Association between diabetes mellitus and gastroesophageal reflux disease: A meta-analysis

Sun, Xiaomeng; Tan, Jiacheng; Zhu, Ying; Lin, Lin

doi:10.3748/wjg.v21.i10.3085

Cited by 67 publications

(65 citation statements)

References 49 publications

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“…In other research, upper GI endoscopy on DM patients who complained of gut symptoms revealed erosive esophagitis in 18% of the DM patients, which was a higher percentage than that seen in persons without DM [7]. A recent meta-analysis also reported a correlation between DM and GERD [21]; however, in the present study, the occurrence rate of GERD of 32.6% in the T2DM group and 35.9% in the control group indicated no significant correlation between the presence of diabetes and GERD. Typical GERD symptoms showed a prevalence of 58.8% in the T2DM group and 59.2% in the control group, again indicating no correlation.…”

Section: Discussionmentioning

confidence: 97%

Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus

Ha¹,

Lee

Lee³

et al. 2016

Diabetes Metab J

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BackgroundGastrointestinal symptoms are common in patients with type 2 diabetes mellitus (T2DM). The prevalence of gastroesophageal reflux disease (GERD) in Korea appears to be increasing. Some studies have shown that T2DM is a risk factor for symptomatic GERD. However, this possibility is still debated, and the pathogenesis of GERD in T2DM is not yet fully understood. The aim of this study was to analyze the prevalence and risk factors (including autonomic neuropathy) of GERD in patients with T2DM.MethodsThis cross-sectional case-control study enrolled T2DM patients (n=258) and healthy controls (n=184). All participants underwent physical examinations and laboratory tests. We evaluated medical records and long-term diabetes complications, including peripheral and autonomic neuropathy in patients with T2DM. Esophagogastroduodenoscopy was performed in all patients. The Los Angeles (LA) classification was used to grade GERD. GERD was defined as LA grade A (or higher) or minimal change with GERD symptoms. GERD symptoms were examined using a frequency scale. Data were expressed as mean±standard error. Independent t-tests or chi-square tests were used to make comparisons between groups.ResultsThe prevalence of GERD (32.6% vs. 35.9%, P=0.266) and GERD symptoms (58.8% vs. 59.2%, P=0.503) was not significantly different between T2DM patients and controls. We found no significant differences between T2DM patients with GERD and T2DM patients without GERD with respect to diabetic complications, including autonomic neuropathy, peripheral neuropathy, duration of DM, and glucose control.ConclusionThe prevalence of GERD in patients with T2DM showed no difference from that of controls. GERD was also not associated with peripheral and cardiovascular autonomic neuropathy, age, or duration of DM in patients with T2DM.

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Section: Discussionmentioning

confidence: 97%

Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus

Ha¹,

Lee

Lee³

et al. 2016

Diabetes Metab J

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“…GERD is associated with DM, which indicates that DM likely also affects the LES and the EGJ. Motor dysfunctions of the UES and LES in DM have indeed been demonstrated .…”

Section: Diabetes‐induced Remodeling In the Esophagusmentioning

confidence: 99%

“…The symptoms may be severe and may substantially decrease quality of life. Furthermore, gastroesophageal reflux disease (GERD) is associated with DM . A prospective questionnaire study demonstrated that GERD symptoms are 25% more common in type 2 DM patients than in the general population .…”

Section: Introductionmentioning

confidence: 99%

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Diabetes‐induced mechanophysiological changes in the esophagus

Zhao

Gregersen

2016

Annals of the New York Academy of Sciences

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Esophageal disorders are common in diabetes mellitus (DM) patients. DM induces mechanostructural remodeling in the esophagus of humans and animal models. The remodeling is related to esophageal sensorimotor abnormalities and to symptoms frequently encountered by DM patients. For example, gastroesophageal reflux disease (GERD) is a common disorder associated with DM. This review addresses diabetic remodeling of esophageal properties and function in light of the Esophagiome, a scientifically based modeling effort to describe the physiological dynamics of the normal, intact esophagus built upon interdisciplinary approaches with applications for esophageal disease. Unraveling the structural, biomechanical, and sensory remodeling of the esophagus in DM must be based on a multidisciplinary approach that can bridge the knowledge from a variety of scientific disciplines. The first focus of this review is DM-induced morphodynamic and biomechanical remodeling in the esophagus. Second, we review the sensorimotor dysfunction in DM and how it relates to esophageal remodeling. Finally, we discuss the clinical consequences of DM-induced esophageal remodeling, especially in relation to GERD. The ultimate aim is to increase the understanding of DM-induced remodeling of esophageal structure and sensorimotor function in order to assist clinicians to better understand the esophageal disorders induced by DM and to develop better treatments for those patients.

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“…Dysmotility problems are mainly related to motor dysfunctions and cause severe problems, such as delayed gastric emptying [5,6]. Esophageal motor function is very much affected by chronic diabetes, and delayed esophageal transit is a frequent problem that affects the quality of life in diabetic patients [7,8] as well as patients with GERD [9]. Some studies researching the relationship between diabetes and GERD had results contrary to expectations [10].…”

Section: Introductionmentioning

confidence: 99%

Esophageal Epithelial Resistance and Lower Esophageal Sphincter Muscle Contraction Increase in a Chronic Diabetic Rabbit Model

et al. 2016

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The acid-pepsin model in the diabetic rabbit esophageal tissue had less injury compared with the control. The diabetic rabbit LES muscle had higher contractility, possibly because of the activation of the Rho-Rhokinase pathway. Our results show that in a chronic diabetic rabbit model the esophagus resists reflux by activating mechanisms of mucosal defense and increasing the contractility of the LES.

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Association between diabetes mellitus and gastroesophageal reflux disease: A meta-analysis

Abstract: This meta-analysis suggests that patients with DM are at greater risk of GERD than those who do not have DM.

Cited by 67 publications

References 49 publications

Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus

Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus

Diabetes‐induced mechanophysiological changes in the esophagus

Esophageal Epithelial Resistance and Lower Esophageal Sphincter Muscle Contraction Increase in a Chronic Diabetic Rabbit Model

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