Association between diet quality indexes and the risk of short telomeres in an elderly population of the SUN project

Ojeda‐Rodríguez, Ana; Zazpe, Itzíar; Alonso‐Pedrero, Lucia; Zalba, Guillermo; Guillén-Grima, Francisco; Martínez‐González, Miguel Ángel; Martí, Amelia

doi:10.1016/j.clnu.2019.11.003

Cited by 36 publications

(34 citation statements)

References 69 publications

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“…Taking into account the gender and lifestyle differences and also all the possible socio-demographic, anthropometric, and clinical covariates, the authors conclude that a high adherence to MD is associated with a significant lower risk of shorter telomeres. Moreover, it is important to note that analogue results were shown in subjects following other diet regimens, but these data were found significant only for some and not all indexes [121].…”

Section: Predisposing/protective Genotypes Main Human Diseases and Tmentioning

confidence: 91%

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

et al. 2020

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The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the existence of predisposing or protective human genotypes due to allelic diversities and the impact of the MD on disease risk. A part of the review is dedicated to the nutrigenomic effects of the main cooking methods used in the MD and also to a comparative analysis of the nutrigenomic properties of the MD and other diet regimens and non-MD-related aliments. Taking all the data into account, the traditional MD emerges as a diet with a high antioxidant and nutrigenomic modulation power, which is an example of the “Environment-Livings-Environment” relationship and an excellent patchwork of interconnected biological actions working toward human health.

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Section: Predisposing/protective Genotypes Main Human Diseases and Tmentioning

confidence: 91%

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

et al. 2020

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“…To our knowledge, no previous study has evaluated the effect of overall diet quality on TL in children with abdominal obesity. In adults, a few cross‐sectional studies focusing on dietary indices and TL are available, but have yielded controversial findings 19‐24 . Higher adherence to a quality diet, measured by five different indices, was associated with lower risk of shorter TL in an elderly Spanish population 24 .…”

Section: Discussionmentioning

confidence: 99%

“…In adults, a few cross‐sectional studies focusing on dietary indices and TL are available, but have yielded controversial findings 19‐24 . Higher adherence to a quality diet, measured by five different indices, was associated with lower risk of shorter TL in an elderly Spanish population 24 . However, an association between diet quality and TL was only found in women in two large US cohort studies 19,20 .…”

Section: Discussionmentioning

confidence: 99%

“…These studies assessed isolated nutrients and food groups excluding a possible synergic effect among them. However, the use of dietary indices to evaluate the possible effect of overall diet on TL is a more holistic and informative approach 19‐24 . In this way, a higher adherence to a quality diet as measured by diet quality indices was associated with a lower risk of short telomeres in elderly subjects 24 and women 19,20 …”

Section: Introductionmentioning

confidence: 99%

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Associations of telomere length with two dietary quality indices after a lifestyle intervention in children with abdominal obesity: a randomized controlled trial

et al. 2020

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Background: Dietary factors seem to influence telomere length. Moreover, associations between changes in adiposity indices and telomere length (TL) have been found in intervention studies. Objective: We evaluated changes in two diet quality indices and their association with TL in children with abdominal obesity in a 12-month lifestyle intervention. Methods: Eighty-seven participants (7-16 years old) were assigned to the intervention (moderate hypocaloric Mediterranean diet) or usual care group (standard paediatric recommendations) for a 2-month intensive phase and a subsequent 10-month follow-up. Diet quality was assessed using the Diet Quality Index for Adolescents (DQI-A) and the Healthy Lifestyle Diet Index (HLD-I). TL was measured by monochrome multiplex real-time quantitative PCR. The intra-class correlation coefficient for TL was 0.793 (95% CI 0.707, 0.857). Results: After a 12-month lifestyle intervention, a significant reduction in BMI-SDS (−0.57 and −0.49 for the intervention and usual care groups, respectively) and fat mass was observed in all subjects without differences between groups. Changes in DQI-A (+12.36% vs +5.53%, P = .005) and HLD-I (+4.43 vs +1.09, P < .001) were higher in the intervention subjects compared with usual care subjects after 2 months. Interestingly, we observed a positive change in TL between 2 and 12 months (P = .025), which was associated with higher scores on the DQI-A

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“…11 The Prime Diet Quality Score (PDQS), 12,13 a food-based diet quality metric, was developed as a response to the need to characterize human diets in a standard way, considering the principles of simplicity, comprehensiveness, and associations with health outcomes. The PDQS, using primary data from a comprehensive, semi-quantitative food frequency questionnaire (FFQ), was previously found to predict coronary heart disease, gestational diabetes, hypertension in pregnancy, salivary telomere length, [12][13][14] and all-cause mortality (S. Gicevic, E. Tahirovic, S. Bromage, and W. Willet, unpublished data, June 2020). It was also associated with a lower prevalence of individual and cluster cardiovascular risk factors (ie, obesity, diabetes, hypertension, and dyslipidemia) among elderly people with metabolic syndrome 15 and with better pregnancy outcomes in low-income country setting.…”

Section: Iet Is the Leading Risk Factor For Morbiditymentioning

confidence: 99%

Development of a Diet Quality Screener for Global Use: Evaluation in a Sample of US Women

Gicevic

Mou

Bromage

et al. 2021

Journal of the Academy of Nutrition and Dietetics

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Association between diet quality indexes and the risk of short telomeres in an elderly population of the SUN project

Cited by 36 publications

References 69 publications

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

Associations of telomere length with two dietary quality indices after a lifestyle intervention in children with abdominal obesity: a randomized controlled trial

Development of a Diet Quality Screener for Global Use: Evaluation in a Sample of US Women

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