Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

Sartori, Michelle; Conti, Filipe Fernandes; Dias, Danielle da Silva; Santos, Fernando dos; Machi, Jacqueline Freire; Palomino, Zaira; Casarini, Dulce Elena; Rodrigues, Bruno; Angelis, Kátia De; Irigoyen, Maria‐Claudia

doi:10.3389/fphys.2017.00572

Cited by 13 publications

(11 citation statements)

References 52 publications

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“…The increase in left ventricular mass associated with increasing adiposity reflects increases in both left ventricular wall thickness and left ventricular internal dimension. Previously, we showed that ob/ob mice present diastolic dysfunction when compared to the wild type animals (Sartori et al, 2017). Indeed, in the present study, ob/ob animals presented an impairment on LVIDd, IVRT, and MPI, characterizing a diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 98%

“…The cardiovascular complications of diabetes mellitus include coronary heart disease (CHD), stroke, peripheral arterial disease, nephropathy, retinopathy, and possibly cardiomyopathy and neuropathy (Grundy et al, 1999). Recently, we showed that female adult ob/ob mice, a model of obesity and type 2 diabetes, present discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress (Sartori et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice

et al. 2019

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Objective: This study evaluated the effects of aerobic, resistance, and combined exercise training on cardiac function and autonomic modulation in female ob/ob mice.Methods: Four-week-old female wild type and obese (ob/ob) mice were divided into five groups (n = 8): control (WT), obese (OB) obese + aerobic training (OBA), obese + resistance training (OBR), and obese + combined training (OBC). The exercise training was performed on treadmill and/or ladder at 40–60% maximum test during 8 weeks. Cardiac function was measured using echo machine. Heart rate variability (HRV) was evaluated in the time and frequency domain.Results: OB group presented higher body weight gain (~600%), glycemia (~44%) and glucose intolerance (~150%), reduction of cardiac vagal modulation, evidenced by a lower RMMSD (~56%), total power and high frequency band, and a higher isovolumic relaxation time (IVRT) (~24%) in relation to the WT group. Aerobic and combined training led to a lower IVRT (OBA: ~14%; OBC: ~14%) and myocardial global index (OBA: ~37%; OBC: ~44%). The OBA group presented an increased in vagal indexes of HRV than the other ob/ob groups. A negative correlation was observed between the delta of aerobic exercise capacity and MPI (r = 0.45; p = 0.002) and exercise capacity and body weight gain (r = 0.39; p = 0.002).Conclusion: Only the obese females underwent to aerobic exercise training showed improvement in cardiac function and HRV. Moreover, the aerobic exercise capacity as well as a greater responsivity to aerobic exercise training is intimately associated with these improvements, reinforcing the importance of aerobic exercise training to this population.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice

et al. 2019

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“…In a randomized sample of the PREDIMED study, Mediterranean dietary intervention was shown to reduce biomarkers of heart failure and inflammation [122]. Others have described the association between inflammatory markers and diastolic dysfunction in pre-clinical models, the bidirectional relationship of heart failure and inflammation, and suggested that control of inflammation is a critical consideration for the management of heart failure [125,126]. Importantly, Levitan et al, demonstrated that adherence to either the Dietary Approaches to Stop Hypertension (DASH) and Mediterranean dietary patterns reduced heart failure mortality [127].…”

Section: High-fat Diet and The Heartmentioning

confidence: 99%

Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms—A Narrative Review

et al. 2020

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The majority of the epidemiological evidence over the past few decades has linked high intake of fats, especially saturated fats, to increased risk of diabetes and cardiovascular disease. However, findings of some recent studies (e.g., the PURE study) have contested this association. High saturated fat diets (HFD) have been widely used in rodent research to study the mechanism of insulin resistance and metabolic syndrome. Two separate but somewhat overlapping models—the diacylglycerol (DAG) model and the ceramide model—have emerged to explain the development of insulin resistance. Studies have shown that lipid deposition in tissues such as muscle and liver inhibit insulin signaling via the toxic molecules DAG and ceramide. DAGs activate protein kinase C that inhibit insulin-PI3K-Akt signaling by phosphorylating serine residues on insulin receptor substrate (IRS). Ceramides are sphingolipids with variable acyl group chain length and activate protein phosphatase 2A that dephosphorylates Akt to block insulin signaling. In adipose tissue, obesity leads to infiltration of macrophages that secrete pro-inflammatory cytokines that inhibit insulin signaling by phosphorylating serine residues of IRS proteins. For cardiovascular disease, studies in humans in the 1950s and 1960s linked high saturated fat intake with atherosclerosis and coronary artery disease. More recently, trials involving Mediterranean diet (e.g., PREDIMED study) have indicated that healthy monounsaturated fats are more effective in preventing cardiovascular mortality and coronary artery disease than are low-fat, low-cholesterol diets. Antioxidant and anti-inflammatory effects of Mediterranean diets are potential mediators of these benefits.

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“…The influence of inflammatory factors on LVDD is a relatively new topic in the literature. The results of the first studies to appear on this subject in the last few months have focused on both animal and human populations [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…Another experimental study assessed the function of the autonomic and circulatory system, inflammatory markers, and oxidation in two groups of female mice (a group of wild mice [n = 14] and a group of mice with leptin deficiency [n = 14]) [21]. The examined animals underwent an assessment of metabolic parameters, evaluation of heart function using echocardiography, including systolic dysfunction and LVDD (isovolumetric time and the E/A ratio) [22], as well as testing of autonomic and endocrine system indicators and inflammatory and oxidative stress markers.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study

Kloch¹,

Stolarz‐Skrzypek²,

Olszanecka³

et al. 2019

Kardiol Pol

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Background: Heart failure affects patients with normal left ventricular systolic function (heart failure with preserved ejection fraction [HFPEF]) and those with reduced ejection fraction (HFREF). The treatment of HFPEF remains an unresolved issue. Aim: We sought to determinate the relationship between inflammatory markers and left ventricular diastolic dysfunction (LVDD) in a family-based population study. Methods: A total of 303 participants from the general population (55% women, median age 49 years and 45% men, median age 40 years) underwent echocardiography and measurement of serum inflammatory markers: C-reactive protein (CRP), myeloperoxidase (MPO), and interleukin 6 (IL-6). Results: Serum IL-6 concentration correlated with peak transmitral late diastolic velocity (A) and pulmonary vein systolic-to-diastolic velocity (S/D) ratio (p < 0.01). Moreover, a significant correlation between IL-6 concentration and E/A ratio and early diastolic peak velocities of the mitral annulus displacement (E') was observed. The association of IL-6 concentration and peak transmitral early diastolic velocities (E) and the E/E' ratio (p < 0.05) was noted in men. In addition, the CRP concentration was shown to have an effect on E/A ratio in women (p < 0.05). A significant correlation between the CRP concentration and S/D ratio was observed both in women (p < 0.01) and men (p < 0.05). No significant correlation was found between the level of MPO and LVDD parameters. Additionally, only one predictive model was identified; E' was found to be dependent on IL-6, age, and heart rate in men (p < 0.001, R 2 = 0.611). Conclusions: The above results suggest that inflammation may lead to the onset of LVDD, probably via vascular endothelial dysfunction.

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Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

Cited by 13 publications

References 52 publications

Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice

Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice

Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms—A Narrative Review

Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study

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