Association between Daily Niacin Intake and Glaucoma: National Health and Nutrition Examination Survey

Abstract

Background and Aims: To determine the relationship between dietary intake of niacin and glaucoma using the data from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES). Methods: Subjects aged 40 years and older who participated in the dietary intake interview and vision health questionnaire of NHANES were included in the study. Glaucoma diagnosis by self-report was utilized. Additionally, glaucoma diagnosis by fundus imaging and International Society Geographical and Epidemiological Ophthalmology (ISGEO) criteria was used in subjects with available qualified retinal imaging. Survey logistic regression analyses were used to examine the association between daily niacin consumption and glaucoma. Results: A total of 5768 participants were included in the study. There was a significant decrease in the crude odds of self-reported glaucoma in the third (OR 0.57, 95% Cl 0.43–0.76; p < 0.001) and fourth (OR 0.57, 95% Cl 0.37–0.90; p = 0.018) quartiles of daily niacin consumption, which equated to 21.01 to 28.22 mg/day and greater than 28.22 mg/day, respectively. A similar trend was found using fundus imaging of subjects with niacin intake in the third (OR 0.42, 95% Cl 0.25–0.72; p = 0.002) and fourth (OR 0.36, 95% Cl 0.20–0.67; p = 0.002) quartiles. After adjusting for covariates, the odds of glaucoma based on fundus imaging remained significantly lower for niacin intake in the third (OR 0.49, 95% Cl 0.28–0.87; p = 0.016) and fourth (OR 0.48, 95% Cl 0.26–0.89; p = 0.022) quartile levels. Using ISGEO criteria, there was no significant association between glaucoma and daily niacin consumption. Conclusions: Greater niacin intake may be associated with a lower chance of developing glaucoma.

Comparative Topic Modeling for Determinants of Divergent Report Results Applied to Macular Degeneration Studies

“…Research on the relationship between niacin or molybdenum and MD proves challenging to find. Meanwhile, niacin has been shown to have potentially adverse ocular effects ( [64], [65]) while still offering some promise for glaucoma prevention [66].…”

Aqueous Humor Cytokine Response in the Contralateral Eye after First-Eye Cataract Surgery in Patients with Primary Angle-Closure Glaucoma, High Myopia or Type 2 Diabetes Mellitus

“…Type 2 DM was diagnosed according to a reported reference definition [15]. PACG was diagnosed based on the criteria of the International Society for Geographical and Epidemiological Ophthalmology (ISGEO) [16]. Briefly, PACG diagnosis was defined by a primary anatomic narrow-angle (180°or more of iridotrabecular contact assessed by indentation gonioscopy and ultrasound biomicroscopy (SW-3200L, Suoer Electronic Technology Co., Ltd., Tianjin, China)), with glaucomatous optic neuropathy (a vertical cup/disc [C/D] ratio >0.7 and/or C/D asymmetry >0.2 and/or focal notching of the neuroretinal rim), and compatible visual field defects measured using the Octopus 900 perimeter (Haag-Streit Inc., Köniz, Switzerland).…”

The use of Nicotinamide and Nicotinamide riboside as an adjunct therapy in the treatment of glaucoma

“…34 Furthermore, a recent report evaluating the publicly available data from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES), showed that the odds of having glaucoma were lower when the consumption of vitamin B3 was higher. 35 This article attempts to analyze the current knowledge regarding the use of vitamin B3, more specifically NAM and NR, for the prevention and/or treatment of glaucoma. For this review, 49 articles, published between 2000 and 2022, containing the terms "glaucoma" and "nicotinamide" were identified in PubMED.…”

“…34 Furthermore, a recent report evaluating the publicly available data from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES), showed that the odds of having glaucoma were lower when the consumption of vitamin B3 was higher. 35…”