Association between decreased serum albumin levels and depressive symptoms in patients with schizophrenia in a Chinese Han population: A pilot study

Chen, Shan; Xia, Hai Sen; Zhu, Feng; Yin, Guiqin; Qian, Zhiyuan; Jiang, Cai Xia; Gu, Xiao Chu; Xiong, Yin; Tang, Wen Jie; Zhang, Tian Hong; Wang, Ji Jun; Jia, Qiu Fang; Li, Hui

doi:10.1016/j.psychres.2018.10.012

Cited by 32 publications

(30 citation statements)

References 38 publications

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“…ALB is an endogenous antioxidant with radical scavenging properties that inhibits lipid peroxidation so as to directly scavenge certain radicals. In this study, whether in acute or remission stage, level of ALB in SCZ was lower than that of HC, and decreased after treatment, which was consistent with the previous study [29], indicating that ALB in patients with SCZ was constantly persistently consumed in acute and remission stage. In spite of the fact that albumin levels decreased in acute and remission stage as well as after treatment, the decline was modest, and the albumin levels of patients with SCZ in every stage were still in normal range.…”

Section: Discussionsupporting

confidence: 92%

Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

Wen

Wang

et al. 2020

Preprint

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Background: Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidant between schizophrenia patients and healthy controls. Methods: Peripheral UA, ALB and TBIL of 107 schizophrenic patients in acute stage and 101 in remission stage were measured respectively, so were 273 healthy controls. Results: The levels of UA ( P =0.020) and TBIL ( P <0.001) of schizophrenic patients in acute stage were higher than those of healthy controls, while the level of ALB ( P <0.001) was lower. Similar results were detected form schizophrenic patients in remission stage. Schizophrenic patients in acute stage were divided into antipsychotics-use subgroup (n=56) and antipsychotics-naïve/free subgroup (n=51). The level of UA ( P =0.001) in antipsychotics-use subgroup was higher than that in antipsychotics-naïve/free subgroup, while the level of TBIL ( P =0.002) was lower than that in antipsychotics-naïve/free subgroup. 77 schizophrenic patients in acute stage were followed up, and there was no significant difference in level of UA before and after treatment, but levels of ALB ( P <0.001) and TBIL ( P <0.001) decreased significantly after the treatment. Conclusion: This study demonstrated that the dysfunction of peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia. Keywords: Schizophrenia; Uric acid; Albumin; Total bilirubin

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Section: Discussionsupporting

confidence: 92%

Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

Wen

Wang

et al. 2020

Preprint

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“…ALB is an endogenous antioxidant with radical scavenging properties that inhibits lipid peroxidation by binding metal ions responsible for the generation of most of the reactive oxygenated radical species [4]. In this study, whether in acute or remission stage, level of ALB in SCZ was lower than that of HC, and decreased after treatment, which was consistent with the previous study [33], indicating that ALB in patients with SCZ was constantly persistently consumed in acute and remission stage.…”

Section: Discussionsupporting

confidence: 91%

“…In this study, it was noted that the level of TBIL in SCZ was higher than that of HC, both in the acute and remission stage, which was confirmed by another recent study [34]. The elevated serum bilirubin may be a result of the increasing fragility of the erythrocyte membrane under oxidative stress [33,36]. At the same time, the pro-oxidant effect of heme-oxygenase may outrun the antioxidant property of bilirubin [37].…”

Section: Discussionsupporting

confidence: 63%

Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

Wen

Wang

et al. 2020

Preprint

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Background: Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidants between schizophrenia patients and healthy controls. Methods: Peripheral UA, ALB, and TBIL of 107 schizophrenic patients in the acute stage and 101 in the remission stage were measured respectively, so were 273 healthy controls. Results: The levels of UA ( P =0.020) and TBIL ( P <0.001) of schizophrenic patients in acute stage were higher than those of healthy controls, while the level of ALB ( P <0.001) was lower. Similar results were detected form schizophrenic patients in the remission stage. Schizophrenic patients in acute stage were divided into antipsychotics-use subgroup (n=56) and antipsychotics-naïve/free subgroup (n=51). The level of UA ( P =0.001) in the antipsychotics-use subgroup was higher than that in the antipsychotics-naïve/free subgroup, while the level of TBIL ( P =0.002) was lower than that in antipsychotics-naïve/free subgroup. 77 schizophrenic patients in the acute stage were followed up, and there was no significant difference in the level of UA before and after treatment, but levels of ALB ( P <0.001) and TBIL ( P <0.001) decreased significantly after the treatment. Conclusion: This study demonstrated that the dysfunction of the peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia.

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“…This is interesting, as there is some evidence for the relationship between lower albumin levels and attempted suicide [30], which is an important risk group for completed suicide [2][3][4]. These findings, taken together with the well-replicated negative association between depressive symptoms and albumin [10,[12][13][14][15][16][17][18][19][20][21][22][23], raise the issue whether there may be an association between albumin and depressive symptoms among individuals with a recent suicide attempt. Therefore, we aimed in this study to investigate the association between more severe depressive symptoms an important risk factor for suicide [2,28,29] and serum albumin among patients with attempted suicide.…”

Section: Introductionmentioning

confidence: 96%

“…However, this association between symptoms of depression and low albumin seems to be a part of a dysregulation oxidative stress [8]. There is also evidence for the relationship between lower serum albumin levels and depressive symptoms among patients with schizophrenia [23]. However, there are also contradictory, non-significant findings, reported in younger individuals aged <45 years [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Inverse association between serum albumin and depressive symptoms among drug-free individuals with a recent suicide attempt

Ambrus

Westling

2019

Nordic Journal of Psychiatry

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Background and aim: Albumin is a protein with multifaceted functions in the human body. According to many studies, lower serum albumin may be associated with depression in various groups of psychiatric and non-psychiatric patients, as well as with attempted suicide. As more severe depressive symptoms have been identified as a reliable risk factor for suicide in patients with high suicide risk, it would be of interest to study whether, the inverse association between depressive symptoms and albumin may exist among patients with attempted suicide. Therefore, the aim of the study was to investigate the possible association between albumin and depressive symptoms among individuals who recently attempted suicide. Methods: One-hundred twenty-seven individuals with a recent suicide attempt were involved in the study between 1987 and 2001. Albumin was analyzed in serum. Patients were evaluated with the Comprehensive Psychopathological Rating Scale (CPRS) from which the Montgomery-Åsberg Depression Rating Scale (MADRS) and the item assessing Apparent sadness were derived. Results: Only among patients aged 45, serum albumin levels were significantly and negatively correlated with total scores of MADRS and the item Apparent sadness (all p values <.00625). Conclusions: Our findings indicate an inverse association between serum albumin and the severity of depressive symptoms in individuals who attempted suicide, older than 45 years. ARTICLE HISTORY

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Association between decreased serum albumin levels and depressive symptoms in patients with schizophrenia in a Chinese Han population: A pilot study

Cited by 32 publications

References 38 publications

Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

Inverse association between serum albumin and depressive symptoms among drug-free individuals with a recent suicide attempt

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