Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort

Kim, Hyunkyu; Jeong, Wonjeong; Kwon, Junhyun; Kim, Youseok; Park, Sohee; Jang, Sung In

doi:10.1038/s41598-021-02201-6

Cited by 11 publications

(9 citation statements)

References 36 publications

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“…Demographic factors include age, sex, ethnicity (whites / non-whites), Townsend index, education (college/university degree and above / others), smoking status (never or former/current smoker), and alcohol use (never or former/current drinker). In addition, health-related information including diabetes mellitus (no/yes), hypertension (no/yes), history of myocardial infarction (no/yes), and history of stroke (no/yes) at baseline were introduced as covariates based on previous studies (32)(33)(34)(35).…”

Section: Covariatesmentioning

confidence: 99%

Association between retinal arteriolar branching geometry and risk of Alzheimer’s disease

Chen,

Bulloch,

et al. 2023

Preprint

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Background Alzheimer’s disease (AD) is a progressive neurodegenerative disease with an increasing fatality rate and population burden. Previously, retinal vascular parameters have been linked to AD, suggesting assessment of retinal vascular parameters may offer a new target for screening patients at risk of AD. Aim To investigate the association between retinal arteriolar branching geometry and risk for Alzheimer’s disease. Design and Setting: Retrospective analysis of cohort study. Methods Participants of the UK Biobank with gradable fundoscopy images and free of AD at baseline were included for analyses. Retina-based Microvascular Health Assessment System (RMHAS) was applied to retinal images to segment arterioles and quantify retinal arteriolar branching parameters (angular asymmetry, AA, and branching coefficient, BC). Cox proportional hazards regression models investigated the associations between retinal arteriolar branching parameters as continuous and categorical variables in quantiles and incident AD. Results We included a total of 29,483 participants. 83(0.28%) participants developed AD during a median of 10.98 years. When modeled as continuous variables, angular asymmetry, and branching coefficient were significantly associated with Alzheimer’s disease (HR = 5.05, 95% CI = 1.82–14.1, P = 0.002; HR = 0.14, 95% CI = 0.02–0.75, P = 0.022, respectively). Such associations were also valid when BC and AA were analyzed as categorical variables (smallest quartile vs biggest three quartiles; HR = 2.97, 95% CI = 1.47–6.02, P = 0.002; HR = 0.43, 95% CI = 0.23–0.83; P = 0.012). Increased retinal arteriolar angular asymmetry and decreased branching coefficient conferred a long-term risk of AD. Conclusions This study found a significant association between retinal arteriolar branching geometry and the risk of AD, suggesting its potential value as a biomarker for AD.

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Section: Covariatesmentioning

confidence: 99%

Association between retinal arteriolar branching geometry and risk of Alzheimer’s disease

Chen,

Bulloch,

et al. 2023

Preprint

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“…Next, 2002-2004 was set as the washout period to ensure the exclusion of patients diagnosed before 2005. The 2002-2004 washout period was a stricter criterion because the NHIS database started in 2002 [24,25]. In addition, to ensure a 5-year survival period after cancer diagnosis, participants who were first diagnosed with gastric cancer in 2010-2013 were excluded.…”

Section: Data and Study Populationmentioning

confidence: 99%

Difference in medical service use among Korean gastric cancer survivors according to regional healthcare vulnerabilities: a cohort study

Jeong

Joo

Park

et al. 2022

Support Care Cancer

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Purpose This study investigated the relationship between medical service use and healthcare vulnerability, pre- and post-gastric cancer diagnosis. Differences between healthcare-vulnerable and healthcare-nonvulnerable regions identified inequities that require intervention. Methods This cohort study was done using the National Health Insurance claims data of patients diagnosed with gastric cancer between 2004 and 2013. The Position Value for Relative Comparison Index was used to determine whether the patients lived in a healthcare-vulnerable region. Medical service use was classified into annual outpatient treatment, hospitalization days, and emergency treatment. We used a generalized linear model to which the Poisson distribution was applied and compared regional differences in medical service use. Results A total of 1797 gastric cancer patients who had survived 5 years post-diagnosis were included in the study, of which 14.2% lived in healthcare-vulnerable regions. The patients in vulnerable regions surviving 5–7 years post-diagnosis had a higher number of outpatient visits than those in nonvulnerable regions. Furthermore, hospitalization days were lesser for patients in vulnerable regions who survived 6 years post-diagnosis than those in nonvulnerable regions; however, this number increased in the seventh year. Conclusions Our results suggest that gastric cancer survivors living in healthcare-vulnerable regions have a higher probability of increased medical service use 5 years post-diagnosis compared with patients in nonvulnerable regions, which may significantly increase healthcare disparities over time. Therefore, in the future, additional research is needed to elucidate the causes of the disparities in healthcare use and the results of the differences in health outcomes.

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“…Similarly, a study involving 92 participants showed that individuals diagnosed with hypertension had significantly lower cognitive abilities 21 . Additionally, a meta-analysis examining studies conducted with over one and a half million individuals found that the use of antihypertensive medication was identified as a protective factor against Alzheimer's disease 22 .…”

Section: Introductionmentioning

confidence: 99%

Insights from Turkey's big data: unraveling the preventability, pathogenesis, and risk management of Alzheimer's disease (AD)

Yiğit,

Ata,

Dinçer

et al. 2024

Sci Rep

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Extensive research into dementia has more recently honed in on several key areas. These areas include the advancement of techniques such as the accumulation of amyloid-β and tau proteins, the monitoring of cerebral hypometabolism rates etc. The primary objective of this study is to explore the intricate interplay between Alzheimer's disease (AD)—other dementias (D) and various chronic illnesses in terms of time, intensity, and connectivity. In this context, we retrospectively examined data of 149,786 individuals aged 65 and above who received diagnoses of AD and D in the year 2020. At first, logistic regression (LR) analysis has been made with “sex”, “age” and “foreigner” (citizenship status) independent variables for AD and D. The LR models shows that while “sex” and “age” variables have a small rate on the risk of developing AD/D, it is detected that being a foreigner increase the risk of AD and D as 69.8% and 88.5% respectively. Besides, the LR models have middle-level success prediction rate for both of the two dependent variables. Additionally, we used the parallel coordinates graphs method within the R Studio to visualize their relationships and connections. The findings of this investigation strongly suggest that AD/D don’t stand as isolated conditions, but rather stem from intricate interactions and progressive processes involving diverse chronic diseases over time. Notably, ailments including hypertension, coronary artery disease, diabetes, hyperlipidemia, and psychological disorders, contribute substantially to the emergence of both AD and D. This study highlights that the fight against AD/D can only be possible with next-generation prophylactic interventions that can predict and manage risks. Such an approach holds the potential to potentially lower AD and dementia to levels that are amenable to treatment.

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Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort

Cited by 11 publications

References 36 publications

Association between retinal arteriolar branching geometry and risk of Alzheimer’s disease

Association between retinal arteriolar branching geometry and risk of Alzheimer’s disease

Difference in medical service use among Korean gastric cancer survivors according to regional healthcare vulnerabilities: a cohort study

Insights from Turkey's big data: unraveling the preventability, pathogenesis, and risk management of Alzheimer's disease (AD)

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