Association between dietary essential amino acids intake and metabolic biomarkers: influence of obesity among Chinese children and adolescents

Yu, Lianlong; Li, Yanmo; Zhang, Qian; Zhu, Lichao; Ding, Ning; Zhang, Bingyin; Zhang, Junli; Liang, Wenjie; Li, Suyun; Zhang, Jian

doi:10.1007/s00726-021-02970-4

Cited by 9 publications

(12 citation statements)

References 37 publications

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“…Furthermore, some EAAs have been demonstrated to stimulate glucose uptake in rodents [28][29][30] during OGTT. Therefore, EAA supplementation has been utilized as a potential nutritional treatment for various muscle atrophy conditions, including aging [31], obesity [32], and osteoporosis [33]. According to the above-mentioned results, it is suggested that EAAs may alleviate muscle atrophy induced by DEX via enhancement of muscle protein synthesis and glucose metabolism.…”

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confidence: 99%

Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice

et al. 2022

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Dexamethasone (DEX) induces dysregulation of protein turnover, leading to muscle atrophy and impairment of glucose metabolism. Positive protein balance, i.e., rate of protein synthesis exceeding rate of protein degradation, can be induced by dietary essential amino acids (EAAs). In this study, we investigated the roles of an EAA-enriched diet in the regulation of muscle proteostasis and its impact on glucose metabolism in the DEX-induced muscle atrophy model. Mice were fed normal chow or EAA-enriched chow and were given daily injections of DEX over 10 days. We determined muscle mass and functions using treadmill running and ladder climbing exercises, protein kinetics using the D2O labeling method, molecular signaling using immunoblot analysis, and glucose metabolism using a U-13C6 glucose tracer during oral glucose tolerance test (OGTT). The EAA-enriched diet increased muscle mass, strength, and myofibrillar protein synthesis rate, concurrent with improved glucose metabolism (i.e., reduced plasma insulin concentrations and increased insulin sensitivity) during the OGTT. The U-13C6 glucose tracing revealed that the EAA-enriched diet increased glucose uptake and subsequent glycolytic flux. In sum, our results demonstrate a vital role for the EAA-enriched diet in alleviating the DEX-induced muscle atrophy through stimulation of myofibrillar proteins synthesis, which was associated with improved glucose metabolism.

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confidence: 99%

Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice

et al. 2022

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“…Previous research has primarily focused on dietary protein or essential amino acids. [16][17][18][19][20][21] Due to its crucial role in metabolism and neural development, serine is considered a conditionally essential amino acid. 22 Individuals with low serine intake had significantly higher odds ratio (OR) of cognitive impairment compared to those with moderate or high intake, 23 which is consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Dietary serine intake is associated with cognitive function among US adults

Chen,

Fang,

Cai

et al. 2024

Food Funct.

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“…According to a study, the physiological functions of glutamic acid were reported as a potential therapeutic target for appetite regulation, body weight control, or obesity, as well as a biomarker for visceral obesity (30). In children and adolescents, leucine dietary intake was protective against obesity (31), yet in adults, the assessment of leucine intake distinctly showed a positive OR for general obesity, but not for central obesity, which was different from our research (32). On the other hand, in a case-control study, individuals with metabolic syndrome, diabetes, and obesity had lower circulating serine and proline pro les compared to healthy people with normal weight (33).…”

Section: Discussionmentioning

confidence: 99%

The relationship between amino acid intake patterns and both general and central obesity

Alijani,

Ahmadi,

Mohammadpour

et al. 2024

Preprint

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Background: Obesity is a threat to public health. Dietary protein and certain amino acids (AAs) have been associated with obesity; however, the association of AAs patterns with excess body weight has not been considered, yet. We aimed to examine the relationship between patterns of AA intake and obesity. Methods: This cross-sectional study was conducted on 3197 individuals aged 35 to 70 years. Sociodemographic, medical, physical activity, and anthropometric data were collected. Energy and AAs intake were obtained by food frequency questionnaire (FFQ). Factor analysis was utilized to determine the AA patterns. Using multiple logistic regression analysis, the odds ratio (OR) of obesity was calculated among individuals categorized into tertiles of the AAs patterns. Results: In this study, three AA patterns were identified. The aromatic pattern consists of phenylalanine, tryptophan, proline, glutamic acid, cysteine, serine, and leucine. Five essential AAs plus tyrosine, aspartic acid, arginine, and glycine were the components of the mixed pattern, and finally, the alanine pattern with high loadings for alanine and histidine was the third one. After adjusting for confounders, individuals in the highest tertile (T3) of the aromatic pattern had lower odds of developing central obesity compared to those in the lowest tertile (T1) (OR=0.72, 95% CI: 0.58-0.89; p=0.003), whereas this association was not observed in the alanine pattern. On the contrary, general obesity showed a positive association in T3 of the alanine pattern in comparison with T1 (OR=1.65, 95% CI: 1.02-2.67; p=0.039). Mixed pattern was not associated with any of the obesity types. Conclusions: The aromatic pattern intake may have an inverse association with central obesity, and following the alanine pattern my contribute to higher odds of developing general obesity. However, the elaborate relationship between AAs and adiposity warrants further investigation.

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Association between dietary essential amino acids intake and metabolic biomarkers: influence of obesity among Chinese children and adolescents

Cited by 9 publications

References 37 publications

Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice

Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice

Dietary serine intake is associated with cognitive function among US adults

The relationship between amino acid intake patterns and both general and central obesity

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