving Dietary Inflammatory Index (DII) scores, disability, and fatigue severity, compared to Traditional Iranian Diet (TID), in RRMS patients. Methods After initial screening (n=261), 180 RRMS patients were randomized to receive mMeD or TID (as control) for six months. DII score, Expanded Disability Status Scale (EDSS) and 21-item Modified Fatigue Impact Scale (MFIS) were evaluated at baseline and trial cessation. Multivariate analysis of covariance was conducted and adjusted for age, gender, body weight, body mass index, education level, supplement use, family history and duration of MS. Results Of the 180 patients enrolled, 147 participants were included in the ﬁnal analysis (n of mMeD=68; n of TID=79). Self-reported adherence was good (˜81%). Dietary intakes of 45 food parameters were assessed through the food frequency questionnaire. The mMeD significantly reduced DII scores after six months (2.38±0.21 to −1.87±0.86, P<0.001), but TID did not elicit any changes (2.21±0.44 to 2.14±1.01, P=0.771). Additionally, MFIS total score decreased significantly (72.4±17.2 to 63.9±14.2, P<0.001), whereas there was no considerable improvement for EDSS in the mMeD group. Conclusion Adherence to mMeD, for six months, improved dietary inflammatory status and fatigue severity in RRMS patients, however, the traditional Iranian diet did not positively impact dietary inflammation and MFIS score.

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Dietary acid load and risk of head and neck and oral cavity cancers: An epidemiologic study

Ronco

Martínez‐López

Calderón

et al. 2022

Oral Science International

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Aim Metabolic acidosis subsequent to a high dietary acid load (DAL) leads to inflammation and cell transformation, which are common features of cancer development. Because the epidemiologic evidence associating DAL and cancer risk is still limited, we sought to explore the potential role of DAL as a risk factor for head and neck and oral cavity tumors. Methods A case–control study was performed on 1126 men (563 cases and 563 age frequency and residence matched controls), drawn from the major public hospitals in Montevideo, Uruguay. Participants were interviewed through a multi‐topic questionnaire, including a food frequency questionnaire. Food‐derived nutrients were calculated from available databases. DAL was calculated based on validated measures including potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. Odds ratios (OR) were estimated by logistic regression, adjusting for potential confounders. Results We found significant and direct associations between dietary acid load and risk of head and neck and oral cavity cancers (OR = 2.10 and OR = 1.95 for highest PRAL and NEAP, respectively). In addition, stratified analyses by subsites displayed the highest estimates for pharyngeal cancer (OR = 2.40 and OR = 2.28 for highest PRAL and NEAP, respectively). No association was found for oral cavity cancers. Conclusions An acidogenic diet may increase the risk of head and neck cancers. Our findings align well with our previous studies focused on other anatomic sites. Studies conducted on food groups and nutritional patterns align with our results. Further studies are needed to confirm these findings.

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Association between dietary inflammatory index and upper aerodigestive tract cancer risk: A systematic review and dose-response meta-analysis

Cited by 11 publications

References 54 publications

Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis

Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis

Modified Mediterranean diet v. traditional Iranian diet: efficacy of dietary interventions on dietary inflammatory index score, fatigue severity and disability in multiple sclerosis patients

Dietary acid load and risk of head and neck and oral cavity cancers: An epidemiologic study

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