Association between Dementia and Clinical Outcome after COVID-19: A Nationwide Cohort Study with Propensity Score Matched Control in South Korea

Wang, Sheng‐Min; Park, See Hyun; Kim, Nak-Young; Kang, Dong Woo; Na, Hae-Ran; Um, Yoo Hyun; Han, Seunghoon; Lim, Hyun Kook

doi:10.30773/pi.2021.0064

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…191 Mortality among 223 patients with COVID-19 >50 years of age in South Korea who had underlying dementia was 33.6% compared with 20.2% among 223 propensity-matched patients with COVID-19 who did not have dementia (adjusted OR, 3.05 [95% CI, 1.80–5.30]); dementia was also associated with requiring a ventilator (24.1% versus 22.0% without dementia; P <0.001). 192 In a meta-analysis of 10 studies including 56 577 patients with COVID-19 with 10% prevalence of dementia, having dementia was associated with 1.80 times the adjusted odds of death (95% CI, 1.45–2.24). 193…”

Section: Brain Healthmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2023

Circulation

2,711

702

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BACKGROUND: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The American Heart Association, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2023 Statistical Update is the product of a full year’s worth of effort in 2022 by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. The American Heart Association strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional COVID-19 (coronavirus disease 2019) publications, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

show abstract

Section: Brain Healthmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2023

Circulation

2,711

702

View full text Add to dashboard Cite

show abstract

“…252 Mortality among 223 patients with COVID-19 >50 years of age in South Korea who had underlying dementia was 33.6% compared with 20.2% among 223 propensity-matched patients with COVID-19 who did not have dementia (aOR, 3.05 [95% CI, 1.80–5.30]); dementia was also associated with requiring a ventilator (24.1% versus 22.0% without dementia; P <0.001). 253 In a meta-analysis of 10 studies including 56 577 patients with COVID-19 with 10% prevalence of dementia, having dementia was associated with 1.80 times the adjusted odds of death (95% CI, 1.45–2.24). 254…”

Section: Brain Healthmentioning

confidence: 99%

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Martin,

Aday,

Almarzooq

et al. 2024

Circulation

View full text Add to dashboard Cite

BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2024 AHA Statistical Update is the product of a full year’s worth of effort in 2023 by dedicated volunteer clinicians and scientists, committed government professionals, and AHA staff members. The AHA strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional global data, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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“…10 Furthermore, the COVID-19 infection was associated with increased mortality in schizophrenia, 11 mood disorder, 12 and dementia. 13 The indirect effect of the COV-ID-19 pandemic, such as social isolation was reported in dementia patients from different countries. The most consistent finding was a higher rate of behavioral and neuropsychiatric symptoms due to social isolation in dementia patients.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, 1.6% (95% CI, 1.2–2.1) people older than 65 years were diagnosed with psychiatric disorders in the 14–90 days following the COVID-19 diagnosis [ 10 ]. Furthermore, the COVID-19 infection was associated with increased mortality in schizophrenia [ 11 ], mood disorder [ 12 ], and dementia [ 13 ]. The indirect effect of the COVID-19 pandemic, such as social isolation was reported in dementia patients from different countries.…”

Section: Discussionmentioning

confidence: 99%

The Impact of the COVID-19 Pandemic and Social Distancing on Cognition of Alzheimer’s Disease Patients

Joo

Hahn

Lee

2022

Psychiatry Investig

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Objective The risk of rapid cognitive decline in Alzheimer’s disease (AD) during the coronavirus disease 2019 (COVID-19) pandemic has been recognized. The purpose of this study was to investigate the cognitive decline in such patients during the COVID-19 pandemic by evaluating changes in their cognitive measure parameters before and after the pandemic.Methods This was a retrospective cohort study conducted in AD patients during their first visit and one-year regular follow-up for testing cognitive function at the Geriatric Psychiatry Clinic of Seoul St. Mary’s Hospital. Changes in the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Sum of Box for CDR (CDR-SB) scores were investigated. A time series analysis was performed to determine whether there was a significant difference in the MMSE, CDR, and CDR-SB scores of AD patients in pre- and post–COVID-19 periods.Results Overall, 130 AD patients aged 60 to 93 years were assessed. Their baseline mean MMSE score was 22.30 which had decreased to 21.08 at the one-year follow-up. Before November 2019, the average CDR differences for one year was 0.06, but after November 2019, it increased to 0.36 (p<0.001). Before November 2019, the average of the CDR-SB change value for one year was 1.69, but after November 2019, it increased to 3.00 (p<0.001). The difference in MMSE values for one year was not statistically significant. The time series analysis revealed a significant increase in the CDR and CDR-SB scores by approximately 0.47 (p=0.005) and 2.39 (p=0.002), before and after November 1, 2019, respectively.Conclusion This study revealed that the COVID-19 pandemic and social distancing worsen cognitive function in AD patients rapidly. Exposure to the COVID-19 pandemic and social distancing for at least seven months worsen cognitive decline significantly. Therefore, in order to minimize the adverse effects of the cognitive decline in these patients, the period of social distancing should be minimized.

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Association between Dementia and Clinical Outcome after COVID-19: A Nationwide Cohort Study with Propensity Score Matched Control in South Korea

Cited by 11 publications

References 27 publications

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

The Impact of the COVID-19 Pandemic and Social Distancing on Cognition of Alzheimer’s Disease Patients

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