Association between cytokine genes polymorphisms and type 1 diabetes: a case-control study on Saudi population

Allam, Gamal; Talaat, Iman M.; Abuelsaad, Abdelaziz S. A.; Bakheit, Ali M.; Nemenqani, Dalal; Alsulaimani, Adnan Amin

doi:10.1080/08820139.2017.1416398

Cited by 13 publications

(9 citation statements)

References 60 publications

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“…For the TNFα polymorphism, the GG genotype and G allele seem to offer a minor protective effect towards type 1 diabetes, which is contradictory to the data presented by literature 18…”

Section: Discussioncontrasting

confidence: 97%

<p>The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes</p>

Szabo¹,

Ilieş²,

Aioanei³

et al. 2019

DMSO

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IntroductionType 1 diabetes (T1DM) is a chronic autoimmune or idiopathic condition, featuring complex and unique interactions between proteins and enzyme systems. The purpose of the present study is to investigate the role of AdipoQ +276G>T, TNF-α-308G>A, GSTT1/GSTM1 polymorphic variants in the development of T1DM.Materials and methodsThe study is designed as a cross-sectional study, involving 72 diabetic cases and 90 controls. Genotyping was carried out according to specific protocols for the above-mentioned polymorphic variants.ResultsThe G allele of AdipoQ was associated with the development of type 1 diabetes (OR 0.577, CI95% 0.336–0.802, p=0.001), similar to the GG and GA genotypes (OR 0.405, CI95% 0.156–0.654, p=0.001 and OR 0.623, CI95% 0.401–0.855, p=0.004). The G allele of TNF-α was marginally associated with the development of type 1 diabetes (OR 0.789, CI95% 0.579–0.956, p=0.005). The presence of the T1 genotype was a strong predictor for type 1 diabetes (OR 3.4, CI95% 1.433–6.243, p<0.001).ConclusionThe results of our study suggest that G alleles of AdipoQ and TNFα act as a protective factor in T1DM, while the T1 allele for GST could be considered a risk factor for the development of Type 1 diabetes in our study group.

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“…For the TNFα polymorphism, the GG genotype and G allele seem to offer a minor protective effect towards type 1 diabetes, which is contradictory to the data presented by literature 18…”

Section: Discussioncontrasting

confidence: 97%

<p>The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes</p>

Szabo¹,

Ilieş²,

Aioanei³

et al. 2019

DMSO

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“…Moreover, a higher frequency of the rs1800629A allele was found among Australian and United Kingdom T1D patients compared with healthy controls (Kaidonis et al., 2016). By contrast, a study of Saudi patients by Allam et al claimed that the TNF‐α −308A was a risk factor for T1D; however, the authors did not implement the Bonferroni correction test for multiple comparisons to adjust their results (Allam et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, toll‐like receptors (TLRs), a group of proteins fundamental in innate immune responses involved in the pathogenesis of various autoimmune diseases (Kawai & Akira, 2010; Lien & Zipris, 2009), also play a crucial role in T1D (Sun et al., 2014; Xie et al., 2018). Multiple research studies have investigated associations between single‐nucleotide polymorphisms (SNPs) and the susceptibility to developing T1D with variable outcomes (Allam et al., 2018; Hollegaard & Bidwell, 2006; Javor et al., 2010).…”

Section: Introductionmentioning

confidence: 99%

Association of single‐nucleotide polymorphisms in tumour necrosis factor and human leukocyte antigens genes with type 1 diabetes

Osman

Brema

AlQurashi

et al. 2021

Int J Immunogenetics

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Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive destruction of insulin‐producing pancreatic beta cells. This multifactorial disease has a strong genetic component associated with the human leukocyte antigens (HLA) and non‐HLA regions. In this study, we compared frequencies of HLA‐DRB1 alleles and single‐nucleotide polymorphisms (SNPs) associated the genes coding for: toll‐like receptors (TLRs), tumour necrosis factor (TNF), interleukin‐1 (IL‐1), interleukin‐1 receptor type 1 (IL‐1R1), interleukin‐1 receptor antagonist (IL‐1RN), interleukin‐2 (IL‐2) and interleukin‐12B (IL‐12B), between T1D patients and healthy controls. The aim was to identify frequency differences and linkage between these genetic markers in T1D patients and healthy controls. Twelve SNPs were investigated as follows: rs16944 (IL‐1B), rs1143634 (IL‐1B), rs1800587 (IL‐1A), rs2069762 (IL‐2), rs3212227 (IL‐12B), rs2234650 (IL‐1R1), rs315952 (IL‐1RN), rs3804099 (TLR2), rs4986790 (TLR4), rs4986791 (TLR4), rs1800629 (TNF) and rs361525 (TNF). TaqMan genotype assay method was used for SNPs genotyping. HLA‐DRB1* genes were typed by Sequence Specific Oligonucleotide Probe (SSOP). SPSS and SNPStats programs were used for the statistical analysis. Significant differences between T1D and control groups were found for the dominant model of rs361525 and rs1800629A:rs361525G genotypes for TNF. Increased frequencies of DRB1*03 and DRB1*04 and decreased frequencies of DRB1*07, DRB1*11 and DRB1*13 and DRB1*15 were observed in T1D patients compared with controls. However, the genotype, DRB1*07 with rs1800629A/G was associated with T1D. We have confirmed that DRB1*03 and DRB1*04 are associated with increased risk and DRB1*07, DRB1*11 and DRB1*13 and DRB1*15 with decreased risk of T1D. Also, the dominant model of rs361525A, and the rs1800629G:361525A genotype were associated with increased risk. The simultaneous presence of DRB1*07 and rs1800629A/G genotypes in 23 out of 27 DRB1*07 positive T1D patients implied that islet cell peptide processing may have been biased towards autoimmunity by upregulation of TNF associated intronic SNPs.

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“…Thus, the IFN-␥ response seems not to be essential for insulitis and diabetes development in NOD mice [19]. A case-control study on Saudi subjects investigated the association of single nucleotide polymorphisms (SNPs) within cytokine genes such as IFN-␥ and the development of type I diabetes [20].…”

Section: Discussionmentioning

confidence: 99%

Levels of cytokines and GADA in type I and II diabetic patients

Amin

Qadr

Hussein

et al. 2020

Primary Care Diabetes

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Association between cytokine genes polymorphisms and type 1 diabetes: a case-control study on Saudi population

Abstract: Our data concluded that IFN-γ +874T allele, TNF-α -308A allele, IL-1β -511T allele, and IL-4 -590T allele could be considered risk factors for T1D development in Saudi subjects.

Cited by 13 publications

References 60 publications

<p>The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes</p>

<p>The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes</p>

Association of single‐nucleotide polymorphisms in tumour necrosis factor and human leukocyte antigens genes with type 1 diabetes

Levels of cytokines and GADA in type I and II diabetic patients

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