Association between diabetes and vestibular dysfunction: an integrative review

Toledo, Roberta Carneiro de; Formiga, Cibelle Kayenne Martins Roberto; Ayres, Flávio Monteiro

doi:10.1590/1982-0216/20202214719

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…We observed that VNG manifestations indicating central VD were more prevalent than peripheral type (67.86 vs. 29.28%). Central VD manifestations included altered oculomotor movements (saccadic, tracking, and optokinetic), bilateral caloric hyporesponsiveness, and downbeating positional nystagmus without torsional component [Biurrun et al, 1991; Gawron et al, 2002;de Toledo et al, 2020]. Manifestations of peripheral VD included dizziness (28.57%), UW (15%), vertical-torsional positional nystagmus (2.5%), and unilateral deficiency type of post head-shaking nystagmus (5%).…”

Section: Discussionmentioning

confidence: 99%

Vestibular Function in Children with Type 1 Diabetes: Videonystagmography Testing

2021

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Background: Vestibular system is critical for maintaining balance and learning complex tasks. This study aimed to determine the frequencies, types, and predictors of vestibular dysfunctions (VDs) in children with type 1 diabetes (T1D) using videonystagmography (VNG). Patients and Methods: This study included 65 patients (children with T1D = 40; controls = 25). The patients underwent VNG. Results: Patients (boys = 15; girls = 25) had a mean age of 14.05 ± 1.82 years and duration of illness of 6.30 ± 2.84 years. The majority had frequent attacks of diabetic ketoacidosis (DKA) (65%) and hypoglycemia (40%). Dizziness was reported in 20%. VNG abnormalities were reported in 70% (n = 28), of them 71.43 and 28.57% had central and peripheral VDs, respectively. Dizziness was associated with peripheral VD. Compared to patients without VDs, those with VDs were older and had earlier age at onset and longer duration of diabetes (>5 years), higher levels of HbA1c (>7%), higher frequencies of DKA and hypoglycemic attacks, comorbid medical conditions, and diabetic complications. Multiple logistic regression analysis showed that presence of VNG abnormalities (VDs) was independently correlated with diabetes duration >5 years (odds ratio [OR] = 4.52 [95% confidence interval [CI] = 3.55–7.04], p = 0.001), HbA1c% levels >7% (OR = 3.42 [95% CI = 2.84–5.75], p = 0.001), and presence of hypoglycemic attacks (OR = 4.65 [95% CI = 2.85–7.55]). Conclusions: -VDs are prevalent in children with T1D and correlated with the duration and severity of diabetes and the occurrence of hypoglycemic attacks. Therefore, optimizing glycemic control and prevention and treatment of diabetic complications and comorbidities are important. Multidisciplinary follow-ups are required for early detection and management of diabetic VDs.

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Section: Discussionmentioning

confidence: 99%

Vestibular Function in Children with Type 1 Diabetes: Videonystagmography Testing

2021

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“…The role of MDA in screening diabetic patients for determining their risk of developing cochleopathy that can lead to irreversible sensorineural hearing loss has been illustrated by studies (17). Poorly controlled/uncontrolled/chronic diabetic patients are more susceptible to develop vestibulopathy (18,19).…”

Section: Discussionmentioning

confidence: 99%

Use of malondialdehyde (MDA) as a screening tool for vestibulopathy inType2 diabetes mellitus

Sumathi¹,

Dilliraj²,

Sridevi³

et al. 2021

Biomedicine

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Introduction and Aim:Diabetes mellitus, especially type II DM is one among the most prevalent metabolic diseases in the global scale. One of the commonest complications of diabetes mellitus is vestibulopathy affecting the inner ear. Malondialdehyde (MDA) obtained from lipid peroxidation of poly unsaturated fatty acids (PUFA) is an important compound that generally serves as one of the key markers for oxidative stress. The aim of the study is to prove the significance of MDA in Vestibulopathy in Type-2 i.e.,non-insulin dependent diabetes mellitus. Methodology: A cross-sectional study of 100 diabetic patients of age group between 35 years and 50 years were tested for vestibular function by electronystagmography(Commonly used test to determine and evaluate vestibular system). Based on the biothermal caloric stimulation the Clausen butterfly chart was generated and thus the code is ascertained. Serum levels of Malon-di-aldehyde were assayed by TBARS method (Thiobarbituric acid Reactive substances). Results: The study proved, that there was a 4 times increased risk of developing vestibulopathy with increasing duration of diabetes. It also proved that there was an increased risk of developing vestibulopathy in diabetic patients, having MDA > 2?mol/L. Conclusion: Thereby the study confirmed the clinical significance of periodic screening of MDA levels, in diabetic patients, particularly those with uncontrolled/poor glycemic control & with longer duration of diabetes. Estimation of their serum MDAlevels and vestibular function by the electronystagmography test, is advised in order to prevent the occurrence of diabetic vestibulopathy at the earliest and also to prevent the worsening of any such, other complications associated with the disease.

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Diabetic Foot Considerations Related to Plantar Pressures and Shear

Martin

Davis

2023

Foot and Ankle Clinics

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Association between diabetes and vestibular dysfunction: an integrative review

Cited by 3 publications

References 23 publications

Vestibular Function in Children with Type 1 Diabetes: Videonystagmography Testing

Vestibular Function in Children with Type 1 Diabetes: Videonystagmography Testing

Use of malondialdehyde (MDA) as a screening tool for vestibulopathy inType2 diabetes mellitus

Diabetic Foot Considerations Related to Plantar Pressures and Shear

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