Association Between Depression and Death in People With CKD: A Meta-analysis of Cohort Studies

Palmer, Suetonia C.; Vecchio, Mariacristina; Craig, Jonathan C.; Tonelli, Marcello; Johnson, David W.; Nicolucci, Antonio; Pellegrini, Fabio; Saglimbene, Valeria; Logroscino, Giancarlo; Hedayati, S. Susan; Strippoli, Giovanni F.M.

doi:10.1053/j.ajkd.2013.02.369

Cited by 148 publications

(119 citation statements)

References 69 publications

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“…Occurrence of DS has been deemed a cause for increased risk of death in similar populations. 33,34 However, no statistically significant difference in mortality rates was observed between groups. Zimmermann et al followed a similar cohort of 125 patients for 8 years, and demonstrated that mortality rate was associated with age, treatment modality (HD or peritoneal dialysis), and occurrence of DS; kidney transplantation was the main mortalitylowering factor.…”

mentioning

confidence: 81%

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Barros

Costa

Mottin

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To prospectively evaluate depressive symptoms, nutritional status, and quality of life (QoL) and search for possible associations in patients with end-stage renal disease undergoing hemodialysis. Methods: A cohort study of 104 adult patients with end-stage renal disease undergoing hemodialysis was conducted. Anthropometric, clinical, and biochemical variables were evaluated after a midweek hemodialysis session. The participants' body composition was assessed by direct segmental multifrequency bioimpedance analysis. The WHOQOL-Bref questionnaire was used to evaluate QoL. Participants were separated into two groups -depressive symptoms and no depressive symptoms -at inclusion and evaluated annually for 2 years thereafter using the Beck Depression Inventory. Survival analysis used the Kaplan-Meier method and Cox regression analysis for the goodness of fit of associated factors. All-cause mortality was the outcome of interest. Results: Participants' mean age was 55.3615.6 years, 60% were male, and the median time on hemodialysis was 17.5 (8.0-36.8) months. Thirty-two patients had depressive symptoms and a significantly lower QoL compared with the 72 patients in the no depressive symptoms group. The fitted outcome model showed that lean body mass had a protective effect against all-cause mortality (hazard ratio [HR] = 0.89; 95%CI 0.80-0.99; p = 0.038). Conclusion: Depressive symptoms were highly prevalent in the cohort, and correlated with the physical and psychological components of the QoL life questionnaire, as well as with C-reactive protein and phosphorus levels. Lean body mass was protective for the assessed outcome.

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mentioning

confidence: 81%

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Barros

Costa

Mottin

et al. 2016

Rev. Bras. Psiquiatr.

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“…42 Notably, the method of measuring depression (self-rating scale vs interview or physician assessment) did not appear to modify the association between depression and mortality. 43 Of greater clinical relevance are persistent symptoms of depression. One study in which depression was measured at 6-monthly intervals in 917 incident patients undergoing dialysis for 2 years found that persistent or recurrent depression was associated with cardiovascular mortality, whereas depression detected over 6 months previously or at baseline only was not associated with mortality.…”

Section: Consequences Of Depression and Anxiety On Treatment Outcomesmentioning

confidence: 99%

Anxiety and depression in patients with end-stage renal disease: impact and management challenges – a narrative review

Goh¹,

Griva²

2018

IJNRD

144

116

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Psychiatric disorders commonly co-exist with the diagnosis of chronic kidney disease (CKD). Research on depression and CKD has increased to a great extent. Multiple studies have demonstrated that depression is more prevalent in CKD and that end-stage renal disease is a robust risk factor for adverse outcomes such as hospitalization and mortality, yet these are often underdiagnosed or untreated. This review provides a selective overview on the prevalence rates of depression and anxiety in patients with CKD and across renal replacement therapies, the factors most consistently associated with symptoms of distress and their clinical implications. Finally, treatment and management strategies from relevant literature are appraised and discussed.

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“…The risk of increased cardiovascular mortality was less clear (RR 1.88, 0.84-4.19, p = 0.2) [110]. Randomised trials of interventions for depression in CKD have been limited by small sample size, short duration and surrogate outcomes to determine efficacy [110].…”

Section: Depressionmentioning

confidence: 99%

Cardiovascular Disease in Dialysis Patients

Jegatheesan¹,

Yang²,

Krishnasamy³

et al. 2018

Aspects in Dialysis

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Cardiovascular disease (CVD) is highly prevalent in the dialysis population, affecting up to 60% of cohorts. Cardiovascular mortality rates are reported to be ~14 per 100 patient-years, which are 10-to 20-fold greater than those of age-and gender-matched controls. CVD is the primary cause of death in up to 40% of dialysis patients in Australia, New Zealand and the United States. Dialysis patients endure a greater burden of both traditional risk factors for CVD and risk factors related to loss of kidney function that may account for the higher CVD morbidity and mortality. Many cardiology guidelines include chronic kidney disease (CKD) and end-stage kidney disease (ESKD) as coronary heart disease (CHD) risk equivalents. It is therefore important for clinicians to both recognise and optimise the cardiovascular health of patients receiving maintenance dialysis. This chapter will focus on risk factor modification, screening and prevention of CVD in dialysis patients.

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Association Between Depression and Death in People With CKD: A Meta-analysis of Cohort Studies

Cited by 148 publications

References 69 publications

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Anxiety and depression in patients with end-stage renal disease: impact and management challenges – a narrative review

Cardiovascular Disease in Dialysis Patients

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Association Between Depression and Death in People With CKD: A Meta-analysis of Cohort Studies

Cited by 148 publications

References 69 publications

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Anxiety and depression in patients with end-stage renal disease: impact and management challenges &ndash; a narrative review

Cardiovascular Disease in Dialysis Patients

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Anxiety and depression in patients with end-stage renal disease: impact and management challenges – a narrative review