Association between dental health and acute myocardial infarction.

Mattila, Kimmo; Nieminen, Markku S.; Valtonen, Ville; Rasi, Vesa; Kesäniemi, Y. Antero; Syrjälä, S.; Jungell, Peter; Isoluoma, Martti; Hietaniemi, Katariina L.; Jokinen, Mervi

doi:10.1136/bmj.298.6676.779

Cited by 873 publications

(690 citation statements)

References 22 publications

(3 reference statements)

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“…In the 1980s and 1990s, researchers began publishing evidence that periodontal disease was related to major CVD-related adverse events and mortality (DeStefano et al, 1993;Mattila et al, 1989). Eventually, other health conditions such as stroke, diabetes, preterm birth, and osteoporosis were also linked to periodontal disease (Offenbacher & Beck, 2014).…”

Section: Discussionmentioning

confidence: 99%

Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure

Dekker

Lennie

Moser

et al. 2016

Biological Research For Nursing

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Aims: To describe correlations and agreement between salivary and serum B-type natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 and determine which biomarkers predict worse functional class in patients with heart failure (HF). Methods: Serum and saliva were collected from 75 hospitalized patients with HF (57 + 12 years, 43% female, New York Heart Association [NYHA] Classes I [4%], II [43%], and III [53%]). Oral inflammation was rated as good, fair, or poor. Spearman's r and Bland-Altman were used to determine correlations and agreement of the salivary and serum forms of each biomarker. Logistic regressions were used to determine which biomarkers predicted worse NYHA functional class, controlling for depression, body mass index, smoking, and oral inflammation. Results: Median biomarker concentrations were as follows: BNP (serum 361 pg/ml, saliva 9 pg/ml), CRP (serum 13 ng/ml, saliva 25.6 ng/ml), IL-6 (serum 19.3 pg/ml, saliva 10.5 pg/ml), and IL-10 (serum 64.1 pg/ml, saliva 4.7 pg/ml). There was a moderate-to-strong correlation for serum-salivary CRP, weak correlation for serum-salivary IL-6, and no correlations for serum-salivary BNP and IL-10. The Bland-Altman test showed good salivaryserum agreement for all biomarkers, but as serum concentrations rose, salivary measures underestimated serum levels. Visible oral inflammation was the only predictor of worse NYHA class.

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Section: Discussionmentioning

confidence: 99%

Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure

Dekker

Lennie

Moser

et al. 2016

Biological Research For Nursing

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“…Skipping forward to more recent times, evidence from well-designed studies began to emerge in the late 1980's of possible linkages between chronic periodontal disease and other systemic diseases. 3,4 Since then there has been an exponential rise in the number of studies that have investigated links between periodontal disease and various diseases with the main areas of interest being: atherosclerotic cardiovascular disease, 5 diabetes, 6 and adverse pregnancy outcome. 7 Associations between periodontitis and many other diseases and conditions have also been reported including respiratory disease; chronic kidney disease; rheumatoid arthritis; cognitive impairment; obesity; metabolic syndrome; and cancer.…”

Section: Basis For a Possible Relationship -Historical And Currentmentioning

confidence: 99%

Periodontitis and systemic disease

Winning

Linden

2015

BDJ Team

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“…There is considerable evidence that the clinical impact of periodontal disease extends beyond the oral cavity (2). Strong associations have been found between periodontitis and a number of systemic conditions, including cardiovascular disease (3,4), preterm delivery and low-birth-weight babies (5), diabetes mellitus (6)(7)(8), and rheumatoid arthritis (9)(10)(11).…”

mentioning

confidence: 99%

Dysbiosis and Alterations in Predicted Functions of the Subgingival Microbiome in Chronic Periodontitis

Kirst

Alfant

et al. 2015

Appl Environ Microbiol

186

188

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Chronic periodontitis is an inflammatory disease of the periodontium affecting nearly 65 million adults in the United States. Changes in subgingival microbiota have long been associated with chronic periodontitis. Recent culture-independent molecular studies have revealed the immense richness and complexity of oral microbial communities. However, data sets across studies have not been directly compared, and whether the observed microbial variations are consistent across different studies is not known. Here, we used 16S rRNA sequencing to survey the subgingival microbiota in 25 subjects with chronic periodontal disease and 25 healthy controls and compared our data sets with those of three previously reported microbiome studies. Consistent with data from previous studies, our results demonstrate a significantly altered microbial community structure with decreased heterogeneity in periodontal disease. Comparison with data from three previously reported studies revealed that subgingival microbiota clustered by study. However, differences between periodontal health and disease were larger than the technical variations across studies. Using a prediction score and applying five different distance metrics, we observed two predominant clusters. One cluster was driven by Fusobacterium and Porphyromonas and was associated with clinically apparent periodontitis, and the second cluster was dominated by Rothia and Streptococcus in the majority of healthy sites. The predicted functional capabilities of the periodontitis microbiome were significantly altered. Genes involved in bacterial motility, energy metabolism, and lipopolysaccharide biosynthesis were overrepresented in periodontal disease, whereas genes associated with transporters, the phosphotransferase system, transcription factors, amino acid biosynthesis, and glycolysis/gluconeogenesis were enriched in healthy controls. These results demonstrate significant alterations in microbial composition and function in periodontitis and suggest genes and metabolic pathways associated with periodontal disease. P eriodontal disease is a common disease affecting many adults in the United States. If left untreated, chronic periodontitis (CP) can lead to serious problems such as tooth loss. Indeed, periodontal disease is the number one cause of tooth loss in the United States, accounting for half of all tooth loss in U.S. adults (1). There is considerable evidence that the clinical impact of periodontal disease extends beyond the oral cavity (2). Strong associations have been found between periodontitis and a number of systemic conditions, including cardiovascular disease (3, 4), preterm delivery and low-birth-weight babies (5), diabetes mellitus (6-8), and rheumatoid arthritis (9-11).The activity of periodontal disease is determined by a complex interplay between the immune system and periodontal pathogens (12, 13). Alterations in subgingival microbiota have long been associated with the development and progression of periodontitis (14). In susceptible individuals, perturbations in...

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Association between dental health and acute myocardial infarction.

Cited by 873 publications

References 22 publications

Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure

Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure

Periodontitis and systemic disease

Dysbiosis and Alterations in Predicted Functions of the Subgingival Microbiome in Chronic Periodontitis

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