Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 Diabetes

et al. 2022

Preprint

Background Triglyceride glucose (TyG) index has been considered a new biomarker for diagnosis of angiocardiopathy and insulin resistance. However, the association of TyG index with subclinical left ventricular (LV) systolic dysfunction still lacks a comprehensive exploration. The study was carried out to examine this relationship in the asymptomatic with type 2 diabetes mellitus (T2DM). Methods 150 T2DM cases with preserved LV ejection fraction (LVEF ≥ 50%) from June 2021 to December 2021 were enrolled in this study. The subclinical LV function was evaluated through global longitudinal strain (GLS), with the pre-defined GLS < 18% as the cutoff for subclinical LV systolic dysfunction. The TyG index calculation was achieved according to ln (fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2), which was then stratified into 4 quartiles (TyG-Q). Results The analyses of baseline characteristics in the four TyG-Q (Q1 (TyG ≤ 8.89) n = 38, Q2 (8.89 < TyG ≤ 9.44) n = 37, Q3 (9.44 < TyG ≤ 9.83) n = 38, and Q4 (TyG > 9.83) n = 37) were conducted. A negative correlation of TyG index with GLS (r=-0.307, P < 0.001) was revealed according to correlation analysis. After the gender and age adjusted in multi-model logistic regression analysis, the higher TyG index (OR 6.86; 95% CI 2.44 to 19.30; P < 0.001, Q4 vs Q1) showed a significant association with GLS < 18%, which was still maintained after further adjustment for related clinical confounding factors (OR 5.15, 95%CI 1.13 to 23.39, p = 0.034, Q4 vs Q1). Receiver operator characteristic analysis indicated a diagnostic capacity of TyG index for GLS < 18% (area under curve: 0.678; P < 0.001). Conclusions Higher TyG index had a significant association with the subclinical LV systolic dysfunction in asymptomatic T2DM patients, with the potential to exert prognostic value for the progression of myocardial damage.

Section: Discussionsupporting

confidence: 66%

Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes

Chen

et al. 2022

Preprint

“…The TyG index, derived from FBG and TG, was proven to be a reliable and simple surrogate for metabolic syndrome and IR (22). Mounting evidence has proved the crucial value of TyG index in predicting diabetic complications in patients with T2DM (23)(24)(25). Study by Liu et al showed a significant association between TyG index and the risk of diabetic nephropathy in 682 adult patients (18).…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index for the detection of subclinical heart failure with preserved ejection fraction in patients with type 2 diabetes

Front. Cardiovasc. Med.

Zhang

et al. 2023

ObjectivesThe triglyceride-glucose (TyG) index has been identified as a reliable and simple surrogate of insulin resistance. In this study, we sought to determine the association between TyG index and cardiac function among asymptomatic individuals with type 2 diabetes (T2DM) without history of any cardiovascular disease.Materials and methodsThe cross-sectional study enrolled 180 T2DM patients without cardiac symptoms. Heart failure with preserved ejection fraction (HFpEF) was defined as Heart Failure Association (HFA)-PEFF score ≥ 5 points.ResultsA total of 38 (21.1%) diabetic patients were identified with HFpEF. Compared with the low-TyG group (TyG index <9.47), patients in high-TyG group (TyG index ≥9.47) showed increased risk of metabolic syndrome and diastolic dysfunction (p < 0.05 for each). Furthermore, after adjustment of confounding variables, the TyG index showed positive correlation with risk factors of metabolic syndrome (including BMI, waist circumference, blood pressure, HbA1c, TG, TC, non-HDL-C, and fasting blood glucose, p < 0.05 for each) and parameters of diastolic dysfunction (E/e’ ratio, p < 0.0001) in patients with T2DM. Moreover, Receiver Operating Characteristic curve analysis showed that the TyG index could be better to predict the risk of suspected HFpEF than other indicators (AUC: 0.706, 95% CI: 0.612–0.801). According, on multiple regression analysis, TyG index was independently correlated with the incidence of HFpEF (odds ratio: 0.786, p = 0.0019), indicating that TyG index could be a reliable biomarker to predict the risk of HFpEF.ConclusionThe TyG index showed a positive correlation with the risk of subclinical HFpEF in patients with T2DM, providing a new marker to predict and treat HFpEF in diabetes.

“…The TyG index, derived from FBG and TG, was proven to be a reliable and simple surrogate for metabolic syndrome and IR [18]. Mounting evidence has proved the crucial value of TyG index in predicting diabetic complications in patients with T2DM [19][20][21]. Study by Liu et al showed a signi cant association between TyG index and the risk of diabetic nephropathy in 682 adult patients with T2DM [22].…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index for the detection of subclinical heart failure with preserved ejection fraction in patients with type 2 diabetes

Zhang

et al. 2022

Preprint

Objectives The triglyceride-glucose (TyG) index has been identified as a reliable and simple surrogate of insulin resistance. In this study, we sought to determine the association between TyG index and cardiac function among asymptomatic individuals with type 2 diabetes (T2DM) without history of any cardiovascular disease. Materials and Methods The cross-sectional study enrolled 180 T2DM patients without cardiac symptoms. Heart failure with preserved ejection fraction (HFpEF) was defined as Heart Failure Association (HFA)-PEFF score ≥ 5 points. Results A total of 38 (21.1%) diabetic patients were identified with HFpEF. Compared with the low-TyG group (TyG index < 9.47), patients in high-TyG group (TyG index ≥ 9.47) showed increased risk of metabolic syndrome and diastolic dysfunction (P < 0.05 for each). Furthermore, after adjustment of confounding variables, the TyG index showed positive correlation with risk factors of metabolic syndrome (including BMI, HbA1c, TG, TC, non-HDL-C, and fasting blood glucose, P < 0.05 for each) and parameters of diastolic odysfunction (E/e’ ratio, P < 0.0001) in patients with T2DM. Moreover, receive operating characteristic analysis showed that the TyG index could be better to predict the risk of suspected HFpEF than other indicators (AUC: 0.706, 95% CI: 0.612–0.801). According, on multiple regression analysis, TyG index was independently correlated with the incidence of HFpEF (odds ratio: 0.883, P = 0.0003), indicating that TyG index could be a reliable biomarker to predict the risk of HFpEF. Conclusions The TyG index showed a positive correlation with the risk of subclinical HFpEF in patients with T2DM, providing a new marker to predict and treat HFpEF in diabetes.